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Instability: Dynamic Loading Models

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Post-Traumatic Arthritis

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Abstract

Joint instability consistently leads to osteoarthritis. Instability represents excessive translation or rotation of the articulating structures causing articular stresses to be transmitted at abnormal rates and leading to an expanded footprint of joint contact. Excessive stress rates have been shown to be particularly damaging to cartilage in multiple isolated cartilage preparations. In this chapter, basic scientific evidence primarily generated from cadaveric macromechanical experiments, computational modeling, living-tissue preparations, and animal in vivo preparations are presented. Instability causes significant increases in contact stress rates which extrapolate into abnormal cartilage tissue strain. In vivo models demonstrate correspondence between instability and joint degeneration.

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Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, IU Health Methodist Hospital, Indiana University, North Senate Boulevard, Suite 535, Indianapolis, IN, 46202, USA

    Todd McKinley M.D.

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  1. Todd McKinley M.D.
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Correspondence to Todd McKinley M.D. .

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Editors and Affiliations

  1. Professor, Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Steven A. Olson, MD

  2. Laszlo Ormandy Professor, Department of Orthopedic Surgery, Duke University Medical Center, Durham, North Carolina, USA

    Farshid Guilak, PhD

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McKinley, T. (2015). Instability: Dynamic Loading Models. In: Olson, MD, S., Guilak, PhD, F. (eds) Post-Traumatic Arthritis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-7606-2_9

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  • DOI: https://doi.org/10.1007/978-1-4899-7606-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-7605-5

  • Online ISBN: 978-1-4899-7606-2

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