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Autoimmunity in HIV

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Immunology of HIV Infection

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Abstract

Autoimmunity has been referred to as a dyslexic process of self-recognition (Katz, 1993), that is, a disturbance in the ability to communicate such that the immune system is unable to properly “read” the markers on partner cells. Such communication is essential for immune reactions against foreign antigens to occur in a normal manner as well as for tolerance to occur following self-recognition. The role of viruses in the etiopathogenesis of human autoimmune disease has long been suspected but as yet unproven. However, recent evidence suggests that viruses may be involved in the pathogenesis of Sjogren’s syndrome (Talal, 1991). If viruses do in fact play a role in inducing autoimmune disease, the mechanism(s) involved remain to be elucidated. In particular, it is not clear whether virus-induced autoimmunity is the result of a normal antiviral immune response that subsequently cross-reacts with self-antigens or whether viruses actually induce abnormal communication within the immune system such that self-antigens are misread as foreign.

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References

  • Argov, S., Schattner, A., Burstein, R., Handzel, Z. T., Shoenfeld, Y., and Bentwich, Z., 1991, Autoantibodies in male homosexuals and HIV infection, Immunol. Lett. 30:31–36.

    Article  PubMed  CAS  Google Scholar 

  • Atlan, H., Gersten, M. J., Salk, P. L., and Salk, J., 1994, Mechanisms of autoimmunity and AIDS: Prospects for therapeutic intervention, Res. Immunol. 145:165–183.

    Article  PubMed  CAS  Google Scholar 

  • Berman, A., Espinoza, L. R., Diaz, J. D., Aguilar, J. L., Rolando, T., Vasey, F. B., Germain, B. R., and Lockey, R. P., 1988, Rheumatic manifestation of human immunodeficiency virus infection, Am. J. Med. 85:59–64.

    Article  PubMed  CAS  Google Scholar 

  • Bermas, B. L., Petri, M., Goldman, D., Mittleman, B., Miller, M., Stocks, N., Via, C. S., and Shearer, G. M., 1994, T helper cell dysfunction in systemic lupus erythematosus (SLE): Relation to disease activity, J. Clin. Immunol. 14:169–177.

    Article  PubMed  CAS  Google Scholar 

  • Callahan, L. N., Roderiquez, G., Mallinson, M., and Norcross, M. A., 1992, Analysis of HIV-induced autoantibodies to cryptic epitopes on human CD4, J. Immunol. 149:2194–2202.

    PubMed  CAS  Google Scholar 

  • Canoso, R. T., and Zon, L. L., 1987, Anticardiolipin antibodies associated with HTLV-III infection, Br. J. Haematol. 65:495–498.

    Article  PubMed  CAS  Google Scholar 

  • Clerici, M., and Shearer, G. M., 1993, A Thl→Th2 switch is a critical step in the etiology of HIV infection, Immunol Today 14:107–111.

    Article  PubMed  CAS  Google Scholar 

  • Clerici, M., Stocks, N. I., Zajac, R. A., Boswell, R. N., Lucey, D. R., Via, C. S., and Shearer, G. M., 1989, Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients: Independence of CD4+ cell numbers and clinical staging, J. Clin. Invest. 84:1892–1899.

    Article  PubMed  CAS  Google Scholar 

  • Clerici, M., Hakim, F. T., Venzon, D. J., Blatt, S., Hendrix, C. W., Shearer, G. M., and Wynn, T. A., 1993, Changes in interleukin-2 and interleukin-4 production in asymptomatic, human immunodeficiency virus-seropositive individuals, J. Clin. Invest. 91:759–765.

    Article  PubMed  CAS  Google Scholar 

  • Clerici, M., Wynn, T. A., Berzofsky, J. A., Blatt, S. P., Hendrix, C. W., Sher, A., Coffman, R. L., and Shearer, G. M., 1994, Role of interleukin-10 in T helper cell dysfunction in asymptomatic individuals infected with the human immunodeficiency virus, J. Clin. Invest. 93:768–775.

    Article  PubMed  CAS  Google Scholar 

  • Cohen, A. J., Philips, T. M., and Kressler, C. M., 1986, Circulating coagulation inhibitors in the acquired immunodeficiency syndrome, Ann. Intern. Med. 104:175–180.

    Article  PubMed  CAS  Google Scholar 

  • Dalgleish, A. G., 1993, What is the role of autoimmunity in AIDS? Autoimmunity 15:237–244.

