Abstract
Using a set of Monte Carlo simulation models, track structures of 125I Auger electrons generated in liquid water are superimposed on a nucleosome DNA model able to precisely localize energy deposition events on sub-molecular units of the DNA strands. After scoring direct hits taking place during the physical phase (at about 10−15 s) the radiation chemistry of the whole system is simulated between 10−12 and 10−8 s, taking into account all reactions between water radio-chemical species, radicals, sub-molecular units of DNA (Ribose, Adenine, Thymine, Guanine and Cytosine), and scavengers like Tris or Formate ions.
The model’s possibility to distinguish between direct and indirect hits has been utilized to introduce different assumptions for strand break induction by both hit modes. The number of SSB and DSB as well as their local distribution will be given and compared with experimental and theoretical results from the literature.
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Terrissol, M., Pomplun, E. (1994). A Nucleosome Model for the Simulation of DNA Strand Break Experiments. In: Varma, M.N., Chatterjee, A. (eds) Computational Approaches in Molecular Radiation Biology. Basic Life Sciences, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9788-6_17
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DOI: https://doi.org/10.1007/978-1-4757-9788-6_17
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