Skip to main content

Endoscopic Treatment of Obesity

  • Chapter
  • First Online:
Gastrointestinal Endoscopy

Abstract

Obesity affects a third of the adults in the USA. Current weight-loss therapies include lifestyle therapy, pharmacotherapy, and bariatric surgery. Bariatric surgery is the most effective therapy; however, only 1 % of the patients who qualify are actually treated with bariatric surgery. Moreover, a weight regain in 3–10 years after bariatric surgery occurs in a significant number of patients and has been difficult to treat. New endoscopic procedures and endoscopically placed devices are currently being studied for use in the treatment of obesity. These devices and procedures overcome many of the obstacles preventing patients from undergoing bariatric surgery and provide a safer mechanism for treating weight regain after Roux-en-Y gastric bypass (RYGB). With these new therapies, endoscopists are poised to fill an important gap in the treatment of obese patients. This chapter reviews the role of endoscopy for weight regain after RYGB and in primary bariatric therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

RYGB:

Roux-en-Y gastric bypass

BMI:

Body mass index

BPD:

Biliopancreatic diversion

GJ:

Gastrojejunostomy

EBT:

Endoscopic bariatric therapy

IGB:

Intragastric balloon

DJBL:

Duodenal jejunal bypass liner

References

  1. Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA. 2007 Nov 7;298(17):2028–37. PubMed PMID: 17986696.

    Article  CAS  PubMed  Google Scholar 

  2. Katzmarzyk PT, Reeder BA, Elliott S, Joffres MR, Pahwa P, Raine KD, et al. Body mass index and risk of cardiovascular disease, cancer and all-cause mortality. Can J Public Health. 2012;103(2):147–51. PubMed PMID: 22530540.

    Google Scholar 

  3. Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al Mamun A, Bonneux L, et al. Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann Intern Med. 2003;138(1):24–32. PubMed PMID: 12513041.

    Article  PubMed  Google Scholar 

  4. Moriarty JP, Branda ME, Olsen KD, Shah ND, Borah BJ, Wagie AE, et al. The effects of incremental costs of smoking and obesity on health care costs among adults: a 7-year longitudinal study. J Occup Environ Med. 2012;54(3):286–91. PubMed PMID: 22361992.

    Article  PubMed  Google Scholar 

  5. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA. 2014;311(8):806–14.

    Article  CAS  PubMed  Google Scholar 

  6. Sjöström L, Lindroos A-K, Peltonen M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683–93. PubMed PMID: 15616203.

    Article  PubMed  Google Scholar 

  7. Christou NV, Look D, Maclean LD. Weight gain after short- and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006 Nov;244(5):734–40. PubMed PMID: 17060766. Pubmed Central PMCID: 1856611.

    Article  PubMed Central  PubMed  Google Scholar 

  8. Reinhold RB. Critical analysis of long term weight loss following gastric bypass. Surg Gynecol Obstet. 1982;155(3):385–94. PubMed PMID: 7051382. Epub 1982/09/01.

    CAS  PubMed  Google Scholar 

  9. Biron S, Hould FS, Lebel S, Marceau S, Lescelleur O, Simard S, et al. Twenty years of biliopancreatic diversion: what is the goal of the surgery? Obes Surg. 2004;14(2):160–4. PubMed PMID: 15018742.

    Article  PubMed  Google Scholar 

  10. Magro DO, Geloneze B, Delfini R, Pareja BC, Callejas F, Pareja JC. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18(6):648–51. PubMed PMID: 18392907.

    Article  PubMed  Google Scholar 

  11. Hsu LK, Betancourt S, Sullivan SP. Eating disturbances before and after vertical banded gastroplasty: a pilot study. Int J Eat Disord. 1996;19(1):23–34. PubMed PMID: 8640199.

