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Macrophages and Related Cells pp 223–259Cite as

Complement Receptors

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Part of the Blood Cell Biochemistry book series (BLBI,volume 5)

Abstract

Complement was first described as a heat-labile component in serum with bactericidal activity. It was subsequently found to also participate in many aspects of host defense against infection, including the initiation of inflammation, opsonization of microorganisms, and regulation of the immune response. To date, most, if not all, of the serum proteins that constitute the complement system have been identified and their activities characterized. Three types of interactions may be described for the complement proteins: (i) with each other, resulting in the sequential activation of the complement components in a cascade manner as well as in the regulation of such activation; (ii) with surface components of target cells, leading to their opsonization by the covalent binding of activated C3 and C4 fragments, and their cytolysis by the insertion of the terminal complex into the membrane; and (iii) with receptors on cells and tissues to bring about various immunologic responses. In this chapter, the structure and function of the complement receptors on the macrophage and related cells are described.

Keywords

  • Phorbol Ester
  • Complement Receptor
  • Human Complement
  • Membrane Cofactor Protein
  • Lung Surfactant Protein

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  • Ahearn, J. M., and Fearon, D. T., 1989, Structure and function of the complement receptors, CR (CD35) and CR (CD21), Adv. Immunol. 46: 183–219.

    PubMed  CAS  CrossRef  Google Scholar 

  • Altieri, D. C., and Edgington, T. S., 1988a, A monoclonal antibody reacting with distinct adhesion molecules defines a transition in the functional state of the receptor CD1 lb/CD18 (Mac-1), J. Immunol. 141: 2656–2660.

    PubMed  CAS  Google Scholar 

  • Altieri, D. C., and Edgington, T. S., 1988b, The saturable high affinity association of factor X to ADP-stim- ulated monocytes defines a novel function of the Mac-1 receptor, J. Biol. Chem. 263: 7007–7015.

    PubMed  CAS  Google Scholar 

  • Altieri, D. C., Bader, R., Mannucci, P. M., and Edgington, T. S., 1988a, Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen, J. Cell Biol. 107: 1893–1900.

    PubMed  CAS  CrossRef  Google Scholar 

  • Altieri, D. C., Morrissey, J. H., and Edgington, T. S., 1988b, Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: An alternative initiation of the coagulation protease cascade, Proc. Natl. Acad. Sci. USA 85: 7462–7466.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ambrus, J. L., Peters, M. G., Fauci, A. S., and Brown, E. J., 1990, The Ba fragment of complement factor B inhibits human B lymphocyte proliferation, J. Immunol. 144: 1549–1553.

    PubMed  CAS  Google Scholar 

  • Arnaout, M. A., 1990, Leukocyte adhesion molecules deficiency: Its structural basis, pathophysiology and implications for modulating the inflammatory response, Immunol. Rev. 114: 145–180.

    PubMed  CAS  CrossRef  Google Scholar 

  • Arnaout, M. A., Todd, R. F., Dana, N., Melamed, J., Schlossman, S. F., and Colten, H. R., 1983, Inhibition of phagocytosis of complement C3– or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol), J. Clin. Invest. 72: 171–179.

    PubMed  CAS  CrossRef  Google Scholar 

  • Arnaout, M. A., Gupta, S. K., Pierce, M. W., and Tenen, D. G., 1988a, Amino acid sequence of the alpha subunit of human leukocyte adhesion receptor Mol (complement receptor type 3), J. Cell Biol. 106: 2153–2158.

    PubMed  CAS  CrossRef  Google Scholar 

  • Arnaout, M. A., Lanier, L. L., and Faller, D. V., 1988b, Relative contribution of the leukocyte molecules Mol, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue-and stimulus-specific, J. Cell. Physiol. 137: 305–309.

    PubMed  CAS  CrossRef  Google Scholar 

  • Arvieux, J., Reboul, A., Bensa, J. C., and Colomb, M. G., 1984, Characterization of the C 1 q receptor on a human macrophage cell line U937, Biochem. J. 218: 547–555.

    PubMed  CAS  Google Scholar 

  • Atkinson, J. P., and Frank, M. M., 1974, The effect of bacillus Calmette-Guerin induced macrophage activation on the in vivo clearance of sensitised erythrocytes, J. Clin. Invest. 53: 1742–1749.

    PubMed  CAS  CrossRef  Google Scholar 

  • Axline, S. G., and Reaven, E. P., 1974, Inhibition of phagocytosis and plasma membrane mobility of the cultivated macrophage by cytochalasin B: Role of subplasmalemmal microfilaments, J. Cell Biol. 62: 647–659.

    PubMed  CAS  CrossRef  Google Scholar 

  • Baatrup, G., Thiel, S., Isager, H., Svehag, S. E., and Jensenius, J. C., 1987, Demonstration in human plasma of a lectin activity analogous to that of bovine conglutinin, Scand. J. Immunol. 26: 355–361.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bainton, D. F., Miller, L. J., Kishimoto, T. K., and Springer, T. A., 1987, Leukocyte adhesion receptors are stored in peroxidase-negative granules of human neutrophile, J. Exp. Med. 166: 1641–1653.

    PubMed  CAS  CrossRef  Google Scholar 

  • Barlow, P. N., Baron, M., Norman, D. G., Day, A. J., Willis, A. C., Sim, R. B., and Campbell, I. D., 1991, Secondary structure of a complement control protein module by two-dimensional ‘H NMR, Biochemistry 30: 997–1004.

    PubMed  CAS  CrossRef  Google Scholar 

  • Becherer, J. D., and Lambris, J. D., 1988, Identification of the C3b receptor-binding domain in third component of complement, J. Biol. Chem. 263: 14586–14591.

    PubMed  CAS  Google Scholar 

  • Becherer, J. D., Alsenz, J., and Lambris, J. D., 1989, Molecular aspects of C3 interactions and structural/ functional analysis of C3 from different species, Curr. Top. Microbiol. Immunol. 153: 45–72

    CrossRef  Google Scholar 

  • Becker, E. L., Kermode, J. L., Naccache, P. H., Yassin, R., Marsh, M. L., Munoz, I. J., and Sha’afi, R. I., 1985, The inhibition of neutrophil granule enzyme secretion and chemotaxis by pertussis toxin, J. Cell. Biol. 100: 1641–1646.

    PubMed  CAS  CrossRef  Google Scholar 

  • Becker, S., Hadding, U., Schorlemmer, H. U., and Bitter-Suermann, D., 1978a, Demonstration of highaffinity binding sites for C3a anaphylatoxin on guinea-pig platelets, Scand. J. Immunol. 8: 551–555

    PubMed  CAS  CrossRef  Google Scholar 

  • ecker, S., Meuer, S., Hadding, U., and Bitter-Suermann, D., 1978b, Platelet activation: A new biological activity of guinea-pig C3a anaphylatoxin, Scand. J. Immunol. 7: 173–180.

    CrossRef  Google Scholar 

  • Beer, J., and Coller, B. S., 1989, Evidence that platelet glycoprotein IIIa has a large disulfide-bonded loop that is susceptible to proteolytic cleavage, J. Biol. Chem. 264: 17564–17573.

    PubMed  CAS  Google Scholar 

  • Beller, D. I., Springer, T. A., and Schreiber, R. D., 1982, Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor, J. Exp. Med. 156: 1000–1009.

    PubMed  CAS  CrossRef  Google Scholar 

  • Belt, K. T., Carroll, M. C., and Porter, R. R., 1984, The structural basis of the multiple forms of human complement component C4, Cell 36: 907–914.

    PubMed  CAS  CrossRef  Google Scholar 

  • Belt, K. T., Yu, C. Y., Carroll, M. C., and Porter, R. R., 1985, Polymorphism of human complement component C4, Immunogenetics 21: 173–180.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ben-Chetrit, E., Chan, E. K. L., Sullivan, K. F., and Tan, E. M., 1988, A 52–KD protein is a novel component of the SS-A/Ro antigenic particle, J. Exp. Med. 167: 1560–1571.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bentley, D. R., 1986, Primary structure of human complement component C2: Homology to two unrelated protein families, Biochem. J. 239: 339–345.

    PubMed  CAS  Google Scholar 

  • Berger, M., Gaither, T. A., Hammer, C. H., and Frank, M. M., 1981, Lack of binding of human C3, in its native state, to C3b receptors, J. Immunol. 127: 1329–1334.

    PubMed  CAS  Google Scholar 

  • Berger, M., O’Shea, J., Cross, A. S., Folks, T. M., Chused, T. M., Brown, E. J., and Frank, M. M., 1984, Human neutrophils increase expression of C3bi as well as C3b receptors upon activation, J. Clin. Invest. 74: 1566–1571.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bianco, C., Griffin, F. M., and Silverstein, S. C., 1975, Studies of the macrophage complement receptor: Alteration of receptor function upon macrophage activation, J. Exp. Med. 141: 1279–1290.

    CrossRef  Google Scholar 

  • Bitter-Suermann, D., 1988, The anaphylatoxins, in The Complement System ( K. Rother and G. O. Till, eds.), pp. 367–395, Springer-Verlag, Berlin.

    Google Scholar 

  • Bobak, D. A., Gaither, T. A., Frank, M. M., and Tenner, A. J., 1987, Modulation of FcR function by complement: Subcomponent Clq enhances the phagocytosis of IgG-opsonized targets by human monocytes and culture-derived macrophages, J. Immunol. 138: 1150–1156.

    PubMed  CAS  Google Scholar 

  • Bobak, D. A., Frank, M. M., and Tenner, A. J., 1988a, CIq acts synergistically with phorbol dibutyrate to activate CR1–mediated phagocytosis by human mononuclear phagocytes, Eur. J. Immunol. 18: 2001–2007.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bobak, D. A., Washburn, R. G., and Frank, M. M., 1988b, CI q enhances the phagocytosis of Cryptococcus neofbrmans blastospores by human monocytes, J. Immunol. 141: 592–597.

