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Cytology of Extracervical Adenocarcinoma

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Glandular Lesions of the Uterine Cervix

Part of the book series: Essentials in Cytopathology ((EICP,volume 19))

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Abstract

Although extrauterine adenocarcinoma is rarely identified in cervical cytology, the possibility of a non-uterine tumor should always be excluded in the event of adenocarcinoma in a cervical sample. In this chapter features of extrauterine adenocarcinomas, known to involve the cervix or known to shed into the cervical cytology sample, are reviewed. An approach to the work-up of such samples is provided.

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References

  1. Gupta D, Balsara G. Extrauterine malignancies. Role of Pap smears in diagnosis and management. Acta Cytol. 1999;43(5):806–13.

    Article  CAS  PubMed  Google Scholar 

  2. Ng AB, Reagan JW, Hawliczek S, Wentz BW. Significance of endometrial cells in the detection of endometrial carcinoma and its precursors. Acta Cytol. 1974;18(5):356–61.

    CAS  PubMed  Google Scholar 

  3. Mazur MT, Hsueh S, Gersell DJ. Metastases to the female genital tract. Analysis of 325 cases. Cancer. 1984;53(9):1978–84.

    Article  CAS  PubMed  Google Scholar 

  4. Lemoine NR, Hall PA. Epithelial tumors metastatic to the uterine cervix. A study of 33 cases and review of the literature. Cancer. 1986;57(10):2002–5.

    Article  CAS  PubMed  Google Scholar 

  5. Mulvany N, Ostor A. Microinvasive adenocarcinoma of the cervix: a cytohistopathologic study of 40 cases. Diagn Cytopathol. 1997;16(5):430–6.

    Article  CAS  PubMed  Google Scholar 

  6. Perez-Montiel D, Serrano-Olvera A, Salazar LC, Cetina-Perez L, Candelaria M, Coronel J, et al. Adenocarcinoma metastatic to the uterine cervix: a case series. J Obstet Gynaecol Res. 2012;38(3):541–9.

    Article  PubMed  Google Scholar 

  7. McCluggage WG, Hurrell DP, Kennedy K. Metastatic carcinomas in the cervix mimicking primary cervical adenocarcinoma and adenocarcinoma in situ: report of a series of cases. Am J Surg Pathol. 2010;34(5):735–41.

    PubMed  Google Scholar 

  8. Malpica A, Deavers MT. Ovarian low-grade serous carcinoma involving the cervix mimicking a cervical primary. Int J Gynecol Pathol. 2011;30(6):613–9.

    Article  PubMed  Google Scholar 

  9. Matsushita H, Fukase M, Takayanagi T, Ikarashi H. Metastatic gastric cancer mimicking an advanced cervical cancer: a case report. Eur J Gynaecol Oncol. 2011;32(2):199–200.

    CAS  PubMed  Google Scholar 

  10. Kashimura M, Kashimura Y, Matsuyama T, Tsukamoto N, Sugimori H, Taki I. Adenocarcinoma of the uterine cervix metastatic from primary stomach cancer. Cytologic findings in six cases. Acta Cytol. 1983;27(1):54–8.

    CAS  PubMed  Google Scholar 

  11. Wang H, Chen PC. Primary serous peritoneal carcinoma presenting first on a routine papanicolaou smear: a case report. Acta Cytol. 2010;54(4):623–6.

    PubMed  Google Scholar 

  12. Wilbur DC, Henry MR, editors. College of American Pathologists practical guide to gynecologic cytopathology: morphology, management, and molecular methods. Northfield: College of American Pathologists; 2008.

    Google Scholar 

  13. Tepeoglu M, Ozen O, Ayhan A. Ovarian serous borderline tumor detected by conventional papanicolaou smear: a case report. Acta Cytol. 2013;57(1):96–9.

    Article  PubMed  Google Scholar 

  14. McKee GT. Cytopathology of the Breast. New York: Oxford University Press; 2002.

    Google Scholar 

  15. Rau AR, Saldanha P, Raghuveer CV. Metastatic lobular mammary carcinoma diagnosed in cervicovaginal smears: a case report. Diagn Cytopathol. 2003;29(5):300–2.

    Article  PubMed  Google Scholar 

  16. Haji BE, Kapila K, Francis IM, Temmim L, Ahmed MS. Cytomorphological features of metastatic mammary lobular carcinoma in cervicovaginal smears: report of a case and review of literature. Cytopathology. 2005;16(1):42–8.

    Article  CAS  PubMed  Google Scholar 

  17. Pambuccian SE, Bachowski GJ, Twiggs LB. Signet ring cell lobular carcinoma of the breast presenting in a cervicovaginal smear. A case report. Acta Cytol. 2000;44(5):824–30.

    Article  CAS  PubMed  Google Scholar 

  18. Pirog EC, Kleter B, Olgac S, Bobkiewicz P, Lindeman J, Quint WG, et al. Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. Am J Pathol. 2000;157(4):1055–62.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  19. Yemelyanova A, Vang R, Seidman JD, Gravitt PE, Ronnett BM. Endocervical adenocarcinomas with prominent endometrial or endomyometrial involvement simulating primary endometrial carcinomas: utility of HPV DNA detection and immunohistochemical expression of p16 and hormone receptors to confirm the cervical origin of the corpus tumor. Am J Surg Pathol. 2009;33(6):914–24.

    Article  PubMed  Google Scholar 

  20. Kong CS, Beck AH, Longacre TA. A panel of 3 markers including p16, ProExC, or HPV ISH is optimal for distinguishing between primary endometrial and endocervical adenocarcinomas. Am J Surg Pathol. 2010;34(7):915–26.