    Article  CAS  PubMed  Google Scholar 

  12. White MA, Kalarchian MA, Masheb RM, Marcus MD, Grilo CM. Loss of control over eating predicts outcomes in bariatric surgery patients: a prospective, 24-month follow-up study. J Clin Psychiatry. 2010;71(2):175–84. PubMed PMID: 19852902. Pubmed Central PMCID: 2831110.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Hsu LK, Benotti PN, Dwyer J, Roberts SB, Saltzman E, Shikora S, et al. Nonsurgical factors that influence the outcome of bariatric surgery: a review. Psychosom Med. 1998;60(3):338–46. PubMed PMID: 9625222.

    Article  CAS  PubMed  Google Scholar 

  14. Kalarchian M, Marcus M, Wilson G, Labouvie E, Brolin R, LaMarca L. Binge eating among gastric bypass patients at long-term follow-up. Obes Surg. 2002;12(2):270–5.

    Article  PubMed  Google Scholar 

  15. Kofman MD, Lent MR, Swencionis C. Maladaptive eating patterns, quality of life, and weight outcomes following gastric bypass: results of an Internet survey. Obesity. 2010;18(10):1938–43. PubMed PMID: 20168309.

    Article  PubMed  Google Scholar 

  16. Saunders R. “Grazing”: a high-risk behavior. Obes Surg. 2004;14(1):98–102. PubMed PMID: 14980042.

    Article  PubMed  Google Scholar 

  17. Abu Dayyeh BK, Lautz DB, Thompson CC. Gastrojejunal stoma diameter predicts weight regain after Roux-en-Y gastric bypass. Clin Gastroenterol Hepatol. 2011;9(3):228–33.

    Article  PubMed Central  PubMed  Google Scholar 

  18. Heneghan HM, Yimcharoen P, Brethauer SA, Kroh M, Chand B. Influence of pouch and stoma size on weight loss after gastric bypass. Surg Obes Relat Dis. 2012;8(4):408–15.

    Article  PubMed  Google Scholar 

  19. Miras AD, Jackson RN, Jackson SN, Goldstone AP, Olbers T, Hackenberg T, et al. Gastric bypass surgery for obesity decreases the reward value of a sweet-fat stimulus as assessed in a progressive ratio task. Am J Clin Nutr. 2012;96(3):467–73. PubMed PMID: 22836034.

    Article  CAS  PubMed  Google Scholar 

  20. Schultes B, Ernst B, Wilms B, Thurnheer M, Hallschmid M. Hedonic hunger is increased in severely obese patients and is reduced after gastric bypass surgery. Am J Clin Nutr. 2010;92(2):277–83. PubMed PMID: 20519559.

    Article  CAS  PubMed  Google Scholar 

  21. Ullrich J, Ernst B, Wilms B, Thurnheer M, Schultes B. Roux-en Y gastric bypass surgery reduces hedonic hunger and improves dietary habits in severely obese subjects. Obes Surg. 2013;23(1):50–5. PubMed PMID: 22941334.

    Article  PubMed  Google Scholar 

  22. Pepino MY, Bradley D, Eagon JC, Sullivan S, Abumrad NA, Klein S. Changes in taste perception and eating behavior after bariatric surgery-induced weight loss in women. Obesity. 2014;22(5):E13–E20. PubMed PMID: 24167016.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Pepino MY, Stein RI, Eagon JC, Klein S. Bariatric surgery-induced weight loss causes remission of food addiction in extreme obesity. Obesity. 2014;22(8):1792–8. PubMed PMID 24852693.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Freire RH, Borges MC, Alvarez-Leite JI, Correia MITD. Food quality, physical activity, and nutritional follow-up as determinant of weight regain after Roux-en-Y gastric bypass. Nutrition. 2012;28(1):53–8.

    Article  PubMed  Google Scholar 

  25. Livhits M, Mercado C, Yermilov I, Parikh JA, Dutson E, Mehran A, et al. Preoperative predictors of weight loss following bariatric surgery: systematic review. Obes Surg. 2012;22(1):70–89. PubMed PMID: 21833817.