    PubMed  CAS  Google Scholar 

  • Bohnsack, J. F., Kleinman, H. K., Takahashi, T., O’Shea, J. J., and Brown, E. J., 1985, Connective tissue proteins and phagocytic cell function. Laminin enhances complement and Fe-mediated phagocytosis by cultured human macrophages, J. Exp. Med. 161: 912–923.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bohnsack, J. F., Akiyama, S. K., Damsky, C. H., Knape, W. A., and Zimmerman, G. A., 1990, Human neutrophil adherence to laminin in vitro: Evidence for a distinct neutrophil integrin receptor for laminin, J. Exp. Med. 171: 1221–1237.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bokisch, V. A., and Müller-Eberhard, H. J., 1970, Anaphylatoxin inactivator of human plasma: Its isolation and characterization as a carboxypeptidase, J. Clin. Invest. 49: 2427–2436.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bokisch, V. A., Müller-Eberhard, H. J., and Cochrane, C. G., 1969, Isolation of a fragment (C3a) of the third component of human complement containing anaphylatoxin and chemotactic activity and description of an anaphylatoxin inactivator of human serum, J. Exp. Med. 129: 1109–1130.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bora, N. S., Lublin, D. M., Kumar, B. V., Hockett, R. D., Holers, V. M., and Atkinson, J. P., 1989

    Google Scholar 

  • Structural gene for human membrane cofactor protein (MCP) of complement maps to within 100 kb of the 3’ end of the C3b/C4b receptor gene, J. Exp. Med. 169:597–602.

    Google Scholar 

  • Boulay, F., Tardif, M., Brouchan, L., and Vignais, P., 1990, The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors, Biochemistry 29: 11123–11133.

    PubMed  CAS  CrossRef  Google Scholar 

  • Boulay, F., Mery, L., Tardif, M., Brouchon, L., and Vignais, P., 1991, Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells, Biochemistry 30: 2993–2999.

    PubMed  CAS  CrossRef  Google Scholar 

  • Brown, E. J., and Goodwin, J. L., 1988, Fibronectin receptors of phagocytes: Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes, J. Exp. Med. 167: 777–793.

    PubMed  CAS  CrossRef  Google Scholar 

  • Brown, E. J., Bohnsack, J. F., and Gresham, H. D., 1988, Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen, J. Clin. Invest. 81: 365–375.

    PubMed  CAS  CrossRef  Google Scholar 

  • Bullock, W. E., and Wright, S. D., 1987, Role of the adherence-promoting receptors, CR3, LFA-1, and p150,95, in binding of Histoplasma capsulatum by human macrophages, J. Exp. Med. 165: 195–210.

    PubMed  CAS  CrossRef  Google Scholar 

  • Burmeister, M., Kim, S., Price, R., de Lange, T., Tantravahi, U., Myers, R. M., and Cox, D. R., 1991, A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis, Genomics 9: 19–30.

    PubMed  CAS  CrossRef  Google Scholar 

  • Burton, D. R., and Woof, J. M., 1992, Human antibody effector function, Adv. Immunol. 51: 1–84.

    PubMed  CAS  CrossRef  Google Scholar 

  • Buyon, J. P., Slade, S. G., Reibman, J., Abramson, S. B., Philips, M. R., Weissmann, G., and Winchester, R., 1990, Constitutive and induced phosphorylation of the a-and ß-chains of the CD!1 /CD 18leukocyte integrin family, J. Immunol. 144: 191–197.

    PubMed  CAS  Google Scholar 

  • Calvete, J. J., Alvarez, M. V., Rivas, G., Hew, C. L., Henschen, A., and Gonzalez-Rodriguez, J., 1989a, Interchain and intrachain disulphide bonds in human platelet glycoprotein IIb. Localization of the epitopes for several monoclonal antibodies, Biochem. J. 261: 551–560.

    PubMed  CAS  Google Scholar 

  • Calvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J., 1989b, Complete localization of the intrachain disulphide bonds and the N-glycosylation points in the alpha-subunit of human platelet glycoprotein IIb, Biochem. J. 261: 561–568.

    PubMed  CAS  Google Scholar 

  • Calvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J., 1991, Assignment of disulphide bonds in human platelet GPIIIa: A duslphide pattern for the ß-subunits of the integrin family, Biochem. J. 274: 63–71.

    PubMed  CAS  Google Scholar 

  • Campbell, R. D., Dodds, A. W., and Porter, R. R., 1980, The binding of human complement component C4 to antibody-antigen aggregates, Biochem. J. 189: 67–80.

    PubMed  CAS  Google Scholar 

  • Campbell, R. D., Gagnon, J., and Porter, R. R., 1981, Amino acid sequence around the thiol and reactive acyl groups of human complement component C4, Biochem. J. 199: 359–370.

    PubMed  CAS  Google Scholar 

  • Caporale, L. H., Tippett, P. S., Ericson, B. W., and Hugh, T. E., 1980, The active site of C3a anaphylatoxin, J. Biol. Chem. 255: 10758–10763.

    PubMed  CAS  Google Scholar 

  • Caras, I. W., Davitz, M. A., Rhee, L., Weddell, G., Martin, D. W. J., and Nussenzweig, V., 1987, Cloning of decay-accelerating factor suggests novel use of splicing to generate two proteins, Nature (London) 325: 545–549.

    CAS  Google Scholar 

  • Carlo, J. R., Ruddy, S., Studer, E. J., and Conrad, D. H., 1979, Complement receptor binding of C3b- coated cells treated with C3b inactivator, ß1H globulin and trypsin, J. Immunol. 123: 523–528.

    PubMed  CAS  Google Scholar 

  • Carrell, N. A., Fitzgerald, L. A., Steiner, B., Erickson, H. P., and Phillips, D. R., 1985, Structure of human platelet membrane glycoproteins IIb and IIIa as determined by electron microscopy, J. Biol. Chem. 260: 1743–1749.

    PubMed  CAS  Google Scholar 

  • Carroll, M. C., Alicot, E. M., Katzman, P. J., Klickstein, L. B., Smith, J. A., and Fearon, D. T., 1988, The organization of the genes encoding complement receptors type 1 and 2, decay-accelerating factor, and C4–binding protein in the RCA locus on human chromosome 1, J. Exp. Med. 167: 1271–1280.

    PubMed  CAS  CrossRef  Google Scholar 

  • Changelian, P. S., and Fearon, D. T., 1986, Tissue-specific phosphorylation of complement receptors CR1 and CR2, J. Exp. Med. 163: 101–115.

    PubMed  CAS  CrossRef  Google Scholar 

  • Chatila, T. A., Geha, R. S., and Arnaout, M. A., 1989, Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules, J. Cell Biol. 109: 3435–3444.

    PubMed  CAS  CrossRef  Google Scholar 

  • Chazin, W. J., Hugh, T. E., and Wright, P. E., 1988, ‘H NMR studies of human C3a anaphylatoxin in solution: Sequential resonance assignments, secondary structure, and global fold, Biochemistry 27: 9139–9148.

    Google Scholar 

  • Chenoweth, D. E., 1986, Complement mediators of inflammation, in Immunobiology of the Complement System. An Introduction for Research and Clinical Medicine ( G. D. Ross, ed.), pp. 63–86, Academic Press, Orlando, Fla.

    Google Scholar 

  • Chenoweth, D. E., and Hugh, T. E., 1978, Demonstration of specific C5a receptor on intact human polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. USA 75: 3943–3947.

    PubMed  CAS  CrossRef  Google Scholar 

  • Chou, P. Y., and Fasman, G. D., 1978, Empirical predictions of protein conformation, Annu. Rev. Biochem. 47: 251–276.

    PubMed  CAS  CrossRef  Google Scholar 

  • Chung, L. P., Bentley, D. R., and Reid, K. B. M., 1985, Molecular cloning and characterisation of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system, Biochem. J. 230: 133–141.

    PubMed  CAS  Google Scholar 

  • Clas, F., Euteneuer, B., Stemmer, F., and Loos, M., 1989, Interaction of fluid phase Cl/Cl q and macro- phage membrane-associated Clq with gram-negative bacteria, Behring Inst. Mitt. 84: 236–254.

    PubMed  CAS  Google Scholar 

  • Cochrane, C. G., and Müller-Eberhard, H. J., 1968, The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement, J. Exp. Med. 127: 371–386.

    PubMed  CAS  CrossRef  Google Scholar 

  • Codina, J., Hildebrandt, J., Iyengar, R., Birnbaumer, L., Sekura, R. D., and Manclark, C. R., 1983, Pertussis toxin substrate, the putative Ni component of adenylyl cyclase, is an alpha-beta heterodimer regulated by guanine nucleotide and magnesium, Proc. Natl. Acad. Sci. USA 80: 4276–4280.

    PubMed  CAS  CrossRef  Google Scholar 

  • Coller, B. S., 1985, A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex, J. Clin. Invest. 76: 101–108.

    PubMed  CAS  CrossRef  Google Scholar 

  • Cooper, J. A., Lo, S. K., and Malik, A. B., 1988, Fibrin is a determinant of neutrophil sequestration in the lung, Circ. Res. 63: 735–741.

    PubMed  CAS  CrossRef  Google Scholar 

  • Cooper, N. R., 1969, Immune adherence by the fourth component of complement, Science 165: 396–398.

    PubMed  CAS  CrossRef  Google Scholar 

  • Corbi, A. L., Miller, L. J., O’Connor, K., Larson, R. S., and Springer, T. A., 1987, cDNA cloning and complete primary structure of the a subunit of a leukocyte adhesion glycoprotein, p150,95, EMBO J. 6: 4023–4028.

    Google Scholar 

  • Corbi, A. L., Kishimoto, T. K., Miller, L. J., and Springer, T. A., 1988a, The human leukocyte adhesion glycoprotein Mac-1 (complement receptor type 3, CD 11 b) a subunit: Cloning, primary structure, and relation to the integrins, von Willebrand factor and factor B, J. Biol. Chem. 263: 12403–12411.

    PubMed  CAS  Google Scholar 

  • Corbi, A. L., Larson, R. S., Kishimoto, T. K., Springer, T. A., and Morton, C. C., 1988b, The leukocyte adhesion receptors LFA-1, Mac-1 and p150,95: Identification of a gene cluster involved in cell adhesion, J. Exp. Med. 167: 1597–1607.

