Abstract
The diagnostic or therapeutic efficacy of a radiopharmaceutical is highly dependent on its bio-distribution within the body after administration. Unintended alteration of this biodistribution can lead to sub-optimal outcome of a nuclear medicine procedure. It is highly likely that most patients will be taking some form of medication, and the possible effects of these drugs on the biodistribution of radiopharmaceuticals need to be considered. Therefore, an awareness of the potentially important interactions between radiopharmaceuticals and drugs is important for nuclear medicine departments. Such knowledge can be used to prevent occurrence of potentially detrimental effects by modifying the patient’s drugs before the procedure, thereby reducing the possibility of alteration in radiopharmaceutical biodistribution.
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References
Grayson, R.R. (1960) Factors which influence the radioactive iodine thyroidal uptake test. Am. J. Med., 28, 397–415.
Callahan, R.J. and Rabito, C.A. (1990) Radiolabelling of erythrocytes with technetium-99m: role of band-3 protein in the transport of pertechnetate across the cell membrane. J. Nucl. Med., 31, 2004–10.
Hicks, R.J., Eu, P. and Arkles, L.B. (1992) Efficiency : of labelling red blood cells with technetium-99m after dipyridamole infusion for thallium stress testing. Eur. J. Nucl. Med., 19, 1050–3.
Hladik, W.B., Ponto, J.A., Lentle, B.C. and Laven, D.L. (1987) Iatrogenic alterations in the bio-distribution of radiotracers as a result of drug therapy: reported instances, in Essentials of Nuclear Medicine Science (eds W.B. Hladik and G.B. Saha), Williams and Wilkins, Baltimore, pp. 189–219.
Hesslewood, S. and Leung, E. (1994) Drug interaction with radiopharmaceuticals. Eur. J. Nucl. Med., 21, 348–56.
Sampson, C.B. and Cox, P.H. (1994) Effect of patient medication and other factors on the biodistribution of radiopharmaceuticals, in Textbook of Radio-pharmacy Theory and Practice (ed. C.B. Sampson), Gordon and Breach Science Publishers, pp. 215–27.
Hladik, W.B., Nigg, K.K. and Rhodes, B.A. (1982) Drug-induced changes in the biologic distribution of radiopharmaceuticals. Semin. Nucl. Med., 12, 184–210.
Leung, S.C.E. and Hesslewood, S.R. (1994) Use of drugs to enhance nuclear medicine studies, in Textbook of Radiopharmacy Theory and Practice (ed. C.B. Sampson), Gordon and Breach Science Publishers, pp. 225–41.
Pennell, D.J. (1994) Pharmacological cardiac stress: when and how ? Nucl. Med. Commun., 15, 578–85.
Smits, P., Corstens, F.H.M., Aengevaer, W.R.M. et al. (1991) False-negative dipyridamole thallium-201 myocardial imaging after caffeine infusion. J. Nucl. Med., 32, 1538–41.
Jacobson, A.F., Cerqueria, M.D., Raisys, V. et al. (1994) Serum caffeine levels after 24 hours of caffeine abstention: observations on clinical patients undergoing myocardial perfusion imaging with dipyridamole or adenosine. Eur. J. Nucl. Med., 21, 23–6.
Young, M., Pan, W., Wiesner, J. et al. (1994) Characterization of arbutamine: a novel catecholamine stress agent for diagnosis of coronary artery disease. Drug Dev. Res., 32, 19–28.
Sandler, E.D., Parisi, M.T. and Hattner, R.S. (1991) Duration of etidronate effect demonstrated by serial bone scintigraphy. J. Nucl. Med., 32, 1782–4.
Hommeyer, S.H., Varney, D.M. and Eary, J.F. (1992) Skeletal non-visualization in a bone scan secondary to intravenous etidronate therapy. J. Nucl. Med., 33, 748–50.
Pecherstorfer, M., Schilling, T., Janisch, S. et al. (1993) Effect of clodronate treatment on bone scintigraphy in metastatic breast cancer. J. Nucl. Med., 34,1039–44.
Koyano, H., Schimizu, T. and Shishiba, Y. (1995) The biphosphonate dilemma. J. Nucl. Med., 36, 705.
Solanki, K.K., Bomanji, J., Moves, J. et al. (1992) A pharmacological guide to medicines which interfere with the biodistribution of radiolabeled meta-iodobenzylguanidine (MIBG). Nucl. Med. Commun., 13, 513–21.
Mazière, B. and Mazière, M. (1990) Where have we got with neuroreceptor mapping of the human brain? Eur. J. Nucl. Med., 16, 817–35.
Verhoeff, N.P.L.G. (1991) Pharmacological implications for neuroreceptor imaging. Eur. J. Nucl. Med., 18, 482–502.
Kerwin, R.W. and Pilowsky, L.S. (1995) Traditional receptor theory and its application to neuroreceptor measurements in functional imaging. Eur. J. Nucl. Med., 22, 699–710.