    Article  PubMed  Google Scholar 

  21. Park KJ, Kiyokawa T, Soslow RA, Lamb CA, Oliva E, Zivanovic O, et al. Unusual endocervical adenocarcinomas: an immunohistochemical analysis with molecular detection of human papillomavirus. Am J Surg Pathol. 2011;35(5):633–46.

    Article  PubMed  Google Scholar 

  22. Yemelyanova A, Ji H, Shih Ie M, Wang TL, Wu LS, Ronnett BM. Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases. Am J Surg Pathol. 2009;33(10):1504–14.

    Article  PubMed  Google Scholar 

  23. McCluggage WG, Sumathi VP, McBride HA, Patterson A. A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol. 2002;21(1):11–5.

    Article  PubMed  Google Scholar 

  24. Zaino RJ. Symposium part I: adenocarcinoma in situ, glandular dysplasia, and early invasive adenocarcinoma of the uterine cervix. Int J Gynecol Pathol. 2002;21(4):314–26.

    Article  PubMed  Google Scholar 

  25. Kamoi S, AlJuboury MI, Akin MR, Silverberg SG. Immunohistochemical staining in the distinction between primary endometrial and endocervical adenocarcinomas: another viewpoint. Int J Gynecol Pathol. 2002;21(3):217–23.

    Article  PubMed  Google Scholar 

  26. Kurman RJ, Ellenson LH, Ronnett BM. Blausteins’s pathology of the female genital tract. 6th ed. New York: Springer; 2011.

    Book  Google Scholar 

  27. Fatima N, Cohen C, Lawson D, Siddiqui MT. TTF-1 and Napsin A double stain: a useful marker for diagnosing lung adenocarcinoma on fine-needle aspiration cell blocks. Cancer Cytopathol. 2011;119(2):127–33.

    Article  CAS  PubMed  Google Scholar 

  28. Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod Pathol. 2000;13(9):962–72.

    Article  CAS  PubMed  Google Scholar 

  29. Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol. 2003;27(3):303–10.

    Article  PubMed  Google Scholar 

  30. Vang R, Gown AM, Wu LS, Barry TS, Wheeler DT, Yemelyanova A, et al. Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol. 2006;19(11):1421–8.

    CAS  PubMed  Google Scholar 

  31. Chu PG, Schwarz RE, Lau SK, Yen Y, Weiss LM. Immunohistochemical staining in the diagnosis of pancreatobiliary and ampulla of Vater adenocarcinoma: application of CDX2, CK17, MUC1, and MUC2. Am J Surg Pathol. 2005;29(3):359–67.

    Article  PubMed  Google Scholar 

  32. Yang HS, Tamayo R, Almonte M, Horten B, DaSilva M, Gangi M, et al. Clinical significance of MUC1, MUC2 and CK17 expression patterns for diagnosis of pancreatobiliary arcinoma. Biotech Histochem. 2012;87(2):126–32.

    Article  CAS  PubMed  Google Scholar 

  33. Ordonez NG. Value of GATA3 immunostaining in tumor diagnosis: a review. Adv Anat Pathol. 2013;20(5):352–60.

    Article  CAS  PubMed  Google Scholar 

  34. McCluggage WG. Immunohistochemistry in the distinction between primary and metastatic ovarian mucinous neoplasms. J Clin Pathol. 2012;65(7):596–600.

    Article  PubMed  Google Scholar 

  35. Chu PG, Chung L, Weiss LM, Lau SK. Determining the site of origin of mucinous adenocarcinoma: an immunohistochemical study of 175 cases. Am J Surg Pathol. 2011;35(12):1830–6.

    Article  PubMed  Google Scholar 

  36. Greco FA, Lennington WJ, Spigel DR, Hainsworth JD. Molecular profiling diagnosis in unknown primary cancer: accuracy and ability to complement standard pathology. J Natl Cancer Inst. 2013;105(11):782–90.

    Article  CAS  PubMed  Google Scholar 

  37. Greco FA, Oien K, Erlander M, Osborne R, Varadhachary G, Bridgewater J, et al. Cancer of unknown primary: progress in the search for improved and rapid diagnosis leading toward superior patient outcomes. Ann Oncol. 2012;23(2):298–304.

    Article  CAS  PubMed  Google Scholar 

  38. Handorf CR, Kulkarni A, Grenert JP, Weiss LM, Rogers WM, Kim OS, et al. A multicenter study directly comparing the diagnostic accuracy of gene expression profiling and immunohistochemistry for primary site identification in metastatic tumors. Am J Surg Pathol. 2013;37(7):1067–75.

    Article  PubMed  Google Scholar 

  39. Kinde I, Bettegowda C, Wang Y, Wu J, Agrawal N, Shih IM, et al. Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers. Sci Transl Med. 2013;5(167):167ra4.

    Article  PubMed Central  PubMed  Google Scholar 

  40. Ordonez NG. Value of PAX 8 immunostaining in tumor diagnosis: a review and update. Adv Anat Pathol. 2012;19(3):140–51.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA

    Rosemary H. Tambouret MD & David C. Wilbur MD

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  1. Rosemary H. Tambouret MD
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  2. David C. Wilbur MD
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Tambouret, R.H., Wilbur, D.C. (2015). Cytology of Extracervical Adenocarcinoma. In: Glandular Lesions of the Uterine Cervix. Essentials in Cytopathology, vol 19. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-1989-5_7

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  • DOI: https://doi.org/10.1007/978-1-4939-1989-5_7

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-1988-8

  • Online ISBN: 978-1-4939-1989-5

  • eBook Packages: MedicineMedicine (R0)

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