Opioid Analgesics

Chemistry and Receptors

  • Alan F. Casy
  • Robert T. Parfitt

Table of contents

  1. Front Matter
    Pages i-xv
  2. Alan F. Casy, Robert T. Parfitt
    Pages 1-8
  3. Alan F. Casy, Robert T. Parfitt
    Pages 9-104
  4. Alan F. Casy, Robert T. Parfitt
    Pages 105-151
  5. Alan F. Casy, Robert T. Parfitt
    Pages 153-214
  6. Alan F. Casy, Robert T. Parfitt
    Pages 215-227
  7. Alan F. Casy, Robert T. Parfitt
    Pages 229-249
  8. Alan F. Casy, Robert T. Parfitt
    Pages 287-301
  9. Alan F. Casy, Robert T. Parfitt
    Pages 303-332
  10. Alan F. Casy, Robert T. Parfitt
    Pages 333-384
  11. Alan F. Casy, Robert T. Parfitt
    Pages 385-403
  12. Alan F. Casy, Robert T. Parfitt
    Pages 405-444
  13. Alan F. Casy, Robert T. Parfitt
    Pages 445-502
  14. Back Matter
    Pages 503-518

About this book

Introduction

The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal­ gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono­ logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.

Keywords

analgesics biochemistry chemistry opioid pharmacology receptor research

Authors and affiliations

  • Alan F. Casy
    • 1
  • Robert T. Parfitt
    • 1
    • 2
  1. 1.University of BathBathUK
  2. 2.Canberra College of Advanced EducationBelconnenAustralia

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4899-0585-7
  • Copyright Information Springer-Verlag US 1986
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4899-0587-1
  • Online ISBN 978-1-4899-0585-7
  • About this book
Industry Sectors
Chemical Manufacturing
Biotechnology
Consumer Packaged Goods
Pharma