    Article  PubMed  Google Scholar 

  26. Abu Dayyeh BK, Ryan MB, Thompson CC. 309 Ghrelin and gastric pouch parameters are associated with feeding behaviors after roux-en-y gastric bypass. Gastroenterology. 2013;144(Supplement 1):S–64.

    Google Scholar 

  27. Roberts K, Duffy A, Kaufman J, Burrell M, Dziura J, Bell R. Size matters: gastric pouch size correlates with weight loss after laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2007;21(8):1397–402.

    Article  CAS  PubMed  Google Scholar 

  28. Campos GM, Rabl C, Mulligan K, Posselt A, Rogers SJ, Westphalen AC, et al. Factors associated with weight loss after gastric bypass. Arch Surg. 2008;143(9):877–83 (discussion 84). PubMed PMID: 18794426. Pubmed Central PMCID: 2747804.

    Article  PubMed Central  PubMed  Google Scholar 

  29. Hallowell PT, Stellato TA, Yao DA, Robinson A, Schuster MM, Graf KN. Should bariatric revisional surgery be avoided secondary to increased morbidity and mortality? Am J Surg. 2009;197(3):391–6. PubMed PMID: 19245921.

    Article  PubMed  Google Scholar 

  30. Zingg U, McQuinn A, DiValentino D, Kinsey-Trotman S, Game P, Watson D. Revisional vs. primary Roux-en-Y gastric bypass-a case-matched analysis: less weight loss in revisions. Obes Surg. 2010;20(12):1627–32. PubMed PMID: 20577830.

    Article  PubMed  Google Scholar 

  31. Radtka JF, 3rd, Puleo FJ, Wang L, Cooney RN. Revisional bariatric surgery: who, what, where, and when? Surg Obes Relat Dis. 2010;6(6):635–42. PubMed PMID: 20702147.

    Google Scholar 

  32. Morales MP, Wheeler AA, Ramaswamy A, Scott JS, de la Torre RA. Laparoscopic revisional surgery after Roux-en-Y gastric bypass and sleeve gastrectomy. Surg Obes Relat Dis. 2010;6(5):485–90.

    Article  PubMed  Google Scholar 

  33. Thompson CC, Slattery J, Bundga ME, Lautz DB. Peroral endoscopic reduction of dilated gastrojejunal anastomosis after Roux-en-Y gastric bypass: a possible new option for patients with weight regain. Surg Endosc. 2006;20(11):1744–8.

    Article  CAS  PubMed  Google Scholar 

  34. Herron D, Birkett D, Thompson C, Bessler M, Swanström L. Gastric bypass pouch and stoma reduction using a transoral endoscopic anchor placement system: a feasibility study. Surg Endosc. 2008;22(4):1093–9.

    Article  PubMed  Google Scholar 

  35. Thompson CC, Chand B, Chen YK, Demarco DC, Miller L, Schweitzer M, et al. Endoscopic suturing for transoral outlet reduction increases weight loss after Roux-en-Y gastric bypass surgery. Gastroenterology. 2013;145(1):129–37 e3. PubMed PMID: 23567348.

    Article  PubMed  Google Scholar 

  36. Thompson CC, Jacobsen GR, Schroder GL, Horgan S. Stoma size critical to 12-month outcomes in endoscopic suturing for gastric bypass repair. Surg Obes Relat Dis. 2012;8(3):282–7.

    Article  PubMed  Google Scholar 

  37. Jirapinyo P, Slattery J, Ryan MB, Dayyeh BKA, Lautz DB, Thompson CC. Evaluation of an endoscopic suturing device for transoral outlet reduction in patients with weight regain following Roux-en-Y gastric bypass. Endoscopy. 2013 Jul;45(07):532–6. PubMed PMID: 101055S00321326638.

    Article  CAS  PubMed  Google Scholar 

  38. Kumar N, Thompson CC. Comparison of a superficial suturing device with a full-thickness suturing device for transoral outlet reduction (with videos). Gastrointest Endosc. 2014;79(6):984–9.