    Article  PubMed  CAS  Google Scholar 

  • Daraco, J. C., Gutierrez-Cebollada, J., Yazbeck, H., Berges, A., and Rubies-Prat, J., 1992, Anticardiolipin antibodies and acquired immunodeficiency syndrome: Prognostic marker or association with HIV infection? Infection 20;140–142.

    Article  Google Scholar 

  • Douvas, A., and Takehana, Y., 1994, Cross-reactivity between autoimmune anti-U1 sn RNP antibodies and neutralizing epitopes of HIV-1 gp 120/41, AIDS Res. Hum. Retrovir. 10:253–262.

    Article  PubMed  CAS  Google Scholar 

  • Eales, L., and Parkin, J. M., 1988, Current concepts in the immunopathogenesis of AIDS and HIV infection, Br. Med. Bull. 44:38–55.

    PubMed  CAS  Google Scholar 

  • Eddleston, M., de La Torre, J. C., Xu, J. Y., Dorfman, N., Notkins, A., Zolla-Pazner, S., and Oldstone, M. B., 1993, Molecular mimicry accompanying HIV-1 infection: human monoclonal antibodies that bind to gp 41 and to astrocytes, AIDS Res. Hum. Retrovir. 9:939–944.

    Article  PubMed  CAS  Google Scholar 

  • Edelman, A. S., and Zolla-Pazner, S., 1989, AIDS: A syndrome of immune dysregulation, dysfunction and deficiency, FASEB J. 3:22–30.

    PubMed  CAS  Google Scholar 

  • Euler, H. H., Kern, P., Loffler, H., and Dietrich, H., 1985, Precipitable immune complexes in healthy homosexual men, acquired immune deficiency syndrome and the related lymphadenopathy syndrome, Clin. Exp. Immunol. 59:267–275.

    PubMed  CAS  Google Scholar 

  • Golding, H., Robey, R A., Gates, F. T., Linder, W., Beining, P. R., Hoffman, T., and Golding, B., 1988, Identification of homologous regions in human immunodeficiency virus 1 gp41 and human MHC class II beta 1 domain. I. Monoclonal antibodies against the gp 41-derived peptide and patient’s sera react with native HLA class II antigens, suggesting a role for autoimmunity in the pathogenesis of acquired immune deficiency syndrome, J. Exp. Med. 167:914–923.

    Article  PubMed  CAS  Google Scholar 

  • Gupta, S., and Licorish, K., 1992, Circulating immune complex in AIDS [letter], N. Engl. J. Med. 310:1530–1531.

    Google Scholar 

  • Karpatkin, S., and Nardi, M., 1992, Autoimmune anti-HIV-1 gp 120 antibody with antiidiotype-like activity in sera and immune complex of HIV-1 related immunologie thrombocytopenia, J. Clin. Invest. 89:356–364.

    Article  PubMed  CAS  Google Scholar 

  • Katz, D. H., 1993, AIDS: Primarily a viral or autoimmune disease? AIDS Res. 9:489–493.

    CAS  Google Scholar 

  • Kion, T. A., and Hoffmann, G. W., 1991, Anti-HIV and anti-anti-MHC antibodies in alloimmune and autoimmune mice, Science 253:1138–1140.

    Article  PubMed  CAS  Google Scholar 

  • Kopelman, R. A., and Zolla-Pazner, S., 1988, Association of human immunodeficiency virus infection and autoimmune phenomena, Am. J. Med. 84:82–88.

    Article  PubMed  CAS  Google Scholar 

  • Kumar, M., Resnick, L., Loewenstein, D. A., Berger, J., and Eisdorfer, C., 1989, Brain-reactive antibodies and the AIDS dementia complex, J. Acq. Immune Defic. Syndr. 2:469–471.

    CAS  Google Scholar 

  • Lake-Bakaar, G., Quadros, E., Beidas, S., Eisakr, M., Tom, W., Wilson, D. E., Dincsoy, H. P., Cohen, P., and Straws, E. W., 1988, Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS), Ann. Intern. Med. 109:502–504.

    Article  PubMed  CAS  Google Scholar 

  • Madaio, M. P., Schattner, A., Schattner, M., and Schwartz, R. S., 1986, Lupus serum and normal human serum contain anti-DNA antibodies with the same idiotypic marker, J. Immunol 137:2535–2540.

    PubMed  CAS  Google Scholar 

  • Mathiesen, T., Sonnerborg, A. S., and Wahren, B., 1989, Detection of antibodies against myelin basic protein and increased level of HIV IgG antibodies and HIV antigen after stabilization of immune complexes in sera and CSF of HIV infected patients, Viral Immunol. 2:1–9.

