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Genetic Regulation of Apoptosis in the Mouse Thymus

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation VI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 406))

Abstract

Recently, it has become clear that apoptosis, a form of programmed cell death, plays an active role in the maintenance of homeostasis of cells as well in the morphological sculpting of organisms during development1,2. Some of the best characterized examples of apoptosis may be found in the immune system. For example, apoptosis is the mechanism used during negative selection in the thymus to remove self-reactive T cells3–5. Thymic T cells also are quite susceptible to induction of apoptosis by either glucocorticoids or ionizing radiation6,7. Additionally, more recent data indicate that peripheral lymphocytes undergo apoptosis following a variety of different stimuli and, in many instances, cell death in activated peripheral T cells may be traced to Fas/FasL interactions8–10.

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Authors and Affiliations

  1. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, 01003, USA

    Barbara A. Osborne, Sallie W. Smith & Grant Morgan

  2. Program in Molecular & Cellular Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA

    Barbara A. Osborne, Kelly A. McLaughlin & Lisa Grimm

  3. Department of Biology, Amherst College, Amherst, Massachusetts, 01002, USA

    Richard A. Goldsby

Authors
  1. Barbara A. Osborne
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  2. Sallie W. Smith
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  3. Kelly A. McLaughlin
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  4. Lisa Grimm
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  5. Grant Morgan
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  6. Richard A. Goldsby
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Correspondence to Barbara A. Osborne .

Editor information

Editors and Affiliations

  1. University of California, Irvine, Irvine, California, USA

    Sudhir Gupta

  2. University of Colorado Health Sciences Center, Denver, Colorado, USA

    J. John Cohen

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© 1996 Springer Science+Business Media New York

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Osborne, B.A., Smith, S.W., McLaughlin, K.A., Grimm, L., Morgan, G., Goldsby, R.A. (1996). Genetic Regulation of Apoptosis in the Mouse Thymus. In: Gupta, S., Cohen, J.J. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation VI. Advances in Experimental Medicine and Biology, vol 406. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0274-0_21

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  • DOI: https://doi.org/10.1007/978-1-4899-0274-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0276-4

  • Online ISBN: 978-1-4899-0274-0

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