    Article  PubMed  Google Scholar 

  39. Mullady DK, Lautz DB, Thompson CC. Treatment of weight regain after gastric bypass surgery when using a new endoscopic platform: initial experience and early outcomes (with video). Gastrointest Endosc. 2009;70(3):440–4.

    Article  PubMed  Google Scholar 

  40. Ryou M, Mullady DK, Lautz DB, Thompson CC. Pilot study evaluating technical feasibility and early outcomes of second-generation endosurgical platform for treatment of weight regain after gastric bypass surgery. Surg Obes Relat Dis. 2009;5(4):450–4.

    Article  PubMed  Google Scholar 

  41. Horgan S, Jacobsen G, Weiss GD, Oldham JS Jr, Denk PM, Borao F, et al. Incisionless revision of post-Roux-en-Y bypass stomal and pouch dilation: multicenter registry results. Surg Obes Relat Dis. 2010;6(3):290–5.

    Article  PubMed  Google Scholar 

  42. Thompson CC, Jacobsen GR, Schroder GL, Horgan S. Stoma size critical to 12-month outcomes in endoscopic suturing for gastric bypass repair. Surg Obes Relat Dis. 2011. doi:10.1016/j.soard.2011.03.014. PubMed PMID: 21640665.

    Google Scholar 

  43. Mikami D, Needleman B, Narula V, Durant J, Melvin WS. Natural orifice surgery: initial US experience utilizing the StomaphyX device to reduce gastric pouches after Roux-en-Y gastric bypass. Surg Endosc. 2010;24(1):223–8. PubMed PMID: 19633885.

    Article  PubMed  Google Scholar 

  44. Leitman IM, Virk CS, Avgerinos DV, Patel R, Lavarias V, Surick B, et al. Early results of trans-oral endoscopic plication and revision of the gastric pouch and stoma following Roux-en-Y gastric bypass surgery. JSLS. 2010;14(2):217–20. PubMed PMID: 20932372. Pubmed Central PMCID: 3043571.

    Article  PubMed Central  PubMed  Google Scholar 

  45. Goyal V, Holover S, Garber S. Gastric pouch reduction using StomaphyX™ in post Roux-en-Y gastric bypass patients does not result in sustained weight loss: a retrospective analysis. Surg Endosc. 2013;27(9):3417–20.

    Article  PubMed  Google Scholar 

  46. Eid GM, McCloskey CA, Eagleton JK, Lee LB, Courcoulas AP. Stomaphyx vs a sham procedure for revisional surgery to reduce regained weight in roux-en-y gastric bypass patients: a randomized clinical trial. JAMA Surg. 2014;149(4):372–9.

    Article  PubMed  Google Scholar 

  47. Catalano MF, Rudic G, Anderson AJ, Chua TY. Weight gain after bariatric surgery as a result of a large gastric stoma: endotherapy with sodium morrhuate may prevent the need for surgical revision. Gastrointest Endosc. 2007;66(2):240–5. PubMed PMID: 17331511.

    Article  PubMed  Google Scholar 

  48. Spaulding L, Osler T, Patlak J. Long-term results of sclerotherapy for dilated gastrojejunostomy after gastric bypass. Surg Obes Relat Dis. 2007;3(6):623–6. PubMed PMID: 17936088.

    Article  PubMed  Google Scholar 

  49. Loewen M, Barba C. Endoscopic sclerotherapy for dilated gastrojejunostomy of failed gastric bypass. Surg Obes Relat Dis. 2008;4(4):539–42 (discussion 42–3). PubMed PMID: 18069073.

    Article  PubMed  Google Scholar 

  50. Madan AK, Martinez JM, Khan KA, Tichansky DS. Endoscopic sclerotherapy for dilated gastrojejunostomy after gastric bypass. J Laparoendoss Adv Surg Tech A. 2010;20(3):235–7. PubMed PMID: 20374012.