    Article  PubMed  CAS  Google Scholar 

  • Muller, C., Kukel, S., and Bauer, R., 1993, Relationship of antibodies against CD4+ T cells in HIV-infected patients to markers of activation and progression: Autoantibodies are closely associated with CD4 cell depletion, Immunology 79:248–254.

    PubMed  CAS  Google Scholar 

  • Muller, C., Kukel, S., and Bauer, R., 1994, Antibodies against CD4+ lymphocytes in plasma of HIV-infected patients are related to CD4 cell depletion in vivo, Immunol. Lett. 41:163–167.

    Article  PubMed  CAS  Google Scholar 

  • Pruzanski, W., Jacobs, J., and Lome, P., 1984, Lymphocytotoxic antibodies against peripheral blood B and T lymphocytes in homosexuals with AIDS and ARC., AIDS Res. Hum. Retrovir. 1:211–220.

    CAS  Google Scholar 

  • Reither, W. E., Blalock, J. E., and Brunck, T. K., 1986, Sequence homology between acquired immunodeficiency syndrome virus envelope protein and interleukin 2, Proc. Natl. Acad. Sci. USA 83:9188–9192.

    Article  Google Scholar 

  • Rus, V., Svetic, A., Nguyen, P. H., Gause, W. C., and Via, C. S., 1995, Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease: Regulatory role of donor CD8+ T cells, J. Immunol. 155:2396–2406.

    PubMed  CAS  Google Scholar 

  • Savige, J. A., Chang, L., Horns, S., and Crowe, S. M., 1994, Anti-nuclear anti-neutrophil cytoplasmic and anti-glomerular basement membrane antibodies in HIV-infected individuals, Autoimmunity 18:205–211.

    Article  PubMed  CAS  Google Scholar 

  • Schattner, A., 1987, The origin of autoantibodies, Immunol. Lett. 14:143–153.

    Article  PubMed  CAS  Google Scholar 

  • Schattner, A., and Bentwich, Z., 1993, Autoimmunity in human immunodeficiency virus infection, Clin. Aspects Autoimmun. 5:19–27.

    Google Scholar 

  • Solder, B., Marschang, P., Wachter, H., Dierich, M. P., Nayyar, S., Lewin, I. V., and Stanworth, D. R., 1990, Antiviral antibodies in HIV (HTLV-III) infection possess autoantibody activity against CHI domain determinant in human Ig4: Possible immunological consequences, Immunol. Lett. 23:9–20.

    Article  Google Scholar 

  • Solinger, A. M., Adams, L. E., Freidman-Kien, A. E., and Hess, E. V., 1988, Acquired immune deficiency syndrome (AIDS) and autoimmunity—Mutually exclusive entities? J. Clin. Invest. 8:32–42.

    CAS  Google Scholar 

  • Spehar, T., and Strand, M., 1994, Cross-reactivity of anti-human immunodeficiency virus type 1 gp41 antibodies with human astrocytes and astrocytoma cell lines, J. Virol. 68:6262–6269.

    PubMed  CAS  Google Scholar 

  • Stimmler, M. M., Quismorio, F. P., McGehee, F. P., Boylent, T., and Sharma, O. P., 1989, Anticardiolipin antibodies in acquired immunodeficiency syndrome, Arch. Intern. Med. 149:1833–1835.

    Article  PubMed  CAS  Google Scholar 

  • Susal, C., Daniel, V., Ober, H. H., Terness, P., Huth-Kuhne, A., Zimmerman, R., and Opelz, A., 1992, Striking inverse association of IgG-anti-Fabγ antibodies and CD4 cell counts in patients with acquired immunodeficiency syndrome (AIDS)/AIDS related complex, Blood 79:954–957.

    PubMed  CAS  Google Scholar 

  • Susal, C., Kropelin, M., Daniel, V., and Opelz, A., 1993, Molecular mimicry between HIV-1 and antigen receptor molecules: A clue to the pathogenesis of AIS, Vox Sang. 65:10–17.

    Article  PubMed  CAS  Google Scholar 

  • Talal, N., 1991, Aids and Sjogren’s syndrome, Bull. Rheum. Dis. 40:6–8.

    PubMed  CAS  Google Scholar 

  • Talal, N., Dauphinee, M. J., Dang, H., Alexander, S. S., Hart, D. J., Garry, R. F., 1990a, Detection of serum antibodies to retroviral protein in patients with primary Sjogren’s syndrome (autoimmune exocrinopathy), Arthritis Rheum. 33:774–781.

