Eledoisin and Ceruletide, Two Naturally Occurring Peptide Drugs of Nonmammalian Origin

  • Roberto de Castiglione
Part of the NATO ASI Series book series (NSSA, volume 125)


Poor absorption and metabolic instability usually make the parenteral route of administration the sole practical one for peptide drugs. Restricted permeability of the blood-brain barrier to peptides may constitute another drawback. The availability of suitable delivery systems could possibly extend the field of application of these drugs. On the other hand, technical problems and uncertain forecast of return of investment often actually limit the studies in this area. This was also the case with eledoisin and ceruletide, two naturally occurring peptide drugs developed in our laboratories as a result of a long and continuous collaboration with Prof. V. Erspamer in the field of biologically active peptides of nonmammalian origin.


Paralytic Ileus Peptide Drug Keratoconjunctivitis Sicca Nasal Absorption Amphibian Skin 
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  1. Agosti, A. and Bertaccini, G., 1969, Nasal absorption of caerulein, The Lancet, March, 15: 580.CrossRefGoogle Scholar
  2. Agosti, A., Biasoli, S., and Naranjo, G., 1969, Azione della ceruleina sulla secrezione gastrica umana, Soc. Ital. Biol. Sperim., 45: 778.Google Scholar
  3. Anastasi, A., and Erspamer V., 1963, The isolation and amino acid sequence of eledoisin, the active endecapeptide of the posterior salivary glands of Eledone, Arch. Biochem. Biophys., 101: 56.PubMedCrossRefGoogle Scholar
  4. Anastasi, A., Erspamer, V., and Endean, R., 1967, Isolation and structure of caerulein, an active decapeptide from the skin of Hyla caerulea, Experientia, 23: 699.PubMedCrossRefGoogle Scholar
  5. Basso, N., Bagarani, M., Materia, A., Gizzonio, D., De Paolis, C., Praga, C., and Speranza, V., 1985, Effect of caerulein in patients with biliary colic pain, Gastroenterology, 89: 605.PubMedGoogle Scholar
  6. Bernardi, L., Bosisio, G., Chillemi, F., de Caro, G., de Castiglione, R., Erspamer, V., Glässer, A., and Goffredo, O., 1964, Synthetic peptides related to eledoisin, Experientia, 20: 306.PubMedCrossRefGoogle Scholar
  7. Bernardi, L., de Castiglione, R., Fregnan, G.B., and Glässer, A.H., 1967, An experimental approach to long-lasting hypotensive eledoisin-like peptides, J.Pharm.Pharmac., 19: 95.CrossRefGoogle Scholar
  8. Bertaccini, G., 1976, Active polypeptides of nonmammalian origin, Pharmacol.Rev., 28: 127.PubMedGoogle Scholar
  9. Bietti, G.B., de Caro, G., Pecori Giraldi, J., and Romani, E., 1976, Besondere Indikationen für die Anwendung weicher Kontactlinsen als Augentropfenreservoir (Drug release system), Klin.Mbl.Augenheilk., 168: 33.PubMedGoogle Scholar
  10. Castellino, S., de Castiglione, R., Galantino, M., Forino, R., Licci, S., and Perseo, G., Mutagenic contaminants in synthetic peptides obtained by an azide coupling, Manuscript in preparation.Google Scholar
  11. de Castiglione, R., 1983, Exploitation and exploration of ceruletide and eledoisin, two peptides of nonmammalian origin, Biopolymers, 22: 507.PubMedCrossRefGoogle Scholar
  12. de Castiglione, R., Faoro, F., Piani, S., Perseo, G., Santangelo, F., Arcari, G., di Salle, E., and Rossi, A., 1981, Synthesis and biological activity of dermorphin analogues, Poster presented at the “7th American Peptide Symposium”, Abstract p. 53.Google Scholar
  13. de Castiglione, R., and Rossi, A., 1985, Amphibian skin peptides with analgesic activity, in “8th International Symposium on Medicinal Chemistry, Vol. 1”, R. Dahlbom and J.L.G. Nilsson, eds., Swedish Pharmaceutical Press, Stockholm, pp. 147.Google Scholar
