Abstract
The brain is protected from internal and external injury by special and specific physiological barriers. These are of three main types: (i) the blood-brain barrier (BBB) that separates the blood from the brain parenchyma; (ii) the blood-CSF barrier between the blood and the cerebrospinal fluid (CSF); and (iii) the CSF-brain barrier separating the CSF from the brain parenchyma [1].
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References
Costa, D.C. (1994) The blood-brain barrier, in Nuclear Medicine in Clinical Diagnosis and Treatment (eds I.P.C. Murray and P.J. Ell), Churchill Livingstone, Edinburgh, pp. 449–55.
Morgan, G.F. and Costa, D.C. (1993) Radiopharmaceuticals for conventional blood-brain barrier and brain perfusion studies, in New Trends in Nuclear Neurology and Psychiatry (eds D.C. Costa, G.F. Morgan and N.A. Lassen), John Libbey and Company Ltd, London, pp. 65–84.
Schmidbauer, M., Podreka, I., Wimberger, D. et al. (1991) SPECT and MR Imaging in Herpes Simplex Encephalitis. J. Comput. Assist. Tomogr., 15, 812–15.
Henkes, H., Huber, C., Hierholzer, J. et al. (1991) Temporal-medial hot spot in HMPAO/SPET: key finding in acute herpes encephalitis. Radiology, 18(P), 173.
Kendell, R.E. (1991) Chronic fatigue, viruses, and depression. Lancet, 337, 160–2.
Palca, J. (1991) On the track of an elusive disease. Science, 254, 1726–8.
Ray, C. (1991) Chronic fatigue syndrome and depression: conceptual and methodological ambiguities. Psychol. Med., 21, 1–9.
Ichise, M., Salit, I., Abbey, S. et al. (1992) Assessment of regional cerebral perfusion by 99Tcm-HMPAO/SPECT in Chronic Fatigue Syndrome. Nucl. Med. Commun., 13, 767–72.
Schwartz, R.B., Komaroff, A.L., Garada, B.M. et al. (1994) SPECT Imaging of the brain: comparison of findings in patients with Chronic Fatigue Syndrome, AIDS Dementia Complex, and major unipolar depression. Am. J. Radiol, 162, 943–51.
Costa, D.C., Tannock, C. and Brostoff, J. (1995) Brainstem perfusion is impaired in patients with myalgic encephalomyelitis/chronic fatigue syndrome. Q. J. Med., 88, 767–73.
Ell, P.J., Costa, D.C. and Harrison, M. (1987) Imaging cerebral damage in HIV infection. Lancet, ii, 569–70.
Pohl, P., Vogl, G. and Fill, H. (1988) Single-photon emission computed tomography in AIDS dementia complex. J. Nucl. Med., 29, 1382–6.
Costa, D.C., Ell, P.J., Burns, A. et al. (1988) CBF tomograms with [99mTc]-HM-PAO in patients with dementia (Alzheimer type and HIV) and Parkinson’s disease — Initial results. J. Cereb. Blood Flow Metab., 8, S109–15.
Tatsch, K., Schielke, E., Einhaulp, K.M. et al. (1989) 99mTc-HMPAO-SPECT in patients with HIV infection: a comparison with neurological, CT and MRI findings. Eur. J. Nucl. Med., 15, 418.
Maini, C.L., Pigorini, F., Pau, F.M. et al. (1989) 99mTc-HM-PAO brain SPECT in acquired immunodeficiency syndrome (AIDS). Eur. J. Nucl. Med., 15, 418.
Rottenberg, D.A., Moeller, J.R., Strother, S.C. et al. (1987) The metabolic pathology of the AIDS dementia complex. Ann. Neurol., 22, 700–6.
Brunetti, A., Berg, G., DiChiro, X. et al. (1989) Reversal of brain metabolic abnormalities following treatment of AIDS dementia complex with 3′-azido-2′,3′-thymidine AZT, zidovudine: a PET-FDG study. J. Nucl. Med., 30, 581–90.
Ramsey, R.G. (1994) Central nervous system infections in the immunocompromised and immunocompetent patient, in Syllabus: Special Course in Neuroradiology — Clinical Approach and Management for Diagnostic Imaging (eds G. Forbes, R.M. Quencer and H.R. Hansberger), Radiological Society of North America, pp. 181–9.
Naidich, T.P. (1994) Pathology of adult intracranial neoplasms: useful interpretation of mass, in Syllabus: Special Course in Neuroradiology — Clinical Approach and Management for Diagnostic Imaging (eds G. Forbes, R.M. Quencer and H.R. Hansberger), Radiological Society of North America, pp. 83–95.