    Article  PubMed  CAS  Google Scholar 

  • Talal, N., Garry, R. F., Schur, P. H., Alexander, S., Dauphinee, M. J., Livas, J. H., Ballester, A., Takei, M., and Dang, H., 1990b, A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus, J. Clin. Invest. 85:1866–1871.

    Article  PubMed  CAS  Google Scholar 

  • Talal, N., Flescher, E., and Dang, H., 1992, Are endogenous retroviruses involved in human autoimmune disease? J. Autoimmun. 5(Suppl A):61–66.

    Article  PubMed  Google Scholar 

  • Thiriart, C., Goudsmit, J., Schellekens, P., Barin, R., Zagury, D., de Wilde, M., and Bruck, C., 1988, Antibodies to soluble CD4 in HIV-1 infected individuals, AIDS 2:345–350.

    Article  PubMed  CAS  Google Scholar 

  • Vega, M. A., Guiso, R., and Smith, T. R., 1990, Autoimmune response in AIDS [letter], Nature 345:26.

    Article  PubMed  CAS  Google Scholar 

  • Via, C. S., and Shearer, G. M., 1988a, Functional heterogeneity of L3T4+ T cells in MRL-lpr/lpr mice: L3T4+ T cells suppress major histocompatibility complex-self-restricted L3T4+ T helper cell function in association with autoimmunity, J. Exp. Med. 168:2165–2181.

    Article  PubMed  CAS  Google Scholar 

  • Via, C. S., and Shearer, G. M., 1988b, T-cell interactions in autoimmunity—Insights from a murine model of graft-versus-host disease, Immunol. Today 9:207–212.

    Article  PubMed  CAS  Google Scholar 

  • Via, C. S., Morse, H. C., III, and Shearer, G. M., 1990, Altered immunoregulation and autoimmune aspects of HIV infection: Relevant murine models, Immunol. Today 11:250–255.

    Article  PubMed  CAS  Google Scholar 

  • Via, C. S., Tsokos, G. C., Bermas, B. L., Clerici, M., and Shearer, G. M., 1993, T cell-antigen-presenting cell interactions in human systemic lupus erythematosus, J. Immunol. 151:3914–3922.

    PubMed  CAS  Google Scholar 

  • Yarchoan, R., Redfield, R. R., and Broder, S., 1986, Mechanisms of B cell activation in patients with acquired immunodeficiency syndrome and related disorders, J. Clin. Invest. 78:439–447.

    Article  PubMed  CAS  Google Scholar 

  • Yu, J. R., Lennett, E. T., and Karpatkin, S., 1986, Anti-F(ab’) antibodies in thrombocytopenic patients at risk for acquired immunodeficiency syndrome, J. Clin. Invest. 77:1756–1761.

    Article  PubMed  CAS  Google Scholar 

  • Zagury, J. R., Cantalloube, H., Bernard, J., Bizzini, B., Mornon, J. P., and Zagury, D., 1992, A striking identity between HIV-1 envelope glycoprotein gp120 and its CD4 receptor, Lancet 340:483–484.

    Article  PubMed  CAS  Google Scholar 

  • Zagury, J. R., Bernard, J., Achour, A., Astgen, A., Lachgar, A., Fall, L., Carelli, C., Issing, W., Mbika, J. P., Cantalloube, H., Picard, O., Gourbil, A., Guignon, J. M., Cozette, J., Paure, J. P., Biou, D., Carlotti, M., Callebaut, I., Mornon, J. P., Burny, A., Feldman, M., Bizzini, B., and Zagury, D., 1993, HIV-1 induced immune suppression may result from autoimmune disorders including anti-SLWDQ autoantibodies, Biomed. Pharmacother. 47:93–99.

    Article  PubMed  CAS  Google Scholar 

  • Ziegler, J. L., and Stites, D. P., 1986, Hypothesis: AIDS is an autoimmune disease directed at the immune system and triggered by a lymphotropic retrovirus, Clin. Immunol. Immunopathol. 41:305–313.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Research Service, Baltimore VA Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Charles S. Via

  2. Division of Infectious Diseases, University of Maryland School of Medicine, Baltimore, Maryland, 21201, USA

    Arif R. Sarwari

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  1. Charles S. Via
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  1. University of California, Irvine, California, USA

    Sudhir Gupta M.D., Ph.D.

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Via, C.S., Sarwari, A.R. (1996). Autoimmunity in HIV. In: Gupta, S. (eds) Immunology of HIV Infection. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0191-0_13

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  • DOI: https://doi.org/10.1007/978-1-4899-0191-0_13

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