Abstract
In 1972, Doll et al.1 suggested that the concentration of 2-naphthylamine in cigarette smoke was similar to concentrations found in coal plants, i.e. a setting where an elevated risk of bladder cancer was identified. Subsequent chemical analyses of tobacco smoke2 showed that several aromatic amines were present, with higher concentrations in black (air-cured) tobacco. This suggested that in countries where prevalently black tobacco is smoked the relative risk for bladder cancer could be higher than in countries, such as the U. K. and U. S. where blond (flue-cured) tobacco is used.
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R. Doll, H. P. Vessey, R. W. R. Beasely, A. R. Buckley, E. C. Fear, R. E. W. Fisher, E. T. Gammon, W. Gunn, G. O. Hughes, K. Lee and B. Norman-Smith, Mortality of gas-workers: Final report of a prospective study, Br. J. Industr. Med. 29:394 (1972).
C. Patrianakos and O. Hoffman, Chemical studies of tobacco smoke, LXIV. On the analysis of aromatic amines in cigarette smoke, J. Anal. Chem. 3:150 (1979).
P. Vineis, J. Esteve and B. Terracini, Bladder cancer and smoking in males: types of cigarettes, age at start, effect of stopping and interaction with occupation, Int. J. Cancer 34:165 (1984).
J. Iscovich, R. Castelleto, J. Esteve, N. Munoz, R. Colanzi, A. Coronel, I. Deamezola, V. Tassi and A. Arslan, Tobacco smoking, occupational exposure, and bladder cancer in Argentina, Int. J. Cancer in press.
E. Mohtashamipur, K. Norpoth and F. Lieder, Urinary excretion of mutagens in smokers of cigarettes with various tar and nicotine yelds, black tobacco, and cigars, Cancer Lett., 34:103-112.
T. H. Connor, V. M. S. Ramanujam, J. B. Ward, Jr. and M. S. Legator, The identification and characterization of a urinary mutagen resulting from cigarette smoke, Mutat. Res. 113:161 (1983).
M. S. Bryant, P. Vineis, P. L. Skipper and S. R. Tannenbaum, Hemoglobin adducts of 4-aminobiphenyl: correlation with relative risks for bladder cancer in cigarette smokers, submitted for publication. 8. S. R. Tannenbaum, M. S. Bryant, P. L. Skipper and M. McLure, Hemoglobin adducts of tobacco-related aromatic amines: application to molecular epidemiology, Banbury Report 23:63 (1986).
P. Hartge, D. Silverman, R. Hoover, C. Schairer, R. Altman, D. Austin, K. Cantor, M. Child, C. Key, L. Marrett, T. J. Mason, J. W. Meigs, M. H. Myers, A. Narayana, J. W. Sullivan, G. M. Swanson, D. Thomas and D. West, Changing cigarette habits and bladder cancer risk: a case-control study, J. Natl. Cancer Inst. 78:1119 (1987).
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 38, Tobacco smoking, International Agency for Research on Cancer, Lyon (1986).
N. E. Day, Epidemiological data and multistage carcinogenesis, in: “Models, Mechanisms and Etiology of Tumor Promotion”, M. Borzsonyi, K. Lapin, N. E. Day and H. Yamasaki, eds., IARC Sci. Publ. No. 56, International Agency for Research on Cancer, Lyon (1985).
P. Vineis and J. Esteve, Temporal aspects of bladder carcinogenesis, Toxicol. Pathol. in press (1987).
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Suppl. 4 (volumes 1-29), Chemicals, Industrial Processes and Industries Associated with Cancer in Humans, Lyon (1982).
P. Vineis, J. Esteve, P. Hartge, R. Hoover, D. T. Silverman and B. Terracini, Cigarette-induced bladder cancer: the effects of timing and type of tobacco, Cancer Res, in press.
J. Lewalter and V. Korallus, Blood protein conjugates and acetylation of aromatic amines, Int. Arch. Qccup. Environ. Health 56:176 (1985).
R. Cartwright, R. A. Ahmad, D. Barham-Hall, R. W. Glashan, H. J. Rogers, E. Higgins and M. A. Kahn, Role of N-acetyltransferase phenotypes in bladder carcinogenesis: a pharmacogenetic epidemiologic approach to bladder cancer, Lancet 2:842 (1982).
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Vineis, P., Terracini, B. (1988). Epidemiological Approach to the Investigation of Mechanisms of Action in Human Bladder Carcinogenesis. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_70
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DOI: https://doi.org/10.1007/978-1-4757-9640-7_70
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