    PubMed  CAS  CrossRef  Google Scholar 

  • Cornacoff, J. B., Herbert, L. A., Smead, W. L., Vanaman, M. E., Birmingham, D. J., and Waxman, F. J., 1983, Primate erythrocyte immune-complex clearing mechanism, J. Clin. Invest. 71: 236–247

    PubMed  CAS  CrossRef  Google Scholar 

  • Craddock, P. R., Hammerschmidt, D., White, J. G., Dalmasso, A. P., and Jacob, H. S., 1977, Complement (C5a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostatis and leukopenia, J. Clin. Invest. 60: 260–264.

    PubMed  CAS  CrossRef  Google Scholar 

  • Dana, N., Fathallah, D. M., and Arnaout, M. A., 1991, Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18, Proc. Natl. Acad. Sci. USA 88: 3106–3110.

    PubMed  CAS  CrossRef  Google Scholar 

  • Davis, A. E., and Lachmann, P. J., 1984, Bovine conglutinin is a collagen-like protein, Biochemistry 23: 2139–2144.

    PubMed  CAS  CrossRef  Google Scholar 

  • Davis, A. E., Harrison, R. A., and Lachmann, P. J., 1984, Physiologic inactivation of fluid phase C3b: Isolation and structural analysis of C3c, C3dg (a2D) and C3g, J. Immunol. 132: 1960–1966.

    PubMed  CAS  Google Scholar 

  • Day, A. J., Ripoche, J., Willis, A. C., and Sim, R. B., 1987, Structure and polymorphism of human factor H, Complement 4: 147–148.

    Google Scholar 

  • de Bruijn, M. H. L., and Fey, G. H., 1985, Human complement component C3: cDNA coding sequence and derived primary structure, Proc. Natl. Acad. Sci. USA 82: 708–712.

    PubMed  CrossRef  Google Scholar 

  • del-Balzo, U., Polley, M. J., and Levi, R., 1989, C3a-induced contraction of guinea pig ileum consists of two components: Fast histamine-mediated and slow prostanoid-mediated, J. Pharmacol. Exp. Ther. 248: 1003–1009.

    PubMed  CAS  Google Scholar 

  • Diamond, M. S., Staunton, D. E., de Fougerolles, A. R., Stacker, S. A., Garcia-Aguilar, J., Hibbs, M. L., and Springer, T. A., 1990, ICAM-1 (CD54): A counter-receptor for Mac-1 (CD1 1 b/CD18), J. Cell Biol. 111: 3129–3139.

    PubMed  CAS  CrossRef  Google Scholar 

  • Diamond, M. S., Staunton, D. E., Marlin, S. D., and Springer, T. A., 1991, Binding of the integrin Mac-1 (CD1 lb/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation, Cell 65: 961–971.

    PubMed  CAS  CrossRef  Google Scholar 

  • DiScipio, R. G., and Hugli, T. E., 1989, The molecular architecture of human complement component C6, J. Biol. Chem. 264: 16197–16206.

    PubMed  CAS  Google Scholar 

  • DiScipio, R. G., Chakravarti, D. N., Müller-Eberhard, H. J., and Fey, G. H., 1988, The structure of human complement component C7 and C5b-7 complex, J. Biol. Chem. 263: 549–560.

    PubMed  CAS  Google Scholar 

  • Dransfield, I., and Hogg, N., 1989, Regulated expression of Mgt+ binding epitope on leukocyte integrin alpha subunits, EMBO J. 8: 3759–3765.

    PubMed  CAS  Google Scholar 

  • Drickamer, K., 1989, Multiple subfamilies of carbohydrate recognition domains in animal lectins, Ciba Found. Symp. 145: 45–58.

    PubMed  CAS  Google Scholar 

  • Dykman, T. R., Cole, J. L., Iida, K., and Atkinson, J. P., 1983, Polymorphism of the human erythrocyte C3b-C4b receptor, Proc. Natl. Acad. Sci. USA 80: 1698–1702.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ember, J. A., Johansen, N. L., and Hugli, T. E., 1991, Designing synthetic superagonists of C3a anaphylatoxin, Biochemistry 30: 3603–3612.

    PubMed  CAS  CrossRef  Google Scholar 

  • Erdei, A., 1990, Clq receptor on murine cells, J. Immunol. 145: 1754–1760.

    PubMed  CAS  Google Scholar 

  • Erdei, A., and Reid, K. B. M., 1988, The Clq receptor, Mol. Immunol. 25: 1067–1073.

    PubMed  CAS  CrossRef  Google Scholar 

  • Erdei, A., and Sim, R. B., 1987, Complement factor H-binding protein of Raji cells and tonsil B lymphocytes, Biochem. J. 246: 149–156.

    PubMed  CAS  Google Scholar 

  • Ezekowitz, R. A. B., Kuhlman, M., Groopman, J. E., and Byrn, R. A., 1989, A human serum mannosebinding protein inhibits in vitro infection by the human immunodeficiency virus, J. Exp. Med. 169: 185–196.

    PubMed  CAS  CrossRef  Google Scholar 

  • Fearon, D. T., 1980, Identification of the membrane glycoprotein that is the C3b receptor of the human erythrocyte, polymorphonuclear leukocyte, B lymphocyte and monocyte, J. Exp. Med. 152: 20–30.

    PubMed  CAS  CrossRef  Google Scholar 

  • Fearon, D. T., and Collins, L. A., 1983, Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures, J. Immunol. 130: 370–375.

    PubMed  CAS  Google Scholar 

  • Fernandez, H. N., and Hugh, T. E., 1978, Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin, J. Biol. Chem. 253: 6955–6964.

    PubMed  CAS  Google Scholar 

  • Fernandez, H. N., Henson, P. M., Otani, A., and Hugh, T. E., 1978, Chemotaxis response to human C3a and C5a anaphylatoxins. I. Evaluations of C3a and C5a leukotaxis in vitro and under simulated in vivo conditions, J. Immunol. 120: 109–115.

    PubMed  CAS  Google Scholar 

  • Floros, J., Steinbrink, R., Jacobs, K., Phelps, D., Kriz, R., Recny, M., Sultzman, L., Jones, S., Taeusch, H. W., Frank, H. A., and Fritch, E. F., 1986, Isolation and characterization of cDNA clones for the 35–kDa pulmonary surfactant-associated protein, J. Biol. Chem. 261: 9029–9033.

    PubMed  CAS  Google Scholar 

  • Friis-Christiansen, P., Thiel, S., Svehag, S. E., Dessau, R., Svendsen, P., Andersen, O., Laursen, S. B., and Jensenius, J. C., 1990, In vivo and in vitro antibacterial activity of conglutinin, a mammalian plasma lectin, Scand. J. Immunol. 31: 453–460.

    CAS  Google Scholar 

  • Fujita, T., Gigli, I., and Nussenzweig, V., 1978, Human C4–binding protein. II. Role in proteolysis of C4b by C3b-inactivator, J. Exp. Med. 148: 1044–1051.

    PubMed  CAS  CrossRef  Google Scholar 

  • Fukuoka, Y., and Hugh, T. E., 1988, Demonstration of a specific C3a receptor on guinea pig platelets, J. Immunol. 140: 3496–3501.

    PubMed  CAS  Google Scholar 

  • Gerard, C., and Hugh, T. E., 1981, Identification of classical anaphylatoxin as the des-Arg form of the C5a molecule: Evidence of a modulator role for the oligosaccharide unit in human des-Arg74–05a, Proc. Natl. Acad. Sci. USA 78: 1833–1837.

    PubMed  CAS  CrossRef  Google Scholar 

  • Gerard, N. P., and Gerard, C., 1990, Construction and expression of a novel recombinant anaphylatoxin, C5a-N 19, as a probe for the human C5a receptor, Biochemistry 29: 9274–9281.

    PubMed  CAS  CrossRef  Google Scholar 

  • Gerard, N. P., and Gerard, C., 1991, The chemotactic receptor for human C5a anaphylatoxin, Nature (London) 349: 614–617.

    CAS  CrossRef  Google Scholar 

  • Gerardy-Schahn, R., Ambrosius, D., Casaretto, M., Grötzinger, J., Saunders, D., Wollmer, A., Brandenburg, D., and Bitter-Suermann, D., 1988, Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements, Biochem. J. 255: 209–216.

    PubMed  CAS  Google Scholar 

  • Gerardy-Schahn, R., Ambrosius, D., Saunders, D., Casaretto, M., Mittler, C., Karwarth, G., Gorgen, S., and Bitter-Suermann, D., 1989, Characterization of C3a receptor-proteins on guinea pig platelets and human polymorphonuclear leukocytes, Eur. J. Immunol. 19: 1095–1102.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ghebrehiwet, B., 1989, Functions associated with the Clq receptor, Behring Inst. Mitt. 84: 204–215.

    PubMed  CAS  Google Scholar 

  • Ghebrehiwet, B., Silvestri, L., and McDevitt, C., 1984, Identification of the Raji cell membrane-derived Clq inhibitor as a receptor for human Clq. Purification and immunochemical characterization, J. Exp. Med. 160: 1375–1389.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ghebrehiwet, B., Habicht, G. S., and Beck, G., 1990, Interaction of Clq with its receptor on cultured cell lines induces an anti-proliferative response, Clin. Immunol. Immunopatho!. 54: 148–159.

    CAS  CrossRef  Google Scholar 

  • Goldman, D. W., Chang, F. H., Gifford, L. A., Goetzl, E. J., and Bourne, H. R., 1985, Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes, J. Exp. Med. 162: 145–156.

    PubMed  CAS  CrossRef  Google Scholar 

  • Gorski, J., Hugh, T. E., and Muller-Eberhard, H. J., 1979, C4a: The third anaphylatoxin of the human complement system, Proc. Natl. Acad. Sci. USA 76: 5299–5302.

    PubMed  CAS  CrossRef  Google Scholar 

  • Goundis, D., 1988, Structure, biosynthesis and cDNA cloning studies of properdin of the serum complement system, D. Phil. Thesis, Oxford University.