    Article  Google Scholar 

  51. Abu Dayyeh BK, , Jirapinyo P, , Weitzner Z, , Barker C, , Flicker MS, , Lautz DB, et al. Endoscopic sclerotherapy for the treatment of weight regain after Roux-en-Y gastric bypass: outcomes, complications, and predictors of response in 575 procedures. Gastrointest Endosc. 2012;76(2):275–82.

    Article  PubMed  Google Scholar 

  52. Spaulding L. Treatment of dilated gastrojejunostomy with sclerotherapy. Obes Surg. 2003;13(2):254–7.

    Article  PubMed  Google Scholar 

  53. Heylen AM, Jacobs A, Lybeer M, Prosst RL. The OTSC(R)-clip in revisional endoscopy against weight gain after bariatric gastric bypass surgery. Obes Surg. 2011;21(10):1629–33. PubMed PMID: 20814761.

    Article  PubMed  Google Scholar 

  54. Schauer PR, Kashyap SR, Wolski K, Brethauer SA, Kirwan JP, Pothier CE, et al. Bariatric surgery versus intensive medical therapy in obese patients with diabetes. N Engl J Med. 2012;366(17):1567–76.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  55. O’Brien PE, Dixon JB, Laurie C, Skinner S, Proietto J, McNeil J, et al. Treatment of mild to moderate obesity with laparoscopic adjustable gastric banding or an intensive medical program: a randomized trial. Ann Intern Med. 2006;144(9):625–33. PubMed PMID: 16670131.

    Article  PubMed  Google Scholar 

  56. Courcoulas AP, Goodpaster BH, Eagleton J, et al. Surgical vs medical treatments for type 2 diabetes mellitus: a randomized clinical trial. JAMA Sur. 2014;149(7):707–15.

    Article  Google Scholar 

  57. Fabbrini E, Klein S. Fundamentals of cardipmetabolic risk factor reduction: achieving and maintaining weight loss with pharmacotherapy or bariatric surgery. Clin Cornerstone. 2008;9(1):41–51.

    Article  PubMed  Google Scholar 

  58. Chang S, Stoll CT, Song J, Varela J, Eagon CJ, Colditz GA. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003–2012. JAMA Surg. 2014;149(3):275–87.

    Article  PubMed  Google Scholar 

  59. Maciejewski ML, Arterburn DE. Cost-effectiveness of bariatric surgery. JAMA. 2013;310(7):742–3.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  60. Chang S-H, Stoll CRT, Colditz GA. Cost-effectiveness of bariatric surgery: should it be universally available? Maturitas. 2011;69(3):230–8.

    Article  PubMed  Google Scholar 

  61. Wang BCM, Furnback W. Modelling the long-term outcomes of bariatric surgery: a review of cost-effectiveness studies. Best Pract Res Clin Gastroenterol. 2013;27(6):987–95.

    Article  PubMed  Google Scholar 

  62. Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, et al. The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation. Health Technol Assess. 2009;13(41):1–190, 215–357, iii-iv. PubMed PMID: 19726018.

    Article  CAS  Google Scholar 

  63. Dumon KR, Murayama KM. Bariatric surgery outcomes. Surg Clin North Am. 2011;91(6):1313–38, x. PubMed PMID: 22054156. Epub 2011/11/08. eng.

    Article  PubMed  Google Scholar 

  64. Benjamin SB. Small bowel obstruction and the Garren-Edwards gastric bubble: an iatrogenic bezoar. Gastrointest Endosc. 1988;34(6):463–7. PubMed PMID: 3234683.

    Article  CAS  PubMed  Google Scholar 

  65. Benjamin SB, Maher KA, Cattau EL Jr, Collen MJ, Fleischer DE, Lewis JH, et al. Double-blind controlled trial of the Garren-Edwards gastric bubble: an adjunctive treatment for exogenous obesity. Gastroenterology. 1988;95(3):581–8. PubMed PMID: 3294079.

