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Surgical Pathology Reporting of Renal Cell Carcinomas

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Genitourinary Pathology

Abstract

Given the importance of accurate surgical pathology reporting for kidney tumors, those factors necessary for a complete report (beyond grade, stage, and tumor type, which are treated elsewhere) are addressed in this chapter, with a survey of the data that support their inclusion.

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References

  1. Amtrup F, Hansen JB, Thybo E. Prognosis in renal carcinoma evaluated from histological criteria. Scand J Urol Nephrol. 1974;8(3):198–202.

    Article  CAS  PubMed  Google Scholar 

  2. Isbarn H, Patard JJ, Lughezzani G, Rioux-Leclercq N, Crepel M, Cindolo L, et al. Limited prognostic value of tumor necrosis in patients with renal cell carcinoma. Urology. 2010;75(6):1378–84.

    Article  PubMed  Google Scholar 

  3. Minervini A, Di Cristofano C, Gacci M, Serni S, Menicagli M, Lanciotti M, et al. Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers. J Urol. 2008;180(4):1284–9.

    Article  PubMed  Google Scholar 

  4. Leibovich BC, Blute ML, Cheville JC, Lohse CM, Frank I, Kwon ED, et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: a stratification tool for prospective clinical trials. Cancer. 2003;97(7):1663–71.

    Article  PubMed  Google Scholar 

  5. Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol. 2002;168(6):2395–400.

    Article  PubMed  Google Scholar 

  6. Pichler M, Hutterer GC, Chromecki TF, Jesche J, Kampel-Kettner K, Rehak P, et al. Histologic tumor necrosis is an independent prognostic indicator for clear cell and papillary renal cell carcinoma. Am J Clin Pathol. 2012;137(2):283–9.

    Article  PubMed  Google Scholar 

  7. Sengupta S, Lohse CM, Leibovich BC, Frank I, Thompson RH, Webster WS, et al. Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness. Cancer. 2005;104(3):511–20.

    Article  PubMed  Google Scholar 

  8. Ficarra V, Martignoni G, Lohse C, Novara G, Pea M, Cavalleri S, et al. External validation of the mayo clinic stage, size, grade and necrosis (SSIGN) score to predict cancer specific survival using a European series of conventional renal cell carcinoma. J Urol. 2006;175(4):1235–9.

    Article  PubMed  Google Scholar 

  9. Delahunt B, McKenney JK, Lohse CM, Leibovich BC, Thompson RH, Boorjian SA, et al. A novel grading system for clear cell renal cell carcinoma incorporating tumor necrosis. Am J Surg Pathol. 2013;37(3):311–22.

    Article  PubMed  Google Scholar 

  10. Przybycin CG, Cronin AM, Darvishian F, Gopalan A, Al-Ahmadie HA, Fine SW, et al. Chromophobe renal cell carcinoma: a clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution. Am J Surg Pathol. 2011;35(7):962–70.

    Article  PubMed  Google Scholar 

  11. Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, et al. The international society of urological pathology (ISUP) grading system for renal cell carcinoma and other prognostic parameters. Am J Surg Pathol. 2013;37(10):1490–504.

    Article  PubMed  Google Scholar 

  12. de Peralta-Venturina M, Moch H, Amin M, Tamboli P, Hailemariam S, Mihatsch M, et al. Sarcomatoid differentiation in renal cell carcinoma: a study of 101 cases. Am J Surg Pathol. 2001;25(3):275–84.

    Article  CAS  PubMed  Google Scholar 

  13. Shuch B, Bratslavsky G, Shih J, Vourganti S, Finley D, Castor B, et al. Impact of pathological tumour characteristics in patients with sarcomatoid renal cell carcinoma. BJU Int. 2012;109(11):1600–6.

    Article  PubMed  Google Scholar 

  14. Ro JY, Ayala AG, Sella A, Samuels ML, Swanson DA. Sarcomatoid renal cell carcinoma: clinicopathologic. A study of 42 cases. Cancer. 1987;59(3):516–26.

    Article  CAS  PubMed  Google Scholar 

  15. Cheville JC, Lohse CM, Zincke H, Weaver AL, Leibovich BC, Frank I, et al. Sarcomatoid renal cell carcinoma: an examination of underlying histologic subtype and an analysis of associations with patient outcome. Am J Surg Pathol. 2004;28(4):435–41.

    Article  PubMed  Google Scholar 

  16. Golshayan AR, George S, Heng DY, Elson P, Wood LS, Mekhail TM, et al. Metastatic sarcomatoid renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. J Clin Oncol. 2009;27(2):235–41.

    Article  PubMed  Google Scholar 

  17. Gokden N, Nappi O, Swanson PE, Pfeifer JD, Vollmer RT, Wick MR, et al. Renal cell carcinoma with rhabdoid features. Am J Surg Pathol. 2000;24(10):1329–38.

    Article  CAS  PubMed  Google Scholar 

  18. Brcic I, Spajic B, Kruslin B. Chromophobe renal cell carcinoma with rhabdoid differentiation in an adult. Wien klin Wochenschr. 2012;124(11–12):419–21.

    Article  PubMed  Google Scholar 

  19. Cheng JX, Tretiakova M, Gong C, Mandal S, Krausz T, Taxy JB. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21(6):647–52.

    Article  CAS  PubMed  Google Scholar 

  20. Kuroda N, Tamura M, Hamaguchi N, Mikami S, Pan CC, Brunelli M, et al. Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features. Ann Diagn Pathol. 2011;15(6):462–6.

    Article  PubMed  Google Scholar 

  21. Kuroiwa K, Kinoshita Y, Shiratsuchi H, Oshiro Y, Tamiya S, Oda Y, et al. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm. Histopathology. 2002;41(6):538–48.

    Article  CAS  PubMed  Google Scholar 

  22. Shannon B, Stan Wisniewski Z, Bentel J, Cohen RJ. Adult rhabdoid renal cell carcinoma. Arch Pathol Lab Med. 2002;126(12):1506–10.

    PubMed  Google Scholar 

  23. Leroy X, Zini L, Buob D, Ballereau C, Villers A, Aubert S. Renal cell carcinoma with rhabdoid features: an aggressive neoplasm with overexpression of p53. Arch Pathol Lab Med. 2007;131(1):102–6.

    CAS  PubMed  Google Scholar 

  24. Przybycin CG, McKenney JK, Reynolds JP, Campbell S, Zhou M, Karafa MT, et al. Rhabdoid differentiation is associated with aggressive behavior in renal cell carcinoma: a clinicopathologic analysis of 76 cases with clinical follow-up. Am J Surg Pathol. 2014;38:1260–5.

    Google Scholar 

  25. Lau WK, Blute ML, Weaver AL, Torres VE, Zincke H. Matched comparison of radical nephrectomy vs nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney. Mayo Clin Proc. 2000;75(12):1236–42.

    Article  CAS  PubMed  Google Scholar 

  26. Ito K, Nakashima J, Hanawa Y, Oya M, Ohigashi T, Marumo K, et al. The prediction of renal function 6 years after unilateral nephrectomy using preoperative risk factors. J Urol. 2004;171(1):120–5.

    Article  PubMed  Google Scholar 

  27. Henriksen KJ, Meehan SM, Chang A. Non-neoplastic renal diseases are often unrecognized in adult tumor nephrectomy specimens: a review of 246 cases. Am J Surg Pathol. 2007;31(11):1703–8.

    Article  PubMed  Google Scholar 

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Correspondence to Christopher G. Przybycin MD .

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Przybycin, C., Wu, A., Kunju, L. (2015). Surgical Pathology Reporting of Renal Cell Carcinomas. In: Magi-Galluzzi, C., Przybycin, C. (eds) Genitourinary Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2044-0_25

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  • DOI: https://doi.org/10.1007/978-1-4939-2044-0_25

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2043-3

  • Online ISBN: 978-1-4939-2044-0

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