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Delivery Systems for Peptide Drugs

  • Book
  • © 1986

Overview

Editors:
  1. S. S. Davis

    1. University of Nottingham, Nottingham, England

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    You can also search for this editor in PubMed   Google Scholar

  2. Lisbeth Illum

    1. The Royal Danish School of Pharmacy, Copenhagen, Denmark

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    You can also search for this editor in PubMed   Google Scholar

  3. E. Tomlinson

    1. Ciba-Geigy Pharmaceuticals, Horsham, England

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: NATO Science Series A: (NSSA, volume 125)

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Table of contents (31 chapters)

  1. Front Matter

    Pages i-xii
    Download chapter PDF

  2. Advanced Delivery Systems for Peptides and Proteins — Pharmaceutical Considerations

    • S. S. Davis
    Pages 1-21

  3. Biotechnology and Protein Production

    • Spencer Emtage
    Pages 23-33

  4. Peptide Analysis: Critical Technology for Evaluating Delivery Approaches

    • Larry A. Sternson, Thomas R. Malefyt
    Pages 35-47

  5. Bioreversible Derivatization of Peptides

    • Hans Bundgaard
    Pages 49-68

  6. An Approach to Targeted Therapy: Synthesis and Biological Activity of Hydrophobic and Hydrophilic Enkephalin Analogues

    • José M. García-Antón, Francesca Reig, Gregorio Valencia
    Pages 69-78

  7. Temporal and Pharmacokinetic Aspects in Delivery of Peptides and Proteins

    • Leslie Z. Benet, Robert A. Baughman Jr.
    Pages 79-86

  8. Enzymatic Barriers to Peptide and Protein Absorption and the Use of Penetration Enhancers to Modify Absorption

    • Vincent H. L. Lee
    Pages 87-104

  9. Intracellular Sorting of Proteins

    • Claudia Bibus
    Pages 105-113

  10. Biodegradable Polymers for Sustained Release of Polypeptides

    • F. G. Hutchinson, B. J. A. Furr
    Pages 115-123

  11. Controlled Delivery of Nafarelin, An Agonistic Analogue of LHRH, From Microspheres of Poly (D, L Lactic-Co-Glycolic) Acid

    • Lynda M. Sanders, Karen M. Vitale, Georgia I. Mc Rae, Peter B. Mishky
    Pages 125-137

  12. The Oral Bioavailability of Peptides and Related Drugs

    • M. J. Humphrey
    Pages 139-151

  13. Oral Delivery of Peptide Drugs

    • Karl-Erik Falk, Jan-Erik Löfroth
    Pages 153-158

  14. Drug Delivery of Peptides: The Buccal Route

    • Hans P. Merkle, Reinhold Anders, Jürgen Sandow, Werner Schurr
    Pages 159-175

  15. Enhanced Absorption and Lymphatic Transport of Macromolecules via the Rectal Route

    • Shozo Muranishi, Kanji Takada, Hiroshi Yoshikawa, Masahiro Murakami
    Pages 177-189

  16. Biopharmaceutical Aspects on the Intranasal Administration of Peptides

    • A. S. Harris
    Pages 191-204

  17. Microspheres as a Potential Controlled Release Nasal Drug Delivery System

    • Lisbeth Illum
    Pages 205-210

  18. NazlinR - Transnasal Systemic Delivery of Insulin

    • John P. Longenecker
    Pages 211-220

  19. Nasal Absorption of Enkephalins in Rats

    • Kenneth S. E. Su, Kristina M. Campanale, Laurane G. Mendelsohn, Gail A. Kerchner, Christian L. Gries
    Pages 221-232

  20. Intranasal Delivery of the Peptide, Salmon Calcitonin

    • Musetta Hanson, G. Gazdick, J. Cahill, M. Augustine
    Pages 233-242
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Keywords

About this book

Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.

Editors and Affiliations

  • University of Nottingham, Nottingham, England

    S. S. Davis

  • The Royal Danish School of Pharmacy, Copenhagen, Denmark

    Lisbeth Illum

  • Ciba-Geigy Pharmaceuticals, Horsham, England

    E. Tomlinson

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