Abstract
Over the past several years we have been investigating the effects of unilateral naris closure on the olfactory system of adult mice. Unilateral closure creates an experimental situation in which conditions within the open-side nasal cavity are generally harsher than normal, while conditions on the closed side are generally milder. Because rodents are obligatory nasal breathers, unilateral closure forces all respiratory flows to pass through the open side. This exposes the open side to more odors, xenobiotics, dry air, pathogens and particulate matter than the closed side or normal nasal cavities. In addition. naris closure eliminates the nasal cycle (a pattern of alternating airflow between the two sides of the nose; see Ritter. 1970: Eccles. 1978; Cole and Haight, 1986). We believe that these conditions create a chronic low level of trauma for the open side. while not negatively affecting the closed side. Our studies have examined the effects of unilateral naris closure on: 1) morphology of the olfactory epithelium: 2) rate of mitosis of the neuronal stem cells of the epithelium: and 3) expression of the xenobiotic metabolizing enzyme, cytochrome P-450.
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References
Baron, J., Burke. J., Guengerich, F., Jakoby. W. and Voigt. J.. 1988, Sites for xenobiotic activation and detoxication within the respiratory tract: implications for chronically induced toxicity. Toxicol. Appl. Pharmacol. 93, 493–505.
Camara, C. and Harding. J., 1984, Thymidine incorporation in the olfactory epithelium of mice: early exponential response induced by olfactory neurectomy Brain Res., 308, 63–68.
Cole, P. and Haight. J.S., 1986, Posture and the nasal cycle Ann. Otol. Rhinol. Laryngol., 95. 233–237.
Dahl. A.. 1988, The effect of cytochrome P-450-dependent metabolism and other enzyme activities on olfaction. iL “Molecular Neurobiology of the Olfactory System,” F. Margolis and T. Getchell, eds., Plenum Press. New York.
Eccles, R.. 1978. The domestic pig as an experimental animal for studies on the nasal cycle Acta Otolaryngol.. 85. 431–436.
Fry. F.A. and Black. A.. 1973. Regional deposition and clearance of particles in the human nose. Aerosol Sci. 4. 113.
Graziadei. P.P.C. and DeHan, R.S.. 1973, Neuronal regeneration in frog olfactory system J. Cell Biol.. 59. 525–530.
Graziadei. P. and Metcalf. J., 1971, Autoradiographic and ultrastructural observations on the frog’s olfactory mucosa, Z, Zellforsch. 116, 305–318.
Hallworth, G.W. and Padfield, J.M., 1986, A comparison of the regional deposition in a model nose of a drug discharged from metered aerosol and metered-pump nasal delivery systems., T. Al Lerpy Clin. Tnimmnol. 77, 348.
Heyder, J. and Rudolf. G., 1975, Deposition of aerosol particles in the human nose, in “Inhaled Particles IV. Part 4,”W.H. Walton. ed., Pergamon Press. Oxford.
Maruniak, J.A., Lin, P. and Henegar, J., 1989, Effects of unilateral naris closure on the olfactory epithelia of adult mice. Brain Res. 490, 212.
Maruniak, J.A.. Henegar, J.R. and Sweeney. T.P.. 1990, Effects of long-term unilateral naris closure on the olactory epithelia of adult mice, Brain Res. 526, 65.
Matulionis. D.H.. 1975, Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration.,Zy Anat.. 142. 67–90.
Monti-Graziadei. G. and Graziadei. P.P.C., 1979, Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy, J. Neurocytol., 8, 197–213.
Monti-Graziadei. G. Karlan, M., Bernstein. J. and Graziadei, P.. 1980.
Reinnervation of the olfactory bulb after section of the olfactory nerve in monkey (Saimiri sciureus) Brain Res. 189. 343–354.
Moulton. D.G., 1974. Dynamics of cell populations in the olfactory epithelium. Ann. N.V. Acad. Sci. 237. 52–61.
Nef. P., Heldman. J., Lazard. D.. Margalit, T., Jaye, M.. Hanokoglu. I. and Lancet. D., 1989, Olfactory-specific cytochrome P450: cDNA cloning of a novel neuroepithelial enzyme possibly involved in chemoreception. Biol. Chem. 264. 6780.
Ritter. F.N., 1970, The vasculature of the nose Ann. Otol. Rhinnt. J,arynpnl., 779, 468–474.
Samanen. D.W. and Forbes. W.B., 1984. Replication and differentiation of olfactory receptor neurons following axotomy in the adult hamster: A morphometric analysis of postnatal neurogenesis, J. Comp. NPurol. 225. 201–211.
Voigt, J.. Geungerich, F. and Baron, J.. 1985, Localization of a cytochrome P-450 isozyme (cytochrome P-450 PB-B) and NADPH-cytochrome P-450 reductase in rat nasal mucosa. Cancer Lett. 27, 241.
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© 1992 Springer Science+Business Media New York
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Maruniak, J., Corotto, F., Walters, E. (1992). Effects of Naris Closure on the Olfactory Epithelia of Adult Mice. In: Doty, R.L., Müller-Schwarze, D. (eds) Chemical Signals in Vertebrates 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9655-1_4
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DOI: https://doi.org/10.1007/978-1-4757-9655-1_4
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