Benzomorphans

  • Alan F. Casy
  • Robert T. Parfitt

Abstract

Simplification of the morphine structure to give series of morphinan congeners (Chapter 3) demonstrated not only that strong analgesics with activities greater than that of morphine could be developed, but that accentuation of other opiate properties (e.g., cough suppression) could be selected. Further simplification to a bridged naphthalene, by exclusion of the morphinan D-ring, rather than a phenanthrene structure, was, therefore, an obvious progression.

Keywords

Analgesic Activity Absolute Configuration Antagonist Activity Thionyl Chloride Quaternary Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Alan F. Casy
    • 1
  • Robert T. Parfitt
    • 1
    • 2
  1. 1.University of BathBathUK
  2. 2.Canberra College of Advanced EducationBelconnenAustralia

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