    Google Scholar 

  • Graham, I. L., and Brown, E. J., 1991, Extracellular calcium results in a conformational change in Mac-1 (CD11b/CD18) on neutrophils. Differentiation of adhesion and phagocytosis functions of Mac-1, J. Immunol. 146: 685–691.

    PubMed  CAS  Google Scholar 

  • Graham, I. L., Gresham, H. D., and Brown, E. J., 1989, An immobile subset of plasma membrane CD1lb/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors, J. Immunol. 14: 2352–2358.

    Google Scholar 

  • Greer, J., 1985, Model structure for the inflammatory protein C5a, Science 228: 1055–1060.

    PubMed  CAS  CrossRef  Google Scholar 

  • Gresham, H. D., Goodwin, J. L., Allen, P. M., Anderson, D. C., and Brown, E. J., 1989, A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis, J. Cell Biol. 108: 1935–1943.

    PubMed  CAS  CrossRef  Google Scholar 

  • Griffin, F. M., Jr., and Griffin, J. A., 1980, Augmentation of macrophage complement receptor function in vitro. II. Characterization of the effects of a unique lymphokine upon the phagocytic capabilities of macrophages, J. Immunol. 125: 844–849.

    PubMed  CAS  Google Scholar 

  • Griffin, F. M., Jr., and Mullinax, P. J., 1981, Augmentation of macrophage complement receptor function in vitro. III. C3b receptors that promote phagocytosis migrate within the plane of the macrophage plasma membrane, J. Exp. Med. 154: 291–305.

    PubMed  CAS  CrossRef  Google Scholar 

  • Griffin, J. A., and Griffin, F. M., Jr., 1979, Augmentation of macrophage complement receptor function in vitro. I. Characterization of the cellular interactions required for the generation of a T-lymphocyte product that enhances macrophage complement receptor function, J. Exp. Med. 150: 653–675.

    PubMed  CAS  CrossRef  Google Scholar 

  • Guan, E., Burgess, W. H., Robinson, S. L., Goodman, E. B., McTigue, K. J., and Tenner, A. J., 1991, Phagocytic cell molecules that bind the collagen-like region of Cl q. Involvement in the C 1 q-mediated enhancement of phagocytosis, J. Biol. Chem. 266: 20345–20355.

    PubMed  CAS  Google Scholar 

  • Haagsman, H. P., White, R. T., Schilling, J., Lau, K., Benson, B. J., Golden, J., Hawgood, S., and Clements, J. A., 1989, Studies of the structure of lung surfactant protein SP-A, Am. J. Physiol. 257: L421–L429.

    PubMed  CAS  Google Scholar 

  • Habicht, G. S., Beck, G., and Ghebrehiwet, B., 1987, C lq inhibits the expression of B lymphoblastoid cell line interleukin 1 (IL I), J. Immunol. 138: 2593–2597.

    PubMed  CAS  Google Scholar 

  • Haefliger, J. A., Tschopp, J., Vial, N., and Jenne, D. E., 1989, Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6, J. Biol. Chem. 264: 18041–18051.

    PubMed  CAS  Google Scholar 

  • Hamada, A., Young, J., Chmielewski, R. A., and Green, B. M., 1988, Clq enhancement of antibody-dependent granulocyte-mediated killing of nonphagocytosable targets in vitro, J. Clin. Invest. 82: 945–949.

    PubMed  CAS  CrossRef  Google Scholar 

  • Harlan, J. M., 1985, Leukocyte-endothelial interactions, Blood 65: 513–525.

    PubMed  CAS  Google Scholar 

  • Harrison, R. A., and Lachmann, P. J., 1980, The physiological breakdown of the third component of human complement, Mol. Immunol. 17: 9–20.

    PubMed  CAS  CrossRef  Google Scholar 

  • Harrison, R. A., Thomas, M. L., and Tack, B. F., 1981, Sequence determination of the thiolester site of the fourth component of human complement, Proc. Natl. Acad. Sci. USA 78: 7388–7392.

    PubMed  CAS  CrossRef  Google Scholar 

  • Hemler, M. E., 1990, VLA proteins in the integrin family: Structures, functions, and their role on leukocytes, Annu. Rev. Immunol. 8: 365–400.

    PubMed  CAS  CrossRef  Google Scholar 

  • Hickstein, D. D., Hickey, M. J., Ozols, J., Baker, D. M., Back, A. L., and Roth, G. J., 1989, cDNA sequence for the aM subunit of the human neutrophil adherence receptor indicates homology to integrin a subunits, Proc. Natl. Acad. Sci. USA 86: 257–261.

    Google Scholar 

  • Hillarp, A., and Dahlbäck, B., 1990, Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: Sequence homology with the alpha chain, Proc. Natl. Acad. Sci. USA 87: 1183–1187.

    PubMed  CAS  CrossRef  Google Scholar 

  • Hogg, N., Takacs, L., Palmer, D. G., Salvendran, Y., and Allen, C., 1986, The p 150,95 molecule is a marker of human mononuclear phagocytes: A comparison with expression of class II molecules, Eur. J. Immunol. 16: 240–248.

    PubMed  CAS  CrossRef  Google Scholar 

  • Holers, V. M., Chaplin, D. D., Leykam, J. F., Gruner, B. A., Kumar, V., and Atkinson, J. P., 1987, Human complement C3b/C4b receptor (CR1) mRNA polymorphism that correlates with the CR1 allelic molecular weight polymorphism, Proc. Natl. Acad. Sci. USA 84: 2459–2463.

    PubMed  CAS  CrossRef  Google Scholar 

  • Hourcade, D., Garcia, A. D., Post, T. W., Taillon-Miller, P., Holens, V. M., Wagner, L. M., Bora, N. S., and Atkinson, J. P., 1992, Analysis of the human regulators of complement activation (RCA) gene cluster with yeast artificial chromosomes (YACs), Genomics 12: 289–300.

    PubMed  CAS  CrossRef  Google Scholar 

  • Huber, R., Scholze, H., Pâques, E. P., and Deisenhofer, J., 1980, Crystal structure analysis and molecular model of human C3a anaphylatoxin, Hoppe-Seyler’s Z. Physiol. Chem. 361: 1389–1399.

    PubMed  CAS  CrossRef  Google Scholar 

  • Huey, R., and Hugli, T. E., 1985, Characterization of a C5a receptor on human polymorphonuclear leukocytes (PMN), J. Immunol. 135: 2063–2068.

    PubMed  CAS  Google Scholar 

  • Hugli, T. E., 1975, Human anaphylatoxin (C3a) from the third component of complement: Primary structure, J. Biol. Chem. 250: 8293–8301.

    PubMed  CAS  Google Scholar 

  • Hugh, T. E., 1981, The structural basis for anaphylatoxin and chemotactic functions of C3a, C4a and C5a, CRC Crit. Rev. Immunol. 1: 321–366.

    Google Scholar 

  • Hugli, T. E., 1989, Structure and function of C3a anaphylatoxin, Curr. Top. Microbiol. Immunol. 153: 181–208.

    CrossRef  Google Scholar 

  • Hugli, T. E., and Erickson, B. W., 1977, Synthetic peptides with the biological activities and specificity of human C3a anaphylatoxin, Proc. Natl. Acad. Sci. USA 74: 1826–1830.

    PubMed  CAS  CrossRef  Google Scholar 

  • Humphries, M. J., 1990, The molecular basis and specificity of integrin-ligand interactions, J. Cell Sci. 97: 585–592.

    PubMed  CAS  Google Scholar 

  • Iferroudjene, D., Schouft, M. T., Lemercier, C., Gilbert, D., and Fontaine, M., 1991, Evidence for an active hydrophobic form of factor H that is able to induce secretion of interleukin 1–ß or by human monocytes, Eur. J. Immunol. 21: 967–972.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ikeda, K., Sannoh, T., Kawasaki, N., Kawasaki, T., and Yamashina, I., 1987, Serum lectin with known structure activates complement through the classical pathway, J. Biol. Chem. 262: 7451–7454.

    PubMed  CAS  Google Scholar 

  • Isenman, D. E., 1983, Conformational changes accompanying proteolytic cleavage of human complement protein C3b by the regulatory enzyme factor I and its cofactor H, J. Biol. Chem. 258: 4238–4244.

    PubMed  CAS  Google Scholar 

  • Isenman, D. E., Kells, D. I. C., Cooper, N. R., Müller-Eberhard, H. J., and Pangburn, M. K., 1981, Nucleophilic modification of human complement protein C3: Correlation of conformational changes with acquisition of C3b-like functional properties, Biochemistry 20: 4458–4467.

    PubMed  CAS  CrossRef  Google Scholar 

  • Janatova, J., and Gobel, R. J., 1985, Activation and fragmentation of the third (C3) and the fourth (C4) components of complement: Generation and isolation of physiologically relevant fragments C3c and C4c, J. Immunol. Methods 85: 17–26.

    PubMed  CAS  CrossRef  Google Scholar 

  • Janatova, J., Reid, K. B. M., and Willis, A. C., 1987, Implications of disulfide bonds in the structure of C4b-binding protein, Complement 4: 173–174.

    Google Scholar 

  • Jensenius, J. C., Thiel, S., Baatrup, G., and Holmskov-Nielsen, U., 1985, Human conglutinin-like protein, Biosci. Rep. 5: 901–905.

    PubMed  CAS  CrossRef  Google Scholar 

  • Jeremiah, S. J., Abbott, C. M., Murad, Z., Povey, S., Thomas, H. J., Solomon, E., DiScipio, R. G., and Fey, G. H., 1990, The assignment of the genes coding for human complement components C6 and C7 to chromosome 5, Ann. Hum. Genet. 54: 141–147.

    PubMed  CAS  CrossRef  Google Scholar 

  • Jiang, H., Siegel, J. N., and Gewurz, H., 1991, Binding and complement activation by C-reactive protein via the collagen-like region of Clq and inhibition of these reactions by monoclonal antibodies to C-reactive protein and Clq, J. Immunol. 146: 2324–2330.

