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Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

  • Book
  • © 1994

Overview

Editors:
  1. Sebastian Doniach

    1. Stanford University, Stanford, USA

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Part of the book series: NATO Science Series B: (NSSB, volume 325)

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-ix
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  2. Protein Folding Intermediates

    1. Pathways and Mechanism of Protein Folding

      • Robert L. Baldwin
      Pages 1-6

    2. The Folding Pathway of Apomyoglobin

      • Patricia A. Jennings, H. Jane Dyson, Peter E. Wright
      Pages 7-18

    3. Circular Dichroism Stopped-Flow Studies of Folding Intermediates

      • Michel E. Goldberg, Alain F. Chaffotte
      Pages 19-29

    4. Native-Like Intermediates in Protein Folding

      • Wolfgang Pfeil
      Pages 31-38

    5. A First-Order Phase Transition Between a Compact Denatured State and a Random Coil State in Staphylococcal Nuclease

      • Apostolos G. Gittis, Wesley E. Stites, Eaton E. Lattman
      Pages 39-47

  4. Basic Interactions

    1. Monte Carlo Simulation of Electrostatic Interactions in Biomolecules

      • Bo Jönsson, Bo Svensson
      Pages 75-85

    2. The Molecular Origin of the Large Entropies of Hydrophobic Hydration

      • Themis Lazaridis, Michael E. Paulaitis
      Pages 87-101

  5. Statistical Mechanical Models and Protein States

    1. Statistical Mechanics of Secondary Structures in Proteins: Characterization of a molten globule—like state

      • J. Bascle, S. Doniach, T. Garel, H. Orland
      Pages 103-108

    2. Hydrophobic Zippers: A Conformational Search Strategy for Proteins

      • Ken A. Dill, Klaus M. Fiebig
      Pages 109-113

    3. Theoretical Perspectives on In Vitro and In Vivo Protein Folding

      • D. Thirumalai
      Pages 115-134

    4. On the Configurations Accessible to Folded and to Denatured Proteins

      • J. C. Smith, P. Calmettes, D. Durand, M. Desmadril, S. Furois-Corbin, G. R. Kneller et al.
      Pages 135-145

  6. Exploring Conformation Space

    1. Experiences with Dihedral Angle Space Monte Carlo Search for Small Protein Structures

      • Natalya A. Kurochkina, Hong Seok Kang, B. Lee
      Pages 147-157

    2. Constrained Langevin Dynamics of Polypeptide Chains

      • Niels Grønbech-Jensen, Sebastian Doniach
      Pages 159-164

    3. Moil: A Molecular Dynamics Program with Emphasis on Conformational Searches and Reaction Path Calculations

      • Ron Elber, Adrian Roitberg, Carlos Simmerling, Robert Goldstein, Gennady Verkhivker, Haiying Li et al.
      Pages 165-191

    4. Flexibility in the Fc Region of Immunoglobulin G

      • R. Oomen, M. S. Chappel, M. Klein
      Pages 193-195
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Keywords

About this book

A number of factors have come together in the last couple of decades to define the emerging interdisciplinary field of structural molecular biology. First, there has been the considerable growth in our ability to obtain atomic-resolution structural data for biological molecules in general, and proteins in particular. This is a result of advances in technique, both in x-ray crystallography, driven by the development of electronic detectors and of synchrotron radiation x-ray sources, and by the development ofNMR techniques which allow for inference of a three-dimensional structure of a protein in solution. Second, there has been the enormous development of techniques in DNA engineering which makes it possible to isolate and clone specific molecules of interest in sufficient quantities to enable structural measurements. In addition, the ability to mutate a given amino acid sequence at will has led to a new branch of biochemistry in which quantitative measurements can be made assessing the influence of a given amino acid on the function of a biological molecule. A third factor, resulting from the exponential increase in computing power available to researchers, has been the emergence of a growing body of people who can take the structural data and use it to build atomic-scale models of biomolecules in order to try and simulate their motions in an aqueous environment, thus helping to provide answers to one of the most basic questions of molecular biology: the relation of structure to function.

Editors and Affiliations

  • Stanford University, Stanford, USA

    Sebastian Doniach

Bibliographic Information

  • Book Title: Statistical Mechanics, Protein Structure, and Protein Substrate Interactions

  • Editors: Sebastian Doniach

  • Series Title: NATO Science Series B:

  • DOI: https://doi.org/10.1007/978-1-4899-1349-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1994

  • Hardcover ISBN: 978-0-306-44728-0Published: 30 September 1994

  • Softcover ISBN: 978-1-4899-1351-7Published: 19 June 2013

  • eBook ISBN: 978-1-4899-1349-4Published: 22 November 2013

  • Series ISSN: 0258-1221

  • Edition Number: 1

  • Number of Pages: IX, 406

  • Topics: Animal Physiology, Biological and Medical Physics, Biophysics

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