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Benzomorphans

  • Chapter
Opioid Analgesics

Abstract

Simplification of the morphine structure to give series of morphinan congeners (Chapter 3) demonstrated not only that strong analgesics with activities greater than that of morphine could be developed, but that accentuation of other opiate properties (e.g., cough suppression) could be selected. Further simplification to a bridged naphthalene, by exclusion of the morphinan D-ring, rather than a phenanthrene structure, was, therefore, an obvious progression.

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  1. University of Bath, Bath, UK

    Alan F. Casy & Robert T. Parfitt

  2. Canberra College of Advanced Education, Belconnen, ACT, Australia

    Robert T. Parfitt

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Casy, A.F., Parfitt, R.T. (1986). Benzomorphans. In: Opioid Analgesics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0585-7_4

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