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Targeted Therapies for Colorectal Cancer

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Targeted Therapies for Solid Tumors

Part of the book series: Current Clinical Pathology ((CCPATH))

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Abstract

In the last decades, the standard chemotherapeutic approach for the metastatic colorectal cancer (mCRC) treatment was represented by a 5-FU-based regimen with the addition of either oxaliplatin or irinotecan. Recent discoveries in the molecular biology field led to the spread of so-called targeted agents whose mechanism of action is based on the binding with specific target molecules (cellular receptors or soluble proteins) responsible for the activation of many transduction pathways required for malignant cell growth and survival. Among these, the most important consist of monoclonal antibodies (mAbs) and the tyrosine kinase inhibitors (TKIs). As a consequence, the different mechanism of action of these new drugs involves a variability of improved outcomes achieved and tolerability profile. These new chemotherapy options will represent in the next future the milestone of a new biological era for the treatment of mCRC patients.

Antonio Russo and Antonio Galvano equally contributed to this work

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Authors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Via del Vespro, 127, 90127, Palermo, Italy

    Antonio Russo MD PhD, Antonio Galvano & Giuseppe Bronte

  2. Oncology Department, University Hospital of Antwerp, Wilrijkstraat 10, 2650, Edegem, Belgium

    Marc Peeters

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  1. Antonio Russo MD PhD
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  2. Antonio Galvano
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  3. Giuseppe Bronte
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  4. Marc Peeters
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Correspondence to Antonio Russo MD PhD .

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Editors and Affiliations

  1. Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy

    Antonio Russo

  2. Catalan Institute of Oncology, University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

    Rafael Rosell

  3. Oncology Department, Antwerp University Hospital, Edegem, Antwerpen, Belgium

    Christian Rolfo

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Russo, A., Galvano, A., Bronte, G., Peeters, M. (2015). Targeted Therapies for Colorectal Cancer. In: Russo, A., Rosell, R., Rolfo, C. (eds) Targeted Therapies for Solid Tumors. Current Clinical Pathology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-2047-1_13

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