Overview
- Editors:
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Sudhir Gupta
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University of California, Irvine, Irvine, USA
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J. John Cohen
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University of Colorado Health Sciences Center, Denver, USA
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Table of contents (25 chapters)
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Cell Cycle and Signaling Pathways in Apoptosis
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- Robert A. Schlegel, Melissa Callahan, Stephen Krahling, Deepti Pradhan, Patrick Williamson
Pages 21-28
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- Seamus J. Martin, Gustavo P. Amarante-Mendes, Douglas R. Green
Pages 29-37
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- Steven J. Chmura, Edwardine Nodzenski, Mary A. Crane, Subbulakshmi Virudachalam, Dennis E. Hallahan, Ralph R. Weichselbaum et al.
Pages 39-55
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- N. Jan Chalupny, Liqing Zhu, Xue-zhong Yu, Claudio Anasetti
Pages 57-67
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- Jonathan W. Uhr, Radu Marches, Emil Racila, Thomas F. Tucker, Robert Hsueh, Nancy E. Street et al.
Pages 69-74
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Apoptosis-Regulating Genes
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- Gabriel Nuñez, Ramon Merino, Philip L. Simonian, Didier A. M. Grillot
Pages 75-82
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- N. J. McCarthy, S. A. Hazlewood, D. S. Huen, A. B. Rickinson, G. T. Williams
Pages 83-97
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- John C. Reed, Hongbin Zha, Christine Aime-Sempe, Shinichi Takayama, Hong-Gang Wang
Pages 99-112
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- Giovina Ruberti, Isabella Cascino, Giuliana Papoff, Adriana Eramo
Pages 125-134
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Apoptosis in B Cells
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- John Gordon, Christopher D. Gregory, Gillian Grafton, John D. Pound
Pages 139-144
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- Robert F. Ashman, David Peckham, Laura L. Stunz
Pages 145-154
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- Karen A. Jacobsen, Eustache Paramithiotis, Don L. Ewert, Michael J. H. Ratcliffe
Pages 155-165
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- Philip Kuo, Daniel Michael, Boaz Tadmor, Betty Diamond
Pages 167-176
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- Thomas L. Rothstein, Linda C. Foote, Thomas J. Schneider, Gavin M. Fischer, Bruce A. Jacobson, David H. Lynch et al.
Pages 177-189
About this book
Since programmed cell death was first described in insects in 1964 and apoptosis was described in 1972, rapid progress has been made in understanding the basic mechanisms and genes regulating programmed cell death and apoptosis. In addition, defects in various genes regulating programmed cell death have been delineated in several experimental models of human diseases. This volume surveys various aspects of these rapidly developing areas of research in programmed cell death/apoptosis. This volume should be of interest to basic immunologists and molecular biologists. The volume begins with a historical perspective of cell death. The remainder of the volume is divided into four different parts. Part I deals with the signaling pathways in apoptosis, including cell cycle control of apoptosis, role of ceramide in apoptosis, role of antibody signaling, and biochemical regulation of apoptosis. The mechanisms for recognition of apoptotic lymphocytes by macrophages are also reviewed. Part II examines the role of various genes that regulate apoptosis, including the role ofFas, FasL, and other TNF family members in apoptosis and homeostatic regulation of immune response. Recently described splice variants and their influence on apoptosis are also reviewed, and the role of the members of the Bcl-2 family in apoptosis is discussed in detail. Part III reviews various aspects of apoptosis in B lymphocytes, including mechanisms that regulate apoptosis/survival of B lymphocytes and the regulation of Fas-mediated apoptosis in B lymphocytes.
Reviews
`This book is a valuable addition to the literature.'
Quarterly Review of Biology, March 1998
Editors and Affiliations
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University of California, Irvine, Irvine, USA
Sudhir Gupta
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University of Colorado Health Sciences Center, Denver, USA
J. John Cohen