Unexplained Infertility

Pathophysiology, Evaluation and Treatment

  • Glenn L. Schattman
  • Sandro C. Esteves
  • Ashok Agarwal

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Definitions and Epidemiology

  3. Pathophysiology: Male

    1. Front Matter
      Pages 27-27
    2. Damayanthi Durairajanayagam, Anil K. Rengan, Rakesh K. Sharma, Ashok Agarwal
      Pages 29-42
    3. Michelle van der Linde, Stefan S. du Plessis
      Pages 43-51
    4. Brent M. Hardin, Edward D. Kim
      Pages 53-56
    5. Ricardo Miyaoka, Sandro C. Esteves
      Pages 57-70
    6. Rajesh K. Naz, Walter K. H. Krause
      Pages 71-80
    7. Sejal B. Doshi, Rakesh K. Sharma, Ashok Agarwal
      Pages 81-89
    8. Sandro C. Esteves, Sidney Verza, Rakesh K. Sharma, Jaime Gosálvez, Ashok Agarwal
      Pages 91-119
    9. Pieter Johann Maartens, Yapo Guillaume Aboua, Stefan S. Plessis
      Pages 121-138
  4. Pathophysiology: Female

    1. Front Matter
      Pages 139-139
    2. Daniela Galliano, Antonio Pellicer
      Pages 141-147
    3. Fatma Ferda Verit
      Pages 149-159
    4. Fabiana Y. Nakano, Rogério de Barros Ferreira Leão, Sandro C. Esteves
      Pages 175-183
    5. Alfredo Guillén Antón, Juan Antonio García Velasco
      Pages 185-191
    6. Thalia R. Segal, Avner Hershlag
      Pages 193-202
    7. Paula Andrea de Albuquerque de Salles Navarro, Anderson Sanches de Melo, Rui Alberto Ferriani
      Pages 203-209
  5. Evaluation

    1. Front Matter
      Pages 211-211
    2. Richard P. Dickey
      Pages 213-221
    3. Marcello Cocuzza, Bruno Camargo Tiseo
      Pages 223-237
  6. Expectant, Medical and Surgical Treatment

    1. Front Matter
      Pages 239-239
    2. N. M. van den Boogaard, Fulco van der Veen, Ben Willem Mol
      Pages 241-243
    3. Christopher L. Starks, Edmund S. Sabanegh
      Pages 255-259
    4. Lucky H. Sekhon, Patricia Rekawek, Lawrence Grunfeld
      Pages 273-281
    5. Anupa Nandi, Roy Homburg
      Pages 283-289
  7. Assisted Reproductive Techniques and Future Perspectives

    1. Front Matter
      Pages 291-291
    2. Rogério de Barros Ferreira Leão, Sandro C. Esteves
      Pages 293-322
    3. Paolo Emanuele Levi Setti, Irene Zerbetto, Alberto Vaiarelli, Marcello Desgro, Pasquale Patrizio
      Pages 323-328
    4. Hassan Sallam, Fathy Ezzeldin, Nooman Sallam
      Pages 329-333
    5. Bhushan K. Gangrade, Zamip Patel, Sejal Dharia Patel
      Pages 335-346
    6. Avinash Maganty, Ranjith Ramasamy, Peter N. Schlegel
      Pages 347-354
  8. Back Matter
    Pages 355-358

About this book


Written and edited by leading, internationally recognized clinicians and scientists in reproductive medicine and related fields, this unique text is a practical and comprehensive review of the clinical and scientific significance of unexplained male and female infertility and its management. The book is divided into thematic sections to ensure the most useful presentation of topics, opening with definitions and epidemiology of unexplained infertility, including discussion of the WHO’s cutoff values for human semen characteristics and its ramifications. Sections covering male and female reproductive pathophysiology follow respectively, covering biological, genetic and environmental causative factors, with a subsequent section on evaluative techniques for male and female patients. Expectant, medical and surgical treatment strategies comprise the fifth section of the book, where active interventions and outcomes of each treatment modality are carefully considered. The final section discusses assisted reproductive techniques to manage unexplained infertility, such as intrauterine insemination and in vitro fertilization, as well as future perspectives. Thoughtful and enlightening, Unexplained Infertility: Pathophysiology, Evaluation and Treatment will be an invaluable resource for all clinicians and scientists working in the fields of reproductive medicine and infertility.


Assisted reproductive techniques Endometrial receptivity Expectant management Fertility Gonadotoxin Gonadotropin Hormonal manipulation therapy Idiopathic infertility Immunological infertility In vitro fertilization Male factor infertility Oxidative stress Unexplained infertility

Editors and affiliations

  • Glenn L. Schattman
    • 1
  • Sandro C. Esteves
    • 2
  • Ashok Agarwal
    • 3
  1. 1.Ronald O. Perelman and Claudia Cohen Center for Reproductive MedicineWeill Cornell Medical CollegeNew YorkUSA
  2. 2.Andrology and Human Reproduction Clinic Referral Center for Male ReproductionANDROFERTCampinasBrazil
  3. 3.Andrology Center & Center for Reproductive MedicineLerner College of Medicine Case Western Reserve UniversityClevelandUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2015
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4939-2139-3
  • Online ISBN 978-1-4939-2140-9
  • Buy this book on publisher's site
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