Skip to main content

Effects of Changes in Ventilatory Pattern during Altitude Acclimatization

  • Chapter
Control of Breathing and Its Modeling Perspective
  • 120 Accesses

Abstract

The frequent occurrence of periodic breathing (PB) during sleep in sojourners to high altitude has been well documented1–6. PB is thought to be most pronounced during the first few nights at altitude and to diminish over time as the process of acclimatization takes its course4. However, in recent studies conducted at extreme altitudes3, 5, 6, it was found that PB and recurrent apneas persisted even after the subjects tested had been at the altitudes in question for more than 3 weeks. Weil et al.2 reported the common occurrence of “undulating respirations of varying amplitude but without true apnea” in long-term high-altitude residents. Thus, it is probably safe to conclude that there is a tendency for the regularization of breathing pattern with altitude acclimatization, although in some individuals PB is never completely eliminated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Reite, M., D. Jackson, R.L. Cahoon and J.V. Weil. Sleep physiology at high altitude. Electroenceph. clin. Neurophysiol. 32:701–705, 1972.

    Article  Google Scholar 

  2. Weil, J.V., M.H. Kryger and C.H. Scoggin. Sleep and breathing at high altitude. In: Sleep Apnea Syndromes, ed. C. Guilleminault and W.C. Dement, New York: Alan R. Liss, 1978, pp. 119–135.

    Google Scholar 

  3. Lahiri, S., K. Maret and M.G. Sherpa. Dependence of high altitude sleep apnea on ventilatory sensitivity to hypoxia. Respir. Physiol. 52:281–301, 1983.

    Article  PubMed  CAS  Google Scholar 

  4. White, D.P., K. Gleeson, C.K. Pickett, A.M. Rannels, A. Cymerman and J.V. Weil. Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep. J. Appl. Physiol. 63:401–412, 1987.

    PubMed  CAS  Google Scholar 

  5. West, J.B., R.M. Peters Jr., G. Aksnes, K.L. Maret, J.S. Milledge and R.B. Schoene. Nocturnal periodic breathing at altitudes of 6,300 and 8050 m. J. Appl. Physiol. 61:280–287, 1986.

    PubMed  CAS  Google Scholar 

  6. Anholm, J.D., A.C.P. Powles, R. Downey III, CS. Houston, J.R. Sutton, M.H. Bonnet and A. Cymerman. Operation Everest II: Arterial oxygen saturation and sleep at extreme simulated altitude. Am. Rev. Respir. Dis. (in press).

    Google Scholar 

  7. Khoo, M.C.K. A model-based evaluation of the single-breath CO2 ventilatory response test. J. Appl. Physiol. 68:393–399, 1990.

    PubMed  CAS  Google Scholar 

  8. Khoo, M.C.K. The noninvasive estimation of cardiopulmonary parameters. Ph.D. Dissertation, Boston, MA, 1981.

    Google Scholar 

  9. McGregor, M., and M. Becklake. The relationship of oxygen cost of breathing to respiratory mechanical work and respiratory force. J. Clin. Invest. 40:971–980, 1961.

    Article  PubMed  CAS  Google Scholar 

  10. Cotes, J.E. Ventilatory capacity at altitude and its relation to mask design. Proc. R. Soc. Lond. [Biol.] 143:32–39, 1954.

    Article  CAS  Google Scholar 

  11. Milic-Emili, J. Work of breathing. In: The Lung: Scientific Foundations, ed. R.G. Crystal, J.B. West et al., pp.1065–1075, Raven Press, New York, 1991.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Khoo, M.C.K. (1992). Effects of Changes in Ventilatory Pattern during Altitude Acclimatization. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_67

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9847-0_67

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9849-4

  • Online ISBN: 978-1-4757-9847-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics