ARDS Acute Respiratory Distress in Adults

  • Timothy W. Evans
  • Christopher Haslett

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Introduction and Overview

    1. Front Matter
      Pages 1-1
    2. John F. Murray
      Pages 3-12
    3. Molly L. Osborne, Robert J. Meyer
      Pages 13-23
    4. Nicholas P. Curzen, Christopher Haslett, Timothy W. Evans
      Pages 25-35
    5. Bryan Corrin
      Pages 37-46
  3. Basic Mechanisms

    1. Front Matter
      Pages 47-47
    2. Christopher Haslett
      Pages 49-68
    3. Polly E. Parsons
      Pages 69-84
    4. Daniel R. Smith, Robert M. Strieter, Steven L. Kunkel
      Pages 85-97
    5. G. Scott Worthen, Gregory P. Downey
      Pages 99-114
    6. S. Craig Stocks, Ian Dransfield
      Pages 115-137
    7. Caroline A. Owen, Edward J. Campbell
      Pages 139-165
    8. John M. C. Gutteridge, Gregory J. Quinlan
      Pages 167-195
    9. Elizabeth L. Aronsen, John M. Shannon
      Pages 197-213
    10. Patricia J. Sime, Jack Gauldie
      Pages 215-231
    11. Galen B. Toews
      Pages 233-248
  4. Physiology

    1. Front Matter
      Pages 249-249
    2. Peter D. Macnaughton
      Pages 251-262
    3. Patricia L. Haslam
      Pages 263-296

About this book

Introduction

Great progress has been made since the first description of the acute respiratory distress syndrome by the Denver group in 1967 (Lancet). Although we introduced the term 'adult respiratory distress syndrome' in our second and more detailed description of the syndrome (ehest, 1971), this was probably amistake for the simple reason that children also suffer the same syndrome fo11owing acute lung insults. Today, the syndrome of acute respiratory distress in adults (ARDS) is recognized as a worldwide problem, but the prevalence of disease varies in different parts of the world. A huge amount of research has focused on the mechanisms of acute lung injury and yet the exact sequence of events and media tors in inflammatory cascade, which result in acute respiratory failure from ARDS, is not known but many possibilities exist. The definition of ARDS has been gradua11y modified in recent years and investigators around the world are now co11aborating in order to establish more uniform concepts in identification, risk factors and mechanisms of lung injury, which someday will result in improved approaches to management. Already, at least some centers are showing improved outcomes in ARDS, achieving an approximate 60% survival rate. In the past, most large series documented only about a 40% survivability taking a11 causes of ARDS. This apparent progress is likely attributable to more meticulous and disciplined care than any specific pharmacologic attack on the basic mechanism resulting in ARDS.

Keywords

Acute respiratory distress syndrome (ARDS) care children inflammation lung management outcome pharmacology research respiratory failure stress

Editors and affiliations

  • Timothy W. Evans
    • 1
    • 2
  • Christopher Haslett
    • 3
  1. 1.National Heart & Lung InstituteUSA
  2. 2.Royal Brompton HospitalLondonUK
  3. 3.University of EdinburghRoyal InfirmaryEdinburghUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-3430-7
  • Copyright Information Springer Science+Business Media New York 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-412-56910-4
  • Online ISBN 978-1-4899-3430-7
  • About this book
Industry Sectors
Biotechnology
Pharma