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Structure and tRNAPhe-Binding Properties of the Zinc Finger Motifs of HIV-1 Nucleocapsid Protein

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Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

Part of the book series: NATO ASI Series ((NSSB,volume 325))

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Abstract

The nucleocapsid protein NCp7 of the human immunodefiency virus type 1 (HIV-1) is a 72 amino acid peptide containing two zinc fingers of the type CX2CX4HX4C. NCp7 is thought to be a key component of the retrovirus life cycle since it activates Doth viral RNA dimerization and replication primer tRNALys,3 annealing to the initiation site of reverse transcription1,2. NCp7 constitutes thus a potential target for antiviral therapy.

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References

  1. J.L. Darlix, C. Gabus, M.T. Nugeyre, F. Clavel, and F. Barré-Sinoussi J. Mol. Biol. 216:689–699 (1990).

    Article  PubMed  CAS  Google Scholar 

  2. C. Barat, V. Lullien, O. Schatz, G. Keith, M.T. Nugeyre, F. Grüninger-Leitch, F. Barré-Sinoussi, S.F.J. Le Grice, and J.L. Darlix, Embo J.8:3279–3285 (1989).

    PubMed  CAS  Google Scholar 

  3. C. Méne, and S.P. Goff, J. Virol. 63:1558–1568 (1989).

    Google Scholar 

  4. A.G. Szabo, and D.M. Rayner, J. Am. Chem. Soc. 102:554–563 (1980).

    Article  CAS  Google Scholar 

  5. Y. Mély, H. De Rocquigny, E. Piémont, H. Déméné, N. Jullian, M.C. Fournié-Zaluski, B.P. Roques and D. Gérard, Biochim. Biophys. Acta 1161:6–18 (1993).

    Article  PubMed  Google Scholar 

  6. N. Morellet, N. Jullian, H. de Rocquigny, B. Maigret, J.L. Darlix, and B.P. Roques, Embo J. 11:3059–3065 (1992).

    PubMed  CAS  Google Scholar 

  7. Y. Mély, E. Piémont, M. Sorinas-Jimeno, D. Gérard, H. De Rocquigny, N. Jullian, N. Morellet and B.P. Roques, Biophys. J. in press (1993).

    Google Scholar 

  8. H. de Rocquigny, C. Gabus, A. Vincent, M.C. Fournié-Zaluski, B.P. Roques and J.L. Darlix, Proc. Natl. Acad. Sci. USA 89:6472–6476 (1992).

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Laboratoire de Biophysique, URA 491 du CNRS, Université Louis Pasteur, 67401, Illkirch Cedex, France

    Yves Mély, Etienne Piémont, Monica Sorinas-Jimeno & Dominique Gerard

  2. Département de Chimie Organique, INSERM U266 - CNRS UA 448, UFR des Sciences Pharmaceutiques et Biologiques, 75270, Paris Cedex 06, France

    Hugues de Rocquigny, Nathalie Jullian, Nelly Morellet & Bernard P. Roques

Authors
  1. Yves Mély
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  2. Etienne Piémont
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  3. Monica Sorinas-Jimeno
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  4. Hugues de Rocquigny
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  5. Nathalie Jullian
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  6. Nelly Morellet
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  7. Bernard P. Roques
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  8. Dominique Gerard
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Editor information

Editors and Affiliations

  1. Stanford University, Stanford, California, USA

    Sebastian Doniach

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© 1994 Springer Science+Business Media New York

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Mély, Y. et al. (1994). Structure and tRNAPhe-Binding Properties of the Zinc Finger Motifs of HIV-1 Nucleocapsid Protein. In: Doniach, S. (eds) Statistical Mechanics, Protein Structure, and Protein Substrate Interactions. NATO ASI Series, vol 325. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1349-4_31

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  • DOI: https://doi.org/10.1007/978-1-4899-1349-4_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1351-7

  • Online ISBN: 978-1-4899-1349-4

  • eBook Packages: Springer Book Archive

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