    CAS  PubMed  Google Scholar 

  66. Hogan RB, Johnston JH, Long BW, Sones JQ, Hinton LA, Bunge J, et al. A double-blind, randomized, sham-controlled trial of the gastric bubble for obesity. Gastrointest Endosc. 1989;35(5):381–5. PubMed PMID: 2792672.

    Article  CAS  PubMed  Google Scholar 

  67. Kirby DF, Wade JB, Mills PR, Sugerman HJ, Kellum JM, Zfass AM, et al. A prospective assessment of the Garren-Edwards gastric bubble and bariatric surgery in the treatment of morbid obesity. Am Surg. 1990;56(10):575–80. PubMed PMID: 2221603.

    CAS  PubMed  Google Scholar 

  68. Lindor KD, Hughes RW Jr, Ilstrup DM, Jensen MD. Intragastric balloons in comparison with standard therapy for obesity—a randomized, double-blind trial. Mayo Clin Proc. 1987;62(11):992–6. PubMed PMID: 3312857.

    Article  CAS  PubMed  Google Scholar 

  69. Meshkinpour H, Hsu D, Farivar S. Effect of gastric bubble as a weight reduction device: a controlled, crossover study. Gastroenterology. 1988;95(3):589–92. PubMed PMID: 3294080.

    CAS  PubMed  Google Scholar 

  70. Zeman RK, Benjamin SB, Cunningham MB, Nauta RJ, Fleischer DF, Lewis JH, et al. Small bowel obstruction due to garren gastric bubble: radiographic diagnosis. AJR Am J Roentgenol. 1988;150(3):581–2. PubMed PMID: 3257613.

    Article  CAS  PubMed  Google Scholar 

  71. Ziessman HA, Collen MJ, Fahey FH, Ciarleglio CA, Maher KA, Cattau EL Jr, et al The effect of the Garren-Edwards Gastric bubble on solid and liquid gastric emptying. Clini Nucl Med. 1988;13(8):586–9. PubMed PMID: 3168374.

    Article  CAS  Google Scholar 

  72. Geliebter A, Westreich S, Gage D. Gastric distention by balloon and test-meal intake in obese and lean subjects. Am J Clin Nutr. 1988;48(3):592–4.

    CAS  PubMed  Google Scholar 

  73. Imaz I, Martinez-Cervell C, Garcia-Alvarez EE, Sendra-Gutierrez JM, Gonzalez-Enriquez J. Safety and effectiveness of the intragastric balloon for obesity. A meta-analysis. Obes Surg. 2008;18(7):841–6. PubMed PMID: 18459025.

    Article  PubMed  Google Scholar 

  74. Farina M, Baratta R, Nigro A, Vinciguerra F, Puglisi C, Schembri R, et al. Intragastric balloon in association with lifestyle and/or pharmacotherapy in the long-term management of obesity. Obes Surg. 2012;22(4):565–71.

    Article  PubMed  Google Scholar 

  75. Kotzampassi K, Grosomanidis V, Papakostas P, Penna S, Eleftheriadis E. 500 intragastric balloons: what Happens 5 years thereafter? Obes Surg. 2012;22(6):896–903.

    Article  PubMed  Google Scholar 

  76. Genco A, Cipriano M, Bacci V, Maselli R, Paone E, Lorenzo M, et al. Intragastric balloon followed by diet vs intragastric balloon followed by another balloon: a prospective study on 100 patients. Obes Surg. 2010;20(11):1496–500. PubMed PMID: 20661659.

    Article  PubMed  Google Scholar 

  77. Alfredo G, Roberta M, Massimiliano C, Michele L, Nicola B, Adriano R. Long-term multiple intragastric balloon treatment-a new strategy to treat morbid obese patients refusing surgery: prospective 6-year follow-up study. Surg Obes Relat Dis. 2014;10(2):307–11.

    Article  PubMed  Google Scholar 

  78. Genco A, Bruni T, Doldi SB, Forestieri P, Marino M, Busetto L, et al. BioEnterics intragastric balloon: the Italian Experience with 2,515 patients. Obes Surg. 2005;15(8):1161–4.