Levin, J.M., Holman, B.L., Mendelson, J.H. et al (1994) Gender differences in cerebral perfusion in cocaine abuse: technetium 99m-HMPAO SPECT study of drug abusing women. J. Nucl. Med., 35, 1902–9.
Levin, J.M., Mendelson, J.H., Holman, B. et al. (1995) Improved regional blood flow in chronic cocaine polydrug users treated with buprenorphine. J. Nucl. Med., 36, 1211–15.
Srivastava, S.C. and Chervu, L.R. (1984) Radionuclide labeled red blood cells: current status and future prospects. Semin. Nucl. Med., 14, 68–82.
Millar, A.M., Wathen, C.G. and Muir, A.L. (1983) Failure in labelling of red blood cells with 99mTc: interaction between intravenous cannulae and stannous pyrophosphate. Eur. J. Nucl. Med., 8, 502–41.
Hambye, A.S., Vandermeiren, R., Vervaet, A. et al. (1995) Failure to label red blood cells adequately in daily practice using an in vivo method: methodological and clinical considerations. Eur. J. Nucl. Med., 22, 61–67.
Eising, E.G. and Sciuk, J. (1995) Failure to label red blood cells adequately in daily practice using an in vivo method: methodological and clinical considerations. Eur. J. Nucl. Med., 22, 587.
Chung, C.J., Hicklin, O.A., Payan, J.M. et al. (1991) Indium-Ill labelled leukocyte scan in detection of synthetic vascular graft infection: the effect of antibiotic treatment. J. Nucl. Med., 32, 13–15.
Datz, F.L. and Thorne, D.A. (1986) Effect of antibiotic therapy on the sensitivity of indium-Ill labelled leukocyte scans. J. Nucl. Med., 27, 1849–53.
Blake, G.M., Lewington, V.J., Fleming, J.S. et al. (1988) Modification by nifedipine of 131I-meta-iodobenzylguanidine kinetics in malignant phaeochromocytoma. Eur. J. Nucl. Med., 14, 345–8.
Koong, S.S., Movius, E.G., Keenan, A.M. et al. (1995) The effects of lithium in radioiodine therapy of metastatic well differentiated thyroid carcinoma. J. Nucl. Med., 36,15P.
Flynn, B.M. and Treves, S.T. (1987) Diffuse hepatic uptake of technetium-99m methylene dipho sphonate in a patient receiving high-dose methotrexate. J. Nucl. Med., 28, 532–4.
Lutrin, C.L., McDougall, I.R. and Goris, M.I. (1978 Intense concentration of Tc-99m pyrophosphate ir the kidneys of children treated with chemo therapeutic drugs for malignant disease. Radiology 128, 165–7.
Bekerman, C., Pavel, D.G., Bitran, U. et al. (1984) The effects of inadvertent administration of antineoplastic agents prior to Ga-67 injection: concise communication. J. Nucl. Med., 25, 430–35.
Carrie, I., Estorch, M. and Löpez-Pousa, A. (1996 Assessing anthracycline cardiotoxicity in the 1990s Eur. J. Nucl. Med., 23, 359–64.
Wang, T.S., Fawwaz, R.A., Esser, P.D. et al. (1978) Altered body distribution of Tc-99m pertechnetate in iatrogenic hyperaluminaemia. J. Nucl. Med., 19 381–3.
Bobinet, D.D., Sevrin, R., Zurbriggen, M.T. et al (1974) Lung uptake of 99mTc-sulphur colloid in patient exhibiting presence of Al3+ in plasma. J. Nucl Med., 15, 1220–2.
Zimmer, A.M. and Pavel, D.G. (1978) Expérimenta investigations of the possible cause of liver appearance during bone scanning. Radiology, 126, 813–16.
Byun, H.H., Rodman, S.G. and Chung, K.E. (1976) Soft-tissue concentration of 99mTc-phosphates associated with injections of iron dextran complex. J. Nucl. Med., 17, 374–5.
Choy, D., Murray, I.P.C. and Hoschl, R. (1981) The effect of iron on the biodistribution of bone scanning agents in humans. Radiology, 140, 197–202.
Further Reading
Laven, D.L., Clanton, J.A., Hladik, W.B. and Shaw, S.M Pharmacological Alterations in the Bioroutingl Performance of Radiopharmaceuticals, Vols 1–4. Gammascar Consultants, Bay Pines, Florida 33504–4098, USA
Swanson, D.P., Chilton, H.M. and Thrall, J.H. (1990) Pharmaceuticals in Medical Imaging. Macmillan Publishing Co., New York.
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Hesslewood, S.R. (1998). Interactions. In: Maisey, M.N., Britton, K.E., Collier, B.D. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3356-0_46
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DOI: https://doi.org/10.1007/978-1-4899-3356-0_46
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