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Pulmonary Vascular Control Mechanisms

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ARDS Acute Respiratory Distress in Adults

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Abstract

The important contribution of the pulmonary vasculature to the expression of acute lung injury was recognized in early clinical and experimental studies of the syndrome of acute respiratory distress in adults (ARDS). Acute pulmonary hypertension was shown to be an important early feature with adverse prognostic implications, and persistence of the hypertension was found to be associated with structural vascular changes. More recently, it has been recognized that there is also a profound loss of pulmonary and systemic reactivity, with substantial implications for lung defense, gas exchange, etc.

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Authors
  1. Nigel A. M. Paterson
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  2. David G. McCormack
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Editors and Affiliations

  1. National Heart & Lung Institute, USA

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  2. Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK

    Timothy W. Evans MD, FRCP, PhD (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine) (Reader in Critical Care Medicine, Consultant in Thoracic and Intensive Care Medicine)

  3. University of Edinburgh, Royal Infirmary, Lauriston Place, Edinburgh, EH3 9YW, UK

    Christopher Haslett FRCP, FRCP (Edin) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories) (Professor of Respiratory Medicine, Chairman of the Department of Medicine (RIE) and Director of the Rayne Laboratories)

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Paterson, N.A.M., McCormack, D.G. (1996). Pulmonary Vascular Control Mechanisms. In: Evans, T.W., Haslett, C. (eds) ARDS Acute Respiratory Distress in Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3430-7_17

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  • DOI: https://doi.org/10.1007/978-1-4899-3430-7_17

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