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Lymphocyte Apoptosis in HIV Infection

  • Chapter
Immunology of HIV Infection

Abstract

Human immunodeficiency virus (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). Our understanding of the complexities of pathogenic mechanisms of HIV disease is still evolving; however, the mechanism whereby HIV-1 infection leads to profound depletion of CD4 T cells remains one of the central unsolved problems in AIDS research. In the past several years, there has been a dichotomy between virological and immunological viewpoints in understanding HIV-mediated cytopathicity, the former emphasizing killing of infected CD4 cells by HIV and the latter emphasizing indirect mechanisms wherein HIV or its soluble component(s) alter CD4 T-cell function and induce susceptibility to apoptosis.

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  1. Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York, 11030, USA

    Naoki Oyaizu & Savita Pahwa

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  1. Naoki Oyaizu
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  1. University of California, Irvine, California, USA

    Sudhir Gupta M.D., Ph.D.

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Oyaizu, N., Pahwa, S. (1996). Lymphocyte Apoptosis in HIV Infection. In: Gupta, S. (eds) Immunology of HIV Infection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0191-0_7

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