Epidemiological Approach to the Investigation of Mechanisms of Action in Human Bladder Carcinogenesis
In 1972, Doll et al.1 suggested that the concentration of 2-naphthylamine in cigarette smoke was similar to concentrations found in coal plants, i.e. a setting where an elevated risk of bladder cancer was identified. Subsequent chemical analyses of tobacco smoke2 showed that several aromatic amines were present, with higher concentrations in black (air-cured) tobacco. This suggested that in countries where prevalently black tobacco is smoked the relative risk for bladder cancer could be higher than in countries, such as the U. K. and U. S. where blond (flue-cured) tobacco is used.
KeywordsBladder Cancer Aromatic Amine Male Smoker Bladder Cancer Risk Coal Plant
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