    Google Scholar 

  • Johnston, R. B., Jr., Lehmeyer, J. E., and Guthrie, L. A., 1976, Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G, J. Exp. Med. 143: 1551–1557.

    PubMed  CAS  CrossRef  Google Scholar 

  • Johnson, R. J., and Chenoweth, D. E., 1985, Labeling the granulocyte C5a receptor with a unique photoreactive probe, J. Biol. Chem. 260: 7161–7164.

    PubMed  CAS  Google Scholar 

  • Journet, A., and Tosi, M., 1986, Cloning and sequencing of full-length cDNA encoding the precursor of human complement component CI r, Biochem. J. 240: 783–787.

    PubMed  CAS  Google Scholar 

  • Kawasaki, N., Kawasaki, T., and Yamashina, I., 1985, Mannan-binding protein and conglutinin in bovine serum, J. Biochem. (Tokyo) 98: 1309–1320.

    CAS  Google Scholar 

  • Kawasaki, N., Kawasaki, T., and Yamashina, I., 1989, A serum lectin (mannan-binding protein) has complement-dependent bactericidal activity, J. Biochem. (Tokyo) 106: 483–489.

    CAS  Google Scholar 

  • Kay, A. B., and Austen, K. F., 1972, Chemotaxis of human basophil leucocytes, Clin. Exp. Immunol. 11: 557–563.

    PubMed  CAS  Google Scholar 

  • Kay, A. B., Shin, H. S., and Austen, K. F., 1973, Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylataxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a), Immunology 24: 969–976.

    PubMed  CAS  Google Scholar 

  • Kishimoto, T. K., O’Connor, K., Lee, A., Roberts, T. M., and Springer, T. A., 1987, Cloning of the ß subunit of the leukocyte adhesion proteins: Homology to an extracellular matrix receptor defines a novel supergene family, Cell 48: 681–690.

    PubMed  CAS  CrossRef  Google Scholar 

  • Klickstein, L. B., Wong, W. W., Smith, J. A., Weis, J. H., Wilson, J. G., and Fearon, D. T., 1987, Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristic of C3/C4 binding proteins, J. Exp. Med. 165: 1095–1112.

    PubMed  CAS  CrossRef  Google Scholar 

  • Klickstein, L. B., Bartow, T. J., Miletic, V., Rabson, L. D., Smith, J. A., and Fearon, D. T., 1988, Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis, J. Exp. Med. 168: 1699–1717.

    PubMed  CAS  CrossRef  Google Scholar 

  • Knobel, H. R., Villiger, W., and Isliker, H., 1975, Chemical analysis and electron microscopy studies of human Clq prepared by different methods, Eur. J. Immunol. 5: 78–82.

    PubMed  CAS  CrossRef  Google Scholar 

  • Krych, M., Hourcade, D., and Atkinson, J. P., 1991, Sites within the complement C3b/C4b receptor important for the specificity of ligand binding, Proc. Natl. Acad. Sci. USA 88: 4353–4357.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lad, P. M., Olson, C. V., and Smiley, P. A., 1985, Association of the N-formyl-Met-Leu-Phe receptor in human neutrophils with a GTP-binding protein sensitive to pertussis toxin, Proc. Natl. Acad. Sci. USA 82: 869–873.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lambris, J. D., and Ross, G. D., 1982, Characterisation of the lymphocyte membrane receptor for factor H (01H-globulin) with an antibody to anti-factor H idiotype, J. Exp. Med. 155: 1400–1411.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lanier, L. L., Arnaout, M. A., Schwarting, R., Warner, N. L., and Ross, G. D., 1985, p150/95, third member of the LFA-1 /CR3 polypeptide family identified by anti-Leu M5 monoclonal antibody, Eur. J. Immunol. 15: 713–718.

    Google Scholar 

  • Larson, R. S., and Springer, T. A., 1990, Structure and function of leukocyte integrins, Immunol. Rev. 114: 181–217.

    PubMed  CAS  CrossRef  Google Scholar 

  • Larson, R. S., Corbi, A. L., Berman, L., and Springer, T., 1989, Primary structure of the leukocyte function-associated molecule-1 alpha subunit: An integrin with an embedded domain defining a protein superfamily, J. Cell Biol. 108: 703–712.

    PubMed  CAS  CrossRef  Google Scholar 

  • Law, S. K. A., 1983, The covalent binding reaction of C3 and C4, Ann. N. Y. Acad. Sci. 421: 246–258.

    PubMed  CAS  CrossRef  Google Scholar 

  • Law, S. K. A., 1988, C3 receptors on macrophages, J. Cell Sci. Suppl. 9: 67–97.

    PubMed  CAS  Google Scholar 

  • Law, S. K., and Levine, R. P., 1977, Interaction between the third complement protein and cell surface macromolecules, Proc. Natl. Acad. Sci. USA 74: 2701–2705.

    PubMed  CAS  CrossRef  Google Scholar 

  • Law, S. K. A., and Reid, K. B. M., 1988, Complement (in In Focus series), IRL Press, Oxford, U.K. Law, S. K., Fearon, D. T., and Levine, R. P., 1979a, Action of the C3b-inactivator on cell-bound C3b, J. Immunol. 122: 759–765.

    Google Scholar 

  • Law, S. K. A., Lichtenberg, N. A., and Levine, R. P., 1979b, Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces, J. Immunol. 123: 1388–1394.

    PubMed  CAS  Google Scholar 

  • Law, S. K., Lichtenberg, N. A., Holcombe, F. H., and Levine, R. P., 1980, Interaction between the labile binding sites of the fourth (C4) and fifth (CS) human complement proteins and erythrocyte cell membranes, J. Immunol. 125: 634–639.

    PubMed  CAS  Google Scholar 

  • Law, S. K. A., Gagnon, J., Hildreth, J. E. K., Wells, C. E., Willis, A. C., and Wong, A. J., 1987, The primary structure of the 0–subunit of the cell surface adhesion glycoproteins LFA-1, CR3 and p150,95 and its relationship to the fibronectin receptor, EMBO J. 6: 915–919.

    PubMed  CAS  Google Scholar 

  • Lay, W. H., and Nussenzweig, V., 1968, Receptors for complement on leukocytes, J. Exp. Med. 128: 991–1010.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lee, Y. M., Leiby, K. R., Allar, J., Paris, K., Lerch, B., and Okarma, T. B., 1991, Primary structure of bovine conglutinin, a member of the C-type animal lectin family, J. Biol. Chem. 266: 2715–2723.

    PubMed  CAS  Google Scholar 

  • Leytus, S. P., Kurachi, K., Sakariassen, K. S., and Davie, E. W., 1986, Nucleotide sequence of the cDNA coding for human complement Clr, Biochemistry 25: 4855–4863.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lo, S. K., Detmers, P. A., Levin, S. M., and Wright, S. D., 1989a, Transient adhesion of neutrophils to endothelium, J. Exp. Med. 169: 1779–1793.

    PubMed  CAS  CrossRef  Google Scholar 

  • Lo, S. K., van Seventer, G. A., Levin, S. M., and Wright, S. D., 1989b, Two leukocyte receptors (CD’ la/ CD 18 and CD I 1 b/CD 18) mediate transient adhesion to endothelium by binding to different ligands, J. Immunol. 143: 3325–3329.

    PubMed  CAS  Google Scholar 

  • Loike, J. D., Sodeik, B., Cao, L., Leucona, S., Weitz, J. I., Detmers, P. A., Wright, S. D., and Silverstein, S. C., 1991, CD l lc/CD18 on neutrophils recognizes a domain at the N terminus of the Aa chain of fibrinogen, Proc. Natl. Acad. Sci. USA 88: 1044–1048.

    CAS  CrossRef  Google Scholar 

  • Lu, J., Thiel, S., Wiedemann, H., Timpl, R., and Reid, K. B. M., 1990, Binding of the pentamer/hexamer forms of mannan-binding protein to zymosan activates the proenzyme C1r2Cls2 complex, of the classical pathway of complement, without involvement of C iq, J. Immunol. 144: 2287–2294.

    PubMed  CAS  Google Scholar 

  • Lu, J., Willis, A. C., and Reid, K. B. M., 1992, Purification, characterisation and cDNA cloning of human lung surfactant protein D, Biochem. J., 284: 795–802.

    PubMed  CAS  Google Scholar 

  • Lu, Z. X., Fok, K. F., Erickson, B. W., and Hugli, T. E., 1984, Conformational analysis of COOH-terminal segments of human C3a. Evidence of ordered conformation in an active 21–residue peptide, J. Biol. Chem. 259: 7367–7370.

    PubMed  CAS  Google Scholar 

  • Lublin, D. M., Liszewski, M. K., Post, T. W., Arce, M. A., Le-Beau, M. M., Rebentisch, M. B., Lemons, L. S., Seya, T., and Atkinson, J. P., 1988, Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins, J. Exp. Med. 168: 181–194.

    PubMed  CAS  CrossRef  Google Scholar 

  • Malhotra, R., and Sim, R. B., 1989, Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent Clq, Biochem. J. 262: 625–631.

    PubMed  CAS  Google Scholar 

  • Malhotra, R., Thiel, S., Reid, K. B. M., and Sim, R. B., 1990, Human leukocyte C lq receptor binds other soluble proteins with collagen domains, J. Exp. Med. 172: 955–959.

    PubMed  CAS  CrossRef  Google Scholar 

  • Malhotra, R., Willis, A. C., and Sim, R. B., 1991, Structural characterisation of C lq receptor, Complement, and Inflammation 8: 188.

    Google Scholar 

  • Malhotra, V., Hogg, N., and Sim, R. B., 1986, Ligand binding by the p 150,95 antigen of U937 monocytic cells: Properties in common with complement receptor type 3 (CR3), Eur. J. Immunol. 16: 1117–1123.

    PubMed  CAS  CrossRef  Google Scholar 

  • Mantovani, B., Rabinovitch, M., and Nussenzweig, V., 1972, Phagocytosis of immune complexes by macrophages: Different roles of the macrophage receptor sites for complement (C3) and for immunoglobulin (IgG), J. Exp. Med. 135: 780–792.

