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The Wound Response as a Key Element for an Understanding of Multistage Carcinogenesis in Skin

  • Chapter
Chemical Carcinogenesis

Abstract

The general appearance of skin carcinoma is that of a steadily growing wound. Thus, Haddow’s famous affirmation “the wound may be regarded as a tumor which heals itself”1 may be also read the other way around, i.e. that a tumor may be regarded as a wound which does not heal. A huge amount of literature dealing with the assumed relationship between wound repair and carcinogenesis has indeed been accumulated (see ref. 1, 6). Only very recently, however, the methods of cell biology, biochemistry and molecular biology have reached a level where they enable the investigator to proof this relationship in clear-cut experimental approaches aiming at an understanding of the molecular mechanisms involved in both wound repair and carcinogenesis. One of the most exciting results of these novel approaches is the discovery that the majority of proto-oncogenes code for components of cellular pathways which are required for the transduction of growth-stimulating signals, especially of those provided by the peptide growth factors2. While the physiological role of such growth factors is still not entirely understood, there is accumulating evidence indicating that at least some of them (such as EGF, TGFα, TGFß, PDGF) may be involved in tissue repair and regeneration rather than in the control of everyday tissue growth3.

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Authors and Affiliations

  1. Institute of Biochemistry, German Cancer Research Center, Heidelberg, Germany

    Friedrich Marks, Gerhard Fürstenberger, Michael Gschwendt, Michael Rogers & Bärbel Schurich

  2. Kernforschungszentrum (Nuclear Research Center), Karlsruhe, Germany

    Bernd Kaina

  3. Institute of Medical Microbiology and Hygiene, University of Freiburg, Federal Republic of Germany

    Georg Bauer

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  1. Friedrich Marks
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  1. University of Sassari, Sassari, Italy

    Francesco Feo  & Renato Garcea  & 

  2. University of Cagliari, Cagliari, Italy

    Paolo Pani  & Amedeo Columbano  & 

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Marks, F. et al. (1988). The Wound Response as a Key Element for an Understanding of Multistage Carcinogenesis in Skin. In: Feo, F., Pani, P., Columbano, A., Garcea, R. (eds) Chemical Carcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9640-7_26

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