Abstract
Positron emission tomography (PET) plays an important role in clinical research as well as an ever increasing role in the diagnosis and staging of several disease states. The expansion of PET will demand the production of greater quantities of short-lived radiopharmaceuticals and thus the need for increased isotope production. In order to meet the supply needs of the PET community, new methods must be developed to economically achieve the required quantities of short-lived isotopes using the current in-house isotope production equipment (cyclotrons, accelerators) or low cost, low energy accelerators.
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References
Blessing, G., Coenen, H.H., Franken, K. and Qaim, S.M., 1986, Production of (18F)F2, H18F and 18F-aq using the 20Ne(d,α)18F process, Appl. Radiat, hot. 37: 1135–1139.
Casella, V., Ido, T., Wolf, A.P., Fowler, J.S., MacGregor, R.R. and Ruth, T.J., 1980, Anhydrous F-18 labeled elemental fluorine for radiopharmaceutical preparation, J. Nucl. Med. 21:750–757.
Clark, J.C. and Silvester, D.J., 1966, A cyclotron method for the production of fluorine-18, Int. J. Appl. Radiat, hot. 17: 151–154.
Crouzel, C. and Comar, D., 1978, Production of carrier-free] 8F-hydrofluoric acid, Int. J. Appl. Radiat, hot. 29: 407–408.
Firouzbakht, M.L., Schlyer, D.J., Gatley, S.J. and Wolf, A.P., 1993, A cryogenic solid target for the production of [18F]fluoride from enriched [18O]carbon dioxide, J. Nucl. Med. 34: P69.
Fitscher, J., Beckmann, R., Holm, U. and Neuert, H., 1977, Yield and production of 18F by 3He irradiation of water, Int. J. Appl. Radiat, hot. 28: 781–784.
Gee, A.D. and Gillings, N., 1994, High pressure liquid 18F-fluoride target systems — effect of HPLC water quality on radiochemical yields., J. Lab. Comp. Radiopharm. in press.
Hughey, B.J., Shefer, R.E., Klinkowstein, R.E., Welch, M.J., Dence, CS. and Livini, E., 1992, A novel cryogenic oxygen-18 target for the production of fluorine-18, J. Nucl. Med. 33: 932.
Iwata, R., Ido, T., Brady, F., Takahashi, T. and Ujuie, A., 1987, (18F)Fluoride production with a circulating (18O)water target, Appl Radiat hot 38: 979–984.
Kilbourn, M.R., Hood, J.T. and Welch, M.J., 1984, A simple 18O-water target for 18F production, Int. J. Appl. Radiat, hot. 35: 599–602.
Kilbourn, M.R., Jerabek, P.A. and Welch, M.J., 1985, An improved (18O)water target for [18F]fluoride production, Int. J. Appl. Radiat, hot. 36: 327–328.
Knust, E.J. and Machulla, H.J., 1983, High yield production of 18F in a water target via the 16O(3He,p)18F reaction, Int. J. Appl. Radiat, hot. 34: 1627–1628.
Lindner, L., Sver, T.H., Brinkman, G.A. and Veenboer, J.T., 1973, A dynamic loop-target for the in-cyclotron production of 18F by the 16O(α,d)18F reaction on water, Int. J. Appl. Radiat, hot. 24: 124.
Mulholland, G.K., Hichwa, R.D., Kilbourn, M.R. and Moskwa, J., 1990, A reliable pressurized water target for F-18 production at high beam currents, J Lab Comp Ratiopharm. 26:192–193.
Nickels, R.J., Daube, M.E. and Hutchins, G.D., 1982, Smaller, colder targets, J Lab.Comp. Ratiopharm. 19: 1364–1365.
Nickels, R.J., Daube, M.E. and Ruth, T.J., 1984, An 18O2 target for the prodcution of (18F)F2, Intl. J. Appl. Radiat, hot. 35: 117.
Nozaki, T., Tanaka, Y., Shimamura, A. and Karasawa, T., 1968, The preparation of anhydrous H18F, Int. J. Appl. Radiat, hot. 19: 27–32.
Padgett, H.C., Schmidt, D.G., Luxen, A., Bida, G.T., Satyamurthy, N. and Barrio, J.R., 1989, Computer-controlled radiochemical synthesis: A chemistry process control unit for the automated production of radiochemicals, Appl. Radiat, hot. 40: 433–445.
Ruth, T.J., 1985, The production of 18F-F2 and 15O2 sequentially from the same target chamber, Int. J. Appl. Radiat, hot. 36: 107–110.
Ruth, T.J., Adam, M.J., Burgerjon, J.J., Lenz, J. and Pate, B.D., 1985, A gas target for radionuclide production with 500 MeV protons, Int. J. Appl. Radiat, hot. 36: 931–933.
Ruth, T.J. and Wolf, A.P., 1979, Absolute cross sections for the production of 18F via the 18O(p,n)18F reaction, Radiochimica Acta 26: 21–24.
Sajjad, M., Lambrecht, R.M. and Wolf, A.P., 1986, Cyclotron isotopes and radiopharmaceuticals. XXXVII. Excitation functions for 16O(p,α)13N and 14N(p,pn)13N reactions, Radiochimica Acta 39: 165–168.
Thomas, C.C., Sondel, J.A. and Kerns, R.C., 1965, Production of carrier-free fluorine- 18., Int. J. Appl. Radiat, hot. 16: 71–74.
Wieland, B.W., Alvord, C.W., Bida, G.T., Hendry, G.O. and Morelle, J.-L., 1991, New liquid target systems for the production of [fluorine-18]fluoride ion and [nitrogen-13]ammonium ion with 11 MeV protons, Proceedings 4th Workshop on Targetry and Target Chemistry.
Wieland, D.M. and Wolf, A.P., 1983, Large-scale production and recovery of aqueous (F-18)fluoride using proton bombardment of a small-volume (O-18)water target, J. Nucl. Med. 24: 122.
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VanBrocklin, H.F., Padgett, H.C., Alvord, C.W., Schmidt, D.G., Bida, G.T. (1995). High Pressure H2 18O Target for the Production of [18F]Fluoride Ion. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_37
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DOI: https://doi.org/10.1007/978-1-4757-9670-4_37
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