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Aromatase Inhibitors in the Treatment of Unexplained Female Infertility

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Unexplained Infertility

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Abstract

When considering treatment options for couples with unexplained infertility the initial approach often involves intrauterine insemination (IUI) combined with ovulation induction. Aromatase inhibition is a newer method of ovulation induction that has been used and studied as an alternative to clomiphene citrate (CC) to treat patients with unexplained infertility. Letrozole has been studied for its use as an adjunct to assisted reproductive technologies in an attempt to minimize the dose of costly gonadotropins needed and to overcome the adverse peripheral effects of clomiphene on the endometrium. Use of letrozole may eventually supersede that of clomiphene if the results of ongoing multicenter trials provide definitive evidence that letrozole has similar efficacy to gonadotropins or CC with a favorable side-effect profile and reduced cost.

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Authors and Affiliations

  1. Mount Sinai Medical Center, Klingenstein Pavilion, KP9, 1176 5th Ave, KP-9, New York, NY 10129, USA

    Lucky H. Sekhon MD

  2. Department of Obstetrics, Gynecology, & Reproductive Medicine, Icahn School of Medicine at Mount Sinai, 1245 Park Avenue, Apt. 5D, 10128, New York, NY, USA

    Patricia Rekawek & Lawrence Grunfeld

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  1. Lucky H. Sekhon MD
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  2. Patricia Rekawek
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  3. Lawrence Grunfeld
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Correspondence to Lucky H. Sekhon MD .

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Editors and Affiliations

  1. Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medical College, New York, New York, USA

    Glenn L. Schattman

  2. Andrology and Human Reproduction Clinic Referral Center for Male Reproduction, ANDROFERT, Campinas, São Paulo, Brazil

    Sandro C. Esteves

  3. Andrology Center & Center for Reproductive Medicine, Lerner College of Medicine Case Western Reserve University, Cleveland, Ohio, USA

    Ashok Agarwal

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Sekhon, L., Rekawek, P., Grunfeld, L. (2015). Aromatase Inhibitors in the Treatment of Unexplained Female Infertility. In: Schattman, G., Esteves, S., Agarwal, A. (eds) Unexplained Infertility. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2140-9_26

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