  14. Deschodt-Lanckman, M., Bui, N.D., Noyer, M., and Christophe, J., 1981, Degradation of cholecystokinin-like peptides by a crude rat brain synaptosomal fraction: a study by high pressure liquid chromatography, Regul. Peptides, 2: 15.CrossRefGoogle Scholar
  15. di Salle, E., and Ragazzi, P., 1976, Evidenza dellfassorbimento della ceruleina dal tratto gastroenterico mediante valutazione dell’attività colecistochinetica nella cavia, Communication at the “XVIII Congresso Nazionale della Società Italiana di Farmacologia”, Abstract p. 105.Google Scholar
  16. Erspamer, V., and Anastasi, A., 1962, Structure and pharmacological action of eledoisin, the active endecapeptide of the posterior salivary glands of Eledone, Experientia, 18: 58.PubMedCrossRefGoogle Scholar
  17. Erspamer, V., and Melchiorri, P., 1973, Active polypeptides of the amphibian skin and their synthetic analogues, Pure Appl. Chem., 35: 463.CrossRefGoogle Scholar
  18. Erspamer, V., and Melchiorri, P., 1983, Actions of amphibian skin peptides on the central nervous system and the anterior pituitary, in “Neuroendocrine Perspectives, Vol. 2”, E.E. Müller and R.M. Mac Leod, eds., Elsevier Publishers B.V.Google Scholar
  19. Erspamer, V., Melchiorri, P., Falconieri Erspamer, G., Montecucchi, P.C., and de Castiglione, R. 1985, Phyllomedusa skin: huge factory of a variety of active peptides, Peptides, 6: suppl. 3, 7.PubMedCrossRefGoogle Scholar
  20. Grossi, E., Vertemati, F., Casiraghi, M.A., Petrillo, M., and Bianchi Porro, G., 1980, Action of caerulein on gastric acid secretion. A comparative study between the rectal and i.m. routes, Il Farmaco-Ed.Pr., 35: 504.Google Scholar
  21. Harman, A.J., 1984, Three tachykinins in mammalian brain, TINS, 7: 57.Google Scholar
  22. Holzer-Petsche, U., Schimek, E., Amann, R., and Lembeck, F., 1985, In vivo and in vitro actions of mammalian tachykinins, Naunyn-Schmiedeberg’s Arch.Pharmacol., 330: 130.CrossRefGoogle Scholar
  23. Impicciatore, M., Maraini, G., and Bertaccini, G., 1973, Action of eledoisin on human lacrimal secretion in normal and pathological conditions, Naunyn-Schmiedeberg’s Arch. Pharmacol., 279: 127.CrossRefGoogle Scholar
  24. Larsson, L.-J., and Rehfeld, J.F., 1977, Evidence for a common evolutionary origin of gastrin and cholecystokinin, Nature, 269: 335.PubMedCrossRefGoogle Scholar
  25. Orlandini, I., and Agosti, A., 1969, Azione colecistocinetica della ceruleina e sua utilizzazione nella metodica colangio-colecistografica, Soc.Ital.Biol.Sperim., 45: 782.Google Scholar
  26. Owais, W.M., Rosicham, J.L., Ronald, R.C., Kleinhofs, A., and Nilan, R.A., 1983, A mutagenic metabolite synthesized by Salmonella typhimurium grown in the presence of azide is azidoalanine, Mutation Res., 118: 229.PubMedCrossRefGoogle Scholar
  27. Pap, A., Berger, Z., and Varrò, V., 1981, Trophic effect of cholecystokinin-octapeptide in man. A new way in the treatment of chronic pancreatis?, Digestion, 21: 163.PubMedCrossRefGoogle Scholar
  28. Sicuteri, F., Franchi, G., and Anselmi, B., 1962, Proprietà farmacologiche e terapeutiche dell’eledoisina nell’uomo, Settimana Med., suppl. 31 dic.:19.Google Scholar
  29. Solomon, T.E., 1983, Structure-activity relationships of cholecystokinin-related peptides, in “2nd Hiroshima Symposium on Gut Peptides and Ulcer”, A. Miyoshi, ed., Biomedical Research Foundation, Tokyo.Google Scholar
  30. Stürmer, E., and Fanchamps, A., 1965, Eledoisin. Chemie, Pharmakologie, klinisch-experimentelle und Vorlaufige therapeutische Erfahrung,, 90: 1012.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Roberto de Castiglione
    • 1
  1. 1.Research & DevelopmentFarmitalia Carlo Erba SpAMilanItaly

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