    PubMed  CAS  CrossRef  Google Scholar 

  • Marlin, S. D., and Springer, T. A., 1987, Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1), Cell 51: 813–819.

    PubMed  CAS  CrossRef  Google Scholar 

  • Marlin, S. D., Morton, C. C., Anderson, D. C., and Springer, T. A., 1986, LFA-1 immunodeficiency disease—definition of the genetic defect and chromosomal mapping of a and ß subunits of the lymphocyte function associated antigen 1 (LFA-1) by complementation in hybrid cells, J. Exp. Med. 164: 855–867.

    PubMed  CAS  CrossRef  Google Scholar 

  • McCauliffe, D. P., Lux, F. A., Lieu, T. S., Sanz, I., Hanke, J., Newkirk, M. M., Bachinski, L. L., Itoh, Y., Siciliano, M. J., Reichlin, M., Sontheimer, D. D., and Capra, J. D., 1990, Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen, J. Clin. Invest. 85: 1379–1391.

    PubMed  CAS  CrossRef  Google Scholar 

  • Medof, M. E., and Oger, J. J. F., 1982, Competition for immune complexes by red cells in human blood, J. Lab. Clin. Immunol. 7: 7–13.

    CAS  Google Scholar 

  • Medof, M. E., Lublin, D. M., Holers, V. M., Ayers, D. J., Getty, R. R., Leykam, J. F., Atkinson, J. P., and Tykocinski, M. L., 1987, Cloning and characterization of cDNAs encoding the complete sequence of decay-accelerating factor of human complement, Proc. Natl. Acad. Sci. USA 84: 2007–2011.

    PubMed  CAS  CrossRef  Google Scholar 

  • Micklem, K. J., and Sim, R. B., 1985, Isolation of complement-fragment-iC3b binding proteins by affinity chromatography: The identification ofp 150,95 as an iC3b-binding protein, Biochem. J. 231: 233–236.

    PubMed  CAS  Google Scholar 

  • Miller, L. J., Bainton, D. F., Borregaard, N., and Springer, T. A., 1987, Stimulated mobilization of monocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface, J. Clin. Invest. 80: 535–544.

    PubMed  CAS  CrossRef  Google Scholar 

  • Moon, K. E., Gorski, J. P., and Hugli, T. E., 1981, Complete primary structure of human C4a anaphylatoxin, J. Biol. Chem. 256: 8685–8692.

    PubMed  CAS  Google Scholar 

  • Moore, M. D., Cooper, N. R., Tack, B. F., and Nemerow, G. R., 1987, Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes, Proc. Natl. Acad. Sci. USA 84: 9194–9198.

    PubMed  CAS  CrossRef  Google Scholar 

  • Morley, B. J., and Campbell, R. D., 1984, Internal homologies of the Ba fragment from human complement component factor B, a class III MHC antigen, EMBO J. 3: 153–157.

    PubMed  CAS  Google Scholar 

  • Morris, K. M., Goldberger, G., and Colten, H. R., 1982, Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line, Science 215: 399–400.

    PubMed  CAS  CrossRef  Google Scholar 

  • Müller-Eberhard, H. J., Dalmasso, A. P., and Calcott, M. A., 1966, The reaction mechanism of 01C-globulin (C’3) in immune hemolysis, J. Exp. Med. 124: 33–54.

    CrossRef  Google Scholar 

  • Myones, B. L., Dalzell, J. G., Hogg, N., and Ross, G. D., 1988, Neutrophil and monocyte cell surface p150,95 has iC3b-receptor (CR4) activity resembling CR3, J. Clin. Invest. 82: 640–651.

    PubMed  CAS  CrossRef  Google Scholar 

  • Nagasawa, S., Ichihara, C., and Stroud, R. M., 1980, Cleavage of C4b by C3b inactivator: Production of a nicked form of C4b, C4b’, as an intermediate cleavage product of C4b by C3b inactivator, J. Immunol. 125: 578–582.

    PubMed  CAS  Google Scholar 

  • Nehesheim, D. G., Edalji, R. P., Mollison, D. W., Greer, J., and Zuiderweg, R. P., 1988, Secondary structure of complement component C3a anaphylatoxins in solution as determined by NMR spectroscopy: Differences between crystal and solution conformations, Proc. Natl. Acad. Sci. USA 85: 5036–5040.

    CrossRef  Google Scholar 

  • Nermut, M. V., Green, N. M., Eason, P., Yamada, S S, and Yamada, K. M., 1988, Electron microscopy and structural model of human fibronectin receptor, EMBO J. 7: 4093–4099.

    PubMed  CAS  Google Scholar 

  • Newman, S. L., Mikus, L. K., and Tucci, M. A., 1991, Differential requirements for cellular cytoskeleton in human macrophage complement receptor-and Fc receptor-mediated phagocytosis, J. Immunol. 146: 967–974.

    PubMed  CAS  Google Scholar 

  • Nguyen, V. C., Tosi, M., Gross, M. S., Cohen-Haguenauer, O., Jegou-Foubert, C., de-Tand, M. F., Meo, T., and Frezal, J., 1988, Assignment of the complement serine protease genes C I r and C 1 s to chromosome 12 region 12p13, Hum. Genet. 78: 363–368.

    PubMed  CAS  CrossRef  Google Scholar 

  • Nicholson-Weller, A., Burge, J., Fearon, D. T., Weller, P. F., and Austen, K. F., 1982, Isolation of a human erythrocyte membrane glycoprotein with decay accelerating activity for C3 convertases of the complement system, J. Immunol. 129: 184–189.

    PubMed  CAS  Google Scholar 

  • Ninomiya, Y., Gordon, M., van der Rest, M., Schmid, T., Linsenmayer, T., and Olsen, B. R., 1986, The developmentally regulated type X collagen gene contains a long open reading frame without introns, J. Biol. Chem. 261: 5041–5050.

    PubMed  CAS  Google Scholar 

  • Norman, D. G., Barlow, P. N., Baron, M., Day, A. J., Sim, R. B., and Campbell, I. D., 1991, Three-dimensional structure of a complement control protein module in solution, J. Mol. Biol. 219: 717–725.

    PubMed  CAS  CrossRef  Google Scholar 

  • O’Flaherty, J. T., and Ward, P. A., 1978, Leukocyte aggregation induced by chemotactic factors, Inflammation 3: 177–194.

    PubMed  CrossRef  Google Scholar 

  • O’Flaherty, J. T., Kreutzer, D. L., and Ward, P. A., 1978, The influence of chemotactic factors on neutrophil adhesiveness, Inflammation 3: 37–48.

    PubMed  CrossRef  Google Scholar 

  • Ohta, M., Okada, M., Yamashina, I., and Kawasaki, T., 1990, The mechanism of carbohydrate mediated- complement activation by the serum mannan-binding protein, J. Biol. Chem. 265: 1980–1984.

    PubMed  CAS  Google Scholar 

  • Pangburn, M. K., 1986, The alternative pathway, in Immunobiology of the Complement System: An Introduction for Research and Clinical Medicine ( G. D. Ross, ed.), pp. 45–62, Academic Press, Orlando, Fla.

    Google Scholar 

  • Pangburn, M. K., Schreiber, R. D., and Müller-Eberhard, H. J., 1977, Human complement C3b inactiva-tor: Isolation, characterization, and demonstration of an absolute requirement for the serum protein 01H for cleavage of C3b and C4b in solution, J. Exp. Med. 146: 257–270.

    PubMed  CAS  CrossRef  Google Scholar 

  • Pardo-Manuel, F., Rey-Campos, J., Hillarp, A., Dahlbäck, B., and Rodriguez de Cordoba, S., 1990, Human genes for the a and ß chains of complement C4b-binding protein are closely linked in a head-totail arrangement, Proc. Natl. Acad. Sci. USA 87: 4529–4532.

    PubMed  CAS  CrossRef  Google Scholar 

  • Peerschke, E. 1. B., and Ghebrehiwet, B., 1988, Modulation of platelet responses to collagen by Clq receptors, J. Immunol. 144: 221–225.

    Google Scholar 

  • Peerschke, E. I. B., and Ghebrehiwet, B., 1990, Platelet Clq receptor interactions with collagen-and Clq-coated surfaces, J. Immunol. 145: 2984–2988.

    PubMed  CAS  Google Scholar 

  • Persson, A., Chang, D., and Crouch, E., 1990, Surfactant protein D is a divalent cation-dependent carbohydrate-binding protein, J. Biol. Chem. 265: 5755–5760.

    PubMed  CAS  Google Scholar 

  • Peters, M. G., Ambrus, J. L., and Fauci, A. S., 1988, The Bb fragment of complement factor B acts as a B cell growth factor, J. Exp. Med. 168: 1225–1235.

    PubMed  CAS  CrossRef  Google Scholar 

  • Polley, M. J., and Nachman, R. L., 1983, Human platelet activation by C3a and C3a des arg, J. Exp. Med. 158: 603–615.

    PubMed  CAS  CrossRef  Google Scholar 

  • Pommier, C. G., Inada, S., Fries, L. F., Takahashi, T., Frank, M. M., and Brown, E. J., 1983, Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes, J. Exp. Med. 157: 1844–1854.

    PubMed  CAS  CrossRef  Google Scholar 

  • Poncz, M., Eisman, R., Heidenreich, R., Silver, S. M., Vilaire, G., Surrey, S., Schwartz, E., and Bennett, J. S., 1987, Structure of the platelet membrane glycoprotein Ilb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors, J. Biol. Chem. 262: 8476–8482.

    PubMed  CAS  Google Scholar 

  • Possmayer, F., 1988, A proposed nomenclature for pulmonary surfactant-associated proteins, Am. Rev. Respir. Dis. 138: 990–998.

    PubMed  CAS  CrossRef  Google Scholar 

  • Reid, K. B. M., 1983, Proteins involved in the activation and control of the two pathways of human complement, Biochem. Soc. Trans. 11: 1–12.

