Abstract
Proton magnetic resonance imaging (MRI) is a well established clinical modality, which provides excellent anatomical definition. The judicious use of magnetic resonance (MR) contrast agents enhances anatomical definition and novel agents with enhanced specificity are being developed. Currently, there is a major thrust to achieve functional imaging providing local physiological parameters with high temporal and spatial resolution.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
S.R. Thomas “The Biomedical Applications of Fluorine-19 NMR”, in: “Magnetic Resonance Imaging”, Vol II, CL. Partain et al, ed., 2nd edition, W.B. Saunders Comp., Philadelphia, 1536 (1988).
B.S. Selinsky, and C.T. Burt, “In Vivo 19F NMR”, in: Biological Magnetic Resonance, Vol 11, L.J. Berlinger and J. Reuben ed., Plenum Press, New York 241 (1992).
R.P. Mason, Non-invasive Physiology: 19F NMR of perfluorocarbons, Biomat Artif. Cells Immob. Biotechnol, 22, in the press (1994).
A.V. Ratner, R. Hurd, H.H. Muller, B.B. Simpson, W. Pitts, D. Shibatu, C. Sotak, and S.W. Young 19F MR imaging of the reticuloendothelial system, Magn. Reson. Med. 5:548 (1988).
B. Barker, R.P. Mason, and R.M. Peshock, Echo planar imaging of perfluorocarbons, Magn. Reson. Imaging, 11, 1165 (1993).
T.L. Ceckler, S.L. Gibson, R. Hilf, and R.G. Bryant, In situ assessment of tumor vascularity using fluorine NMR imaging, Magn. Reson. Med. 13:416 (1990).
C.A. Branch, J.R. Ewing, J.A. Helpern, R.J. Ordidge, S. Butt, and M. A. Welch, Atraumatic quantitation of cerebral perfusion in cats by 19F magnetic resonance imaging, Magn. Reson. Med. 28:39 (1992).
V.D. Mehta, P.V. Kulkarni, S.B. Rajur, R.P. Mason, E.E. Babcock, A. Constantinescu, and P.P. Antich, Novel molecular probes for 19F magnetic resonance imaging: synthesis & characterization of fluorinated polymers, Biomed. Chem. Letters, 2:527 (1992).
V.D. Mehta, P.V. Kulkarni, R.P. Mason, and P.P. Antich, Fluorinated macromolecular probes for non-invasive assessment of pH by magnetic resonance spectroscopy, Biomed. Chem. Letters. 3:187 (1993).
V.D. Mehta, S. Aravind, P.V. Kulkarni, R.P. Mason, and P.P. Antich, Fluorinated macromolecular probes as biosensors for non-invasive assessment of pH with magnetic resonance spectroscopy, J. Nucl. Med. 34:124 (1993).
V.D. Mehta, P.V. Kulkarni, R.P. Mason, A. Constantinescu, and P.P. Antich, Fluorinated proteins as new 19F magnetic resonance imaging and spectroscopy agents, 204th American Chemical Society National Meeting, (Division of Medicinal Chemistry), Washington, D.C., August 23–28, 1992.
V.D. Mehta, P.V. Kulkarni, R.P. Mason, A. Constantinescu, and P.P. Antich, Fluorinated proteins as potential 19F magnetic resonance imaging and spectroscopy agents, Bioconj. Chem. 5(3), 257 (1994).
J.L. Evelhoch, and J.J.H. Ackerman, NMR T1 measurements in inhomogenous B1 with surface coils, J. Magn. Reson. 53:52 (1983).
A.V. Ratner, S. Quay, H.H. Muller, B.B. Simpson, R. Hurd, and S.W. Young, 19f relaxation rate enhancement and frequency shift with Gd-DTPA, Invest. Radiol, 24:224 (1989).
B. Gong, M. Gill, D.B. Washburn, W.C. Davenport, D. Adams, and L. Kwock, Parameter optimization and calibaration of 19F magnetic resonance imaging at 1.5 tesla, Magn. Reson. Imaging. 9:101 (1991).
R.P. Mason, P.P. Antich, E.E. Babcock, J. Gerberich, and R.L. Nunnally, Perfluorocarbon imaging in vivo: A 19F MRI study in tumor-bearing mice, Magn. Reson. Imaging. 7:475 (1989).
M.D. Ogan, U. Schmiedl, M.E. Moseley, W. Grodd, H. Paajanen, and R.C. Brasch, Albumin labeled with Gd-DTPA an intravascular contrast-enhancing agent for magnetic resonance blood imaging: preparation and characterization, Invest. Radiol 22:665 (1987).
A. Daugherty, N.N. Becker, L.A. Scherrer, B.E. Sobel, J.J.H. Ackerman, J.W. Baynes and S.R. Thorpe, Non-invasive detection of protein metabolism in vivo by n.m.r. spectroscopy, Biochem. J. 264:829 (1989).
R.P. Mason, N. Bansal, E.E. Babcock, R.L. Nunnally, and P.P. Antich, A novel editing technique for 19F MRI: molecule-specific imaging, Magn. Reson. Imaging, 8:729 (1990).
D.M. Freeman, H.H. Muller, R.E. Hurd, and S.W. Young, Rapid 19F Magnetic resonance imaging of perfluorooctyl bromide in vivo, Magn. Reson. Imaging, 6:61 (1988).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Mehta, V.D., Mason, R.P., Kulkarni, P.V., Lea, P., Constantinescu, A., Antich, P.P. (1995). 19F MR Characterization of Fluorinated Proteins and Relaxation Rate Enhancement with Gd-DTPA for Faster Imaging. In: Emran, A.M. (eds) Chemists’ Views of Imaging Centers. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9670-4_34
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9670-4_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9672-8
Online ISBN: 978-1-4757-9670-4
eBook Packages: Springer Book Archive