Chinn, R.J.S., Wilkinson, I.D., Hall-Craggs, M. et al. (1994) Spectroscopic tissue diagnosis of CNS mass lesions in HIV infection, in Proceedings of The Society of Magnetic Resonance, 2nd Meeting, vol. 1, 133.
O’Malley, J.P., Ziessman, H.A., Kumar, P.N. et al. (1994) Diagnosis of intracranial lymphoma in patients with AIDS: value of 201-T1 single-photon emission computed tomography. Am. J. Roentgenol., 163, 417–21.
Costa, D.C., Gacinovic, S. and Miller, R.F. (1995) Radionuclide brain imaging in Acquired Immunodeficiency Syndrome (AIDS). Q. J. Nucl. Med., 39, 243–9.
Loeffler, J.S., Siddon, R.L., Wen, P.Y. et al. (1989) Stereotactic radiosurgery of the brain using a standard linear accelerator: a study of early and late effects. Radiother. Oncol., 17, 311–21.
Burke, J.W., Podrasky, A.E. and Bradley, W.G. (1990) Meninges: benign postoperative enhancement on MR images. Radiology, 174, 99–102.
Dischino, D.D., Welch, M.J., Kilbourn, M.R. and Raichle, M.E. (1983) Relationship between lipophihcity and brain extraction of C-11-labelled radiopharmaceuticals. J. Nucl Med., 24, 1030–8.
Warburg, O. (1930) The Metabolism of Tumours, Arnold Constable, London, pp. 75–327.
Reivich, M., Kuhl, D., Wolf, A. et al. (1979) The (18F)fluorodeoxyglucose method for the measurement of local cerebral glucose utilization in man. Circ. Res., 44, 127–37.
Di Chiro, G. (1986) Positron emission tomography using [18F]fluorodeoxyglucose in brain tumours: a powerful diagnostic and prognostic tool. Invest. Radiol., 22, 360–71.
Glantz, M.J., Hoffman, J.M., Coleman, R.E. et al. (1991) Identification of early recurrence of primary central nervous system tumours by [18F] Fluorodeoxyglucose positron emission tomography. Ann. Neurol., 29, 347–55.
Valk, P.E., Budinger, T.F., Levin, V.A. et al. (1988) PET of malignant cerebral rumours after interstitial brachytherapy: démonstration of metabolic activity and correlation with clinical outcome. J. Neurosurg., 69, 830–8.
Mosskin, M., Von Holst, H., Bergstrom, M. et al. (1987), Positron emission tomography with 11C-methionine and computed tomography of intracranial tumours compared with histopathologic examination of multiple biopsies. Acta Radiol., 28, 505–9.
Schwartz, R.B., Carvalho, P.A., Alexander, E., III et al. (1992) Radiation necrosis versus high-grade recurrent glioma: differentiation by using dual-isotope SPECT with 201T1 and 99mTc-HMPAO. Am. J. Nucl. Radiol., 12, 1187–92.
Kim, K.T., Black, K.L., Marciano, D. et al. (1990) Thallium-201 SPECT imaging of brain tumours: methods and results. J. Nucl. Med., 31, 965–9.
Maier-Hauff, K., Barzen, G.S. and Gottschalk, H. (1991) Value of Tl-201 imaging in cerebral lesions: emission CT with autoradiography. Radiology, 185(P), 232.
Krishna, L., Slizofski, W.J., Katsetos, C.D. et al. (1992) Abnormal intracerebral thallium localization in a bacterial brain abscess. J. Nucl. Med., 33, 2017–19.
Further Reading
Costa, D.C., Morgan, G.F. and Lassen, N.A. (eds) (1993) New Trends in Nuclear Neurology and Psychiatry, John Libbey, London.
Harrison, M.J.G. and McArthur, J.C. (eds) (1995) AIDS and Neurology, Churchill Livingstone, Edinburgh.
Wise, M.G. and Gray, K.F. (1994) Delirium, Dementia, and Amnestic Disorders, in The American Psychiatric Press Textbook of Psychiatry, 2nd edn (eds R.E. Hales, S.C. Yudofsky and J.A. Talbott), American Psychiatric Press, Inc. Washington, DC and London, pp. 313–53.
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Costa, D.C., Ell, P.J. (1998). Infection and oncology. In: Maisey, M.N., Britton, K.E., Collier, B.D. (eds) Clinical Nuclear Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3356-0_25
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DOI: https://doi.org/10.1007/978-1-4899-3356-0_25
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