    PubMed  CAS  Google Scholar 

  • Rey-Campos, J., Rubinstein, P., and Rodriguez de Cordoba, S., 1988, A physical map of the human regulator of complement activation gene cluster linking the complement genes CR 1, CR2, DAF, and C4BP, J. Exp. Med. 167: 664–669.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ripoche, J., Day, A. J., Harris, T. J. R., and Sim, R. B., 1988, The complete amino acid sequence of human complement factor H, Biochem. J. 249: 593–602.

    PubMed  CAS  Google Scholar 

  • Rodriguez de Cordoba, S., and Rubinstein, P., 1987, New alleles of C4–binding protein and factor H and further linkage data in the regulator of complement activation (RCA) gene cluster in man, Immunogenetics 25: 267–268.

    CrossRef  Google Scholar 

  • Rollins, T. E., and Springer, M. S., 1985, Identification of the polymorphonuclear leukocyte C5a receptor, J. Biol. Chem. 260: 7157–7160.

    PubMed  CAS  Google Scholar 

  • Rollins, T. E., Siciliano, S., Kobayashi, S., Cianciarulo, D. N., Bonilla-Argudo, V., Collier, K., and Springer, M. S., 1991, Purification of the active C5a receptor from human polymorphonuclear leukocytes as a receptor-G1 complex, Proc. Natl. Acad. Sci. USA 88: 971–975.

    PubMed  CAS  CrossRef  Google Scholar 

  • Rosen, H., and Law, S. K. A., 1989, The leukocyte cell surface receptor(s) for the iC3b product of complement, Curr. Top. Microbiol. Immunol. 153: 99–122.

    CrossRef  Google Scholar 

  • Ross, G. D., Newman, S L, Lambris, J. D., Devery-Pocius, J. E., Cain, J. A., and Lachmann, P. J., 1983, Generation of three different fragments of bound C3 with purified factor I or serum. II. Location of binding sites in the C3 fragments for factors B and H, complement receptors, and bovine conglutinin, J. Exp. Med. 158: 334–352.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ross, G. D., Cain, J. A., and Lachmann, P. J., 1985a, Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b, J. Immunol. 134: 3307–3315.

    PubMed  CAS  Google Scholar 

  • Ross, G. D., Thompson, R. A., Walport, M. J., Springer, T. A., Watson, J. V., Ward, R. H. R., Lida, J., Newman, S. L., Harrison, R. A., and Lachmann, P. J., 1985b, Characterization of patients with an increased susceptibility to bacterial infections and a genetic deficiency of leukocyte membrane complement receptor type 3 and the related membrane antigen LFA-1, Blood 66: 882–890.

    PubMed  CAS  Google Scholar 

  • Ross, G. D., Cain, J. A., Myones, B. L., Newman, S. L., and Lachmann, P. J., 1987, Specificity of membrane complement receptor type three (CR3) for beta-glucans, Complement 4: 61–74.

    PubMed  CAS  Google Scholar 

  • Rothlein, R., Dustin, M. L., Marlin, S. D., and Springer, T. A., 1986, A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1, J. Immunol. 137: 1270–1274.

    PubMed  CAS  Google Scholar 

  • Ruoslahti, E., 1991, Integrins, J. Clin. Invest. 87: 1–5.

    PubMed  CAS  CrossRef  Google Scholar 

  • Russell, D. G., and Wright, S. D., 1988, Complement receptor type 3 (CR3) binds to an Arg-Gly-Asp-containing region of the major surface glycoprotein, gp63, of leishmania promastigotes, J. Exp. Med. 168: 279–292.

    PubMed  CAS  CrossRef  Google Scholar 

  • Sanchez-Madrid, F., Nagy, J. A., Robbins, E., Simon, P., and Springer, T. A., 1983, A human leukocyte differentiation antigen family with distinct a-subunits and a common ß-subunit: The lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM 1 /Mac-1), and the p150,95 molecule, J. Exp. Med. 158: 1785–1803.

    PubMed  CAS  CrossRef  Google Scholar 

  • Schifferli, J. A., Ng, Y. C., Estreicher, J., and Walport, M. J., 1988, The clearance of tetanus toxoid/antitetanus toxoid immune complexes from the circulation of humans. Complement-and erythrocyte complement receptor 1–dependent mechanisms, J. Immunol. 140: 899–904.

    PubMed  CAS  Google Scholar 

  • Schlesinger, L. R., and Horwitz, M. A., 1991, Phagocytosis of Mycobacterium leprae by human monocyte-derived macrophages is mediated by complement receptors CR1 (CD35), CR3 (CD11b/CD18), and CR (CDI lc/CD18) and IFN-7 activation inhibits complement receptor function and phagocytosis of this bacterium, J. Immunol. 147: 1983–1994.

    PubMed  CAS  Google Scholar 

  • Schweinle, J. E., Ezekowitz, R. A., Tenner, A. J., Kuhlman, M., and Joiner, K. A., 1989, Human mannosebinding protein activates the alternative complement pathway and enhances serum bactericidal activity on a mannose-rich isolate of Salmonella, J. Clin. Invest. 84: 1821–1829.

    CAS  CrossRef  Google Scholar 

  • Sellar, G. C., Blake, D. J., and Reid, K. B. M., 1991, Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C l q. The complete derived amino acid sequence of human Clq, Biochem. J. 274: 481–490.

    PubMed  CAS  Google Scholar 

  • Seya, T., Turner, J., and Atkinson, J. P., 1986, Purification and characterization of membrane cofactor protein (MCP or gp 45–70) which is a cofactor for cleavage of C3b and C4b, J. Exp. Med. 163: 837–855.

    PubMed  CAS  CrossRef  Google Scholar 

  • Shiraishi, S, and Stroud, R. M., 1975, Cleavage products of C4b produced by enzymes in human serum, Immunochemistry 12: 935–939.

    PubMed  CAS  CrossRef  Google Scholar 

  • Shirato, M., Takahashi, K., Nagasawa, S., and Koyama, J, 1988, Different sensitivities of the responses of human neutrophils stimulated with immune complex and C5a anaphylatoxin to pertussis toxin, FEBS Lett. 234: 231–234.

    PubMed  CAS  CrossRef  Google Scholar 

  • Siciliano, S. J., Rollins, T. E., and Springer, M. S., 1990, Interaction between the C5a receptor and G; in both the membrane-bound and detergent-solubilized states, J. Biol. Chem. 265: 19568–19574.

    PubMed  CAS  Google Scholar 

  • Sim, E., Wood, A. B., Hsiung, L. M., and Sim, R. B., 1981, Pattern of degradation of human complement fragment C3b, FEBS Lett. 132: 55–60.

    PubMed  CAS  CrossRef  Google Scholar 

  • Sim, R. B., Arlaud, G. J., and Colomb, M. G., 1979, Cl inhibitor-dependent dissociation of human complement component CI bound to immune complexes, Biochem. J. 179: 449–457.

    PubMed  CAS  Google Scholar 

  • Simmons, D., Makgoba, M. W., and Seed, B., 1988, ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM, Nature (London) 331: 624–627.

    CAS  Google Scholar 

  • Smith, C. W., Marlin, S. D., Rothlein, R., Toman, C., and Anderson, D. C., 1989, Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro, J. Clin. Invest. 83: 2008–2017.

    CAS  CrossRef  Google Scholar 

  • Solomon, E., Palmer, R. W., Hing, S., and Law, S. K. A., 1988, Regional localization of CD18, the ß-subunit of the cell surface adhesion molecule LFA-1, on human chromosome 21 by in situ hybridization, Ann. Hum. Genet. 52: 123–128.

    PubMed  CAS  CrossRef  Google Scholar 

  • Springer, T., Galfré, G., Secher, D. S., and Milstein, C., 1979, Mac-1: A macrophage differentiation antigen identified by monoclonal antibody, Eur. J. Immunol. 9: 301–306.

    PubMed  CAS  CrossRef  Google Scholar 

  • Stacker, S. A., and Springer, T. A., 1991, Leukocyte integrin p150,95 (CD11c/CD18) functions as an adhesion molecule binding to a counter-receptor on stimulated endothelium, J. Immunol. 146: 648–655.

    PubMed  CAS  Google Scholar 

  • Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., and Springer, T. A., 1988, Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families, Cell 52: 925–933.

    PubMed  CAS  CrossRef  Google Scholar 

  • Staunton, D. E., Dustin, M. L., Erickson, H. P., and Springer, T. A., 1990, The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA- I and rhinovirus, Cell 61:243–254 [published erratum appears in Ce1161:1157].

    Google Scholar 

  • Symon, F. A., Anandavijayan, S., and Fothergill, J. E., 1991, A receptor for C3a on HL60 cells, Complement, and Inflammation 8: 228.

    Google Scholar 

  • Szebenyi, D. M. E., Obendorf, S. K., and Moffat, K., 1981, Structure of vitamin D dependent calcium-binding protein from bovine intestine, Nature (London) 294: 327–332.

    CAS  Google Scholar 

  • Tack, B. F., Harrison, R. A., Janatova, J., Thomas, M. L., and Prahl, J. W., 1980, Evidence for presence of an internal thioester bond in the third component of complement, Proc. Natl. Acad. Sci. USA 77: 5764–5768.

    PubMed  CAS  CrossRef  Google Scholar 

  • Takada, Y., and Hemler, M. E., 1989, The primary structure of the VLA-2/collagen receptor a2 subunit (platelet GPIa): Homology to other integrins and the presence of a possible collagen-binding domain, J. Cell Biol. 109: 397–407.

    PubMed  CAS  CrossRef  Google Scholar 

  • Talamas-Rohana, P., Wright, S. D., Lennartz, M. R., and Russell, D. G., 1990, Lipophosphoglycan from Leishmania mexicana promastigotes binds to members of the CR3, p150,95 and LFA-1 family of leukocyte integrins, J. Immunol. 144: 4817–4824.

    PubMed  CAS  Google Scholar 

  • Taniguchi-Sidle, A., and Isenman, D. E., 1992, Mutagenesis of the Arg-Gly-Asp (RGD) triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18), J. Biol. Chem. 267: 635–643.