    CAS  Google Scholar 

  79. Halperin F, Ding S, Simonson DC, et al. Roux-en-y gastric bypass surgery or lifestyle with intensive medical management in patients with type 2 diabetes: feasibility and 1-year results of a randomized clinical trial. JAMA Surg. 2014;149(7):716–26.

    Article  PubMed  Google Scholar 

  80. Breen DM, Rasmussen BA, Kokorovic A, Wang R, Cheung GWC, Lam TKT. Jejunal nutrient sensing is required for duodenal-jejunal bypass surgery to rapidly lower glucose concentrations in uncontrolled diabetes. Nat Med. 2012;18(6):950–5.

    Article  CAS  PubMed  Google Scholar 

  81. Bradley D, Magkos F, Eagon JC, Varela JE, Gastaldelli A, Okunade AL, et al. Matched weight loss induced by sleeve gastrectomy or gastric bypass similarly improves metabolic function in obese subjects. Obesity. 2014;22(9):2026–31. PubMed PMID: 24891156. Epub 5/28/2014.

    Article  CAS  PubMed  Google Scholar 

  82. Bradley D, Magkos F, Klein S. Effects of bariatric surgery on glucose homeostasis and type 2 diabetes. Gastroenterology. 2012;143(4):897–912. PubMed PMID: 22885332. Pubmed Central PMCID: 3462491.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  83. Laferrere B, Teixeira J, McGinty J, Tran H, Egger JR, Colarusso A, et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes. J Clin Endocrinol Metab. 2008;93(7):2479–85. PubMed PMID: 18430778.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  84. Bradley D, Conte C, Mittendorfer B, Eagon JC, Varela JE, Fabbrini E, et al. Gastric bypass and banding equally improve insulin sensitivity and beta cell function. J Clin Invest. 2012;122(12):4667–74. PubMed PMID: 23187122. Pubmed Central PMCID: 3512168.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  85. Schouten R, Rijs CS, Bouvy ND, Hameeteman W, Koek GH, Janssen IM, et al. A multicenter, randomized efficacy study of the EndoBarrier gastrointestinal liner for presurgical weight loss prior to bariatric surgery. Ann Surg. 2010;251(2):236–43. PubMed PMID: 19858703.

    Article  PubMed  Google Scholar 

  86. Tarnoff M, Rodriguez L, Escalona A, Ramos A, Neto M, Alamo M, et al. Open label, prospective, randomized controlled trial of an endoscopic duodenal-jejunal bypass sleeve versus low calorie diet for pre-operative weight loss in bariatric surgery. Surg Endosc. 2009;23(3):650–6. PubMed PMID: 19067075.

    Article  CAS  PubMed  Google Scholar 

  87. Rodriguez-Grunert L, Galvao Neto MP, Alamo M, Ramos AC, Baez PB, Tarnoff M. First human experience with endoscopically delivered and retrieved duodenal-jejunal bypass sleeve. Surg Obes Relat Dis. 2008;4(1):55–9.

    Article  PubMed  Google Scholar 

  88. Escalona A, Pimentel F, Sharp A, Becerra P, Slako M, Turiel D, et al. Weight loss and metabolic improvement in morbidly obese subjects implanted for 1 year with an endoscopic duodenal-jejunal bypass liner. Ann Surg. 2012;255(6):1080–5. PubMed PMID: 22534421.

    Article  PubMed  Google Scholar 

  89. Gersin KS, Rothstein RI, Rosenthal RJ, Stefanidis D, Deal SE, Kuwada TS, et al. Open-label, sham-controlled trial of an endoscopic duodenojejunal bypass liner for preoperative weight loss in bariatric surgery candidates. Gastrointest Endosc. 2010;71(6):976–82.