    PubMed  CAS  Google Scholar 

  • Tenner, A. J., 1989, Clq interactions with cell surface receptors, Behring Inst. Mitt. 84:220–235. Tenner, A. J., and Cooper, N. R., 1980, Analysis of receptor-mediated Clq binding to human peripheral blood mononuclear cells, J. Immunol. 125: 1658–1664.

    Google Scholar 

  • Tenner, A. J., and Cooper, N. R., 1982, Stimulation of a human polymorphonuclear leukocyte oxidative response by the C lq subunit of the first complement component, J. Immunol. 128: 2547–2552.

    PubMed  CAS  Google Scholar 

  • Tenner, A. J., Robinson, S. L., Borchelt, J., and Wright, J. R., 1989, Human pulmonary surfactant protein (SP-A), a protein structurally homologous to Clq, can enhance FcR- and CR1–mediated phagocytosis, J. Biol. Chem. 264: 13923–13928.

    PubMed  CAS  Google Scholar 

  • Thiel, S., and Reid, K. B. M., 1989, Structures and functions associated with the group of mammalian lectins containing collagen-like sequences, FEBS Lett. 250: 78–84.

    PubMed  CAS  CrossRef  Google Scholar 

  • Todd, R. F., IIl, Arnaout, M. A., Rosin, R. E., Crowley, C. A., Peters, W. A., and Babior, B. M., 1984, Subcellular localization of the large subunit of Mo 1 (Mo 1 a; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion, J. Clin. Invest. 74: 1280–1290.

    CAS  Google Scholar 

  • Tosi, M., Duponchel, C., Meo, T., and Julier, C., 1987, Complete cDNA sequence of human complement C l s and close physical linkage of the homologous genes C I s and C 1 r, Biochemistry 26: 8516–8524.

    PubMed  CAS  CrossRef  Google Scholar 

  • van Dyne, S., Holers, V. M., Lublin, D. M., and Atkinson, J. P., 1987, The polymorphism of the C3b/C4b receptor in the normal population and in patients with systemic lupus erythematosus, Clin. Exp. Immunol. 68: 570–579.

    PubMed  Google Scholar 

  • Voss, T., Eistetter, H., Schafer, K. P., and Engel, J., 1988, Macromolecular organization of natural and recombinant lung surfactant protein SP 28–36. Structural homology with the complement factor C 1 q, J. Mol. Biol. 201: 219–227.

    PubMed  CAS  CrossRef  Google Scholar 

  • Voss, T., Melchers, K., Scheirle, G., and Schäfer, K. P., 1991, Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: Implications for the chain composition of natural human SP-A, Am. J Respir. Cell Mol. Biol. 4: 88–94.

    PubMed  CAS  CrossRef  Google Scholar 

  • Waxman, F. J., Herbert, L. A., Cornacoff, J. B., Vanaman, M. E., Smead, W. F., Kraut, E., Birmingham, D. J., and Taguiam, J. M., 1984, Complement depletion accelerates the clearance of immune complexes from the circulation of primates, J. Clin. Invest. 74: 1329–1340.

    PubMed  CAS  CrossRef  Google Scholar 

  • Weiler, J. M., Daha, M. R., Austen, K. F., and Fearon, D. T., 1976, Control of the amplification convertase of complement by the plasma protein ß1H, Proc. Natl. Acad. Sci. USA 73: 3268–3272.

    PubMed  CAS  CrossRef  Google Scholar 

  • Weis, J. H., Morton, C. C., Bruns, G. A. P., Weis, J. J., Klickstein, L. B., Wong, W. W., and Fearon, D. T., 1987, A complement receptor locus: Genes encoding C3b/C4b receptor and C3d/Epstein—Barr virus receptor map to 1q32, J. Immunol. 138: 312–315.

    PubMed  CAS  Google Scholar 

  • Weis, J. J., Tedder, T. F., and Fearon, D. T., 1984, Identification of a 145,000 M membrane protein as the C3d receptor (CR2) of human B lymphocytes, Proc. Natl. Acad. Sci. USA 81: 881–885.

    PubMed  CAS  CrossRef  Google Scholar 

  • Weis, J. J., Toothaker, L. E., Smith, J. A., Weis, J. H., and Fearon, D. T., 1988, Structure of the human B lymphocyte receptor for C3d and the Epstein—Barr virus and relatedness to other members of the family of C3/C4 binding proteins, J. Exp. Med. 167: 1047–1066 [published erratum appears in J. Exp. Med. 168:1953–1954].

    Google Scholar 

  • Weisman, H. F., Bartow, T., Leppo, M. K., Marsh, H. C. J., Carson, G. R., Concino, M. F., Boyle, M. P., Roux, K. H., Weisfeldt, M. L., and Fearon, D. T., 1990, Soluble human complement receptor type 1: In vivo inhibitor of complement suppressing post-ischemic myocardial inflammation and necrosis, Science 249: 146–151.

    PubMed  CAS  CrossRef  Google Scholar 

  • Weitkamp, L. R., and Lamm, L. U., 1982, Report of the committee on the genetic constitution of chromosome 6, Cytogenet. Cell Genet. 32: 130–143.

    PubMed  CAS  CrossRef  Google Scholar 

  • Weitzman, J. B., and Law, S. K. A., 1992, CR3 and its relationship with other phagocytic receptors, in Complement in Health and Disease, 2nd edition ( K. Whaley, ed.), pp. 265–293, Kluwar Academic Publishers, Lancaster.

    Google Scholar 

  • Weitzman, J. B., Wells, C. E., Wright, A. H., Clark, P. A., and Law, S. K. A., 1991, The gene organisation of the human ß2 integrin subunit (CD18), FEBS Leu. 294: 97–103.

    CAS  CrossRef  Google Scholar 

  • Whaley, K., and Ruddy, S., 1976, Modulation of C3b haemolytic activity by a plasma protein distinct from C3b-inactivator, Science 193: 1011–1013.

    PubMed  CAS  CrossRef  Google Scholar 

  • Whitehead, A. S., Solomon, E., Chambers, S., Bodmer, W. F., Povey, S., and Fey, G., 1982, Assignment of the structural gene for the third component of human complement to chromosome 19, Proc. Natl. Acad. Sci. USA 79: 5021–5025.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wilson, J. G., Murphy, E. E., Wong, W. W., Klickstein, L. B., Weis, J. H., and Fearon, D. T., 1986, Identification of a restriction fragment length polymorphism by a CR1 cDNA that correlates with the number of CR1 on erthyrocytes, J. Exp. Med. 164: 50–62.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wilson, J. G., Wong, W. W., Murphy, E. E., Schur, P. H., and Fearon, D. T., 1987, Deficiency of the C3b/C4b receptor (CR1) of erythrocytes in systemic lupus erythematosus: Analysis of the stability of the defect and of a restriction fragment length polymorphism of the CRI gene, J. Immunol. 138: 2706–2710.

    CAS  Google Scholar 

  • Wong, W. W., Wilson, J. G., and Fearon, D. T., 1983, Genetic regulation of a structural polymorphism of human C3b receptor, J. Clin. Invest. 72: 685–693.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., and Jong, M. T., 1986, Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide, J. Exp. Med. 164: 1876–1888.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., and Meyer, B. C., 1986, Phorbol esters cause sequential activation and deactivation of complement receptors on polymorphonuclear leukocytes, J. Immunol. 136: 1759–1764.

    PubMed  CAS  Google Scholar 

  • Wright, S. D., and Silverstein, S. C., 1982, Tumor-promoting phorbol esters stimulated C3b and C3b’ receptor-mediated phagocytosis in cultured human monocytes, J. Exp. Med. 156: 1149–1164.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., and Silverstein, S. C., 1983, Receptors for C3b and Cb3i promote phagocytosis but not the release of toxic oxygen from human phagocytes, J. Exp. Med. 158: 2016–2023.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Craigmyle, L. S., and Silverstein, S. C., 1983a, Fibronectin and serum amyloid P component stimulate C3b-and C3bi-mediated phagocytosis in cultured human monocytes, J. Exp. Med. 158: 1338–1343.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Rao, P. E., Van Voorhis, W. C., Craigmyle, L. S., Iida, K., Talle, M. A., Westberg, E. F., Goldstein, G., and Silverstein, S., 1983b, Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies, Proc. Natl. Acad. Sci. USA 80: 5699–5703.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Licht, M. R., Craigmyle, L. S., and Silverstein, S. C., 1984, Communication between receptors for different ligands on a single cell: Ligation of fibronectin receptors induces a reversible alteration in the function of complement receptors on cultured human monocytes, J. Cell Biol. 99: 336–339.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Detmers, P. A., Jong, M. T. C., and Meyer, B. C., 1986, Interferon-7 depresses binding of ligand by C3b and C3bi receptors on cultured human monocytes, an effect reversed by fibronectin, J. Exp. Med. 163: 1245–1259.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Reddy, P. A., Jong, M. T., and Erickson, B. W., 1987, C3bi receptor (complement receptor type 3) recognizes a region of complement protein C3 containing the sequence Arg-Gly-Asp, Proc. Natl. Acad. Sci. USA 84: 1965–1968.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Weitz, J. I., Huang, A. J., Levin, S. M., Silverstein, S. C., and Loike, J. D., 1988, Complement receptor type three (CD 11 b/CD 18) of human polymorphonuclear leukocytes recognizes fibrinogen, Proc. Natl. Acad. Sci. USA 85: 7734–7738.

    PubMed  CAS  CrossRef  Google Scholar 

  • Wright, S. D., Levin, S. M., Jong, M. T. C., Chad, Z., and Kabbash, L. G., 1989, CR3 (Cdl lb/CD18) expresses one binding site for Arg-Gly-Asp-containing peptides and a second site for bacterial lipopolysaccharide, J. Exp. Med. 169: 175–183.

    PubMed  CAS  CrossRef  Google Scholar 

  • Yamaguchi, N., Benya, P. D., van der Rest, M., and Nimomiya, Y., 1989, The cloning and sequencing of a1 (VIII) collagen cDNAs demonstrate that