    Article  PubMed  Google Scholar 

  90. Rodriguez L, Reyes E, Fagalde P, Oltra MS, Saba J, Aylwin CG, et al. Pilot clinical study of an endoscopic, removable duodenal-jejunal bypass liner for the treatment of type 2 diabetes. Diabetes Technol Ther. 2009;11(11):725–32. PubMed PMID: 19905889.

    Article  CAS  PubMed  Google Scholar 

  91. de Jonge C, Rensen S, Verdam F, Vincent R, Bloom S, Buurman W, et al. Endoscopic Duodenal-Jejunal bypass liner rapidly improves type 2 diabetes. Obes Surg. 2013;23(9):1354–60.

    Google Scholar 

  92. de Moura EG, Martins BC, Lopes GS, Orso IR, de Oliveira SL, Galvao Neto MP, et al. Metabolic improvements in obese type 2 diabetes subjects implanted for 1 year with an endoscopically deployed duodenal-jejunal bypass liner. Diabetes Technol Ther. 2012;14(2):183–9. PubMed PMID: 21932999.

    Article  PubMed  Google Scholar 

  93. Muñoz R, Escalona A. Duodenal-jejunal bypass liner to treat type 2 diabetes mellitus in morbidly obese patients. Curr Cardiol Rep. 2014;16(3):1–9.

    Article  Google Scholar 

  94. Lassle C, Laubner K, Schwacha H, Seufert J, Grueneberger JM, Fischer A, et al. Minimally invasive treatment of a duodenal perforation associated with the EndoBarrier duodenal-jejunal bypass liner. Endoscopy. 2014;46(Suppl 1):E171-2. PubMed PMID: 24756279.

    PubMed  Google Scholar 

  95. Brethauer SA, Chand B, Schauer PR, Thompson CC. Transoral gastric volume reduction as intervention for weight management: 12-month follow-up of TRIM trial. Surg Obes Relat Dis. 2012;8(3):296–303.

    Article  PubMed  Google Scholar 

  96. Abu Dayyeh BK, Rajan E, Gostout CJ. Endoscopic sleeve gastroplasty: a potential endoscopic alternative to surgical sleeve gastrectomy for treatment of obesity. Gastrointest Endosc. 2013;78(3):530–5.

    Article  PubMed  Google Scholar 

  97. Legner A, Altorjay A, Juhasz A, Stadlhuber R, Reich V, Hunt B, et al. Transoral mucosal excision sutured gastroplasty: a pilot study for gerd and obesity with two-year follow-up. Surg Innov. 2014;21(5):456–63. PMID:24623807.

    Article  PubMed Central  PubMed  Google Scholar 

  98. Sullivan S, Stein R, Jonnalagadda S, Mullady D, Edmundowicz S. Aspiration therapy leads to weight loss in obese subjects: a pilot study. Gastroenterology. 2013;145(6):1245–52.e5.

    Article  PubMed Central  PubMed  Google Scholar 

  99. Machytka E, Buzga M, Kupka T, Bojkova M. Aspiration therapy in super obese patients—pilot trial. Gastrointest Endosc. 2014;79(5S):AB264-AB5.

    Google Scholar 

  100. Marinos G, Eliades C, Raman Muthusamy V, Greenway F. Weight loss and improved quality of life with a nonsurgical endoscopic treatment for obesity: clinical results from a 3-and 6-month study. Surg Obes Relat Dis. 2014. doi:10.1016/j.soard.2014.03.005

    Google Scholar 

  101. Ryou M, Cantillon-Murphy P, Azagury D, Shaikh SN, Ha G, Greenwalt I, et al. Smart Self-Assembling MagnetS for ENdoscopy (SAMSEN) for transoral endoscopic creation of immediate gastrojejunostomy (with video). Gastrointest Endosc. 2011;73(2):353–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shelby Sullivan MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sullivan, S. (2015). Endoscopic Treatment of Obesity. In: Jonnalagadda, S. (eds) Gastrointestinal Endoscopy. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2032-7_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4939-2032-7_4

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2031-0

  • Online ISBN: 978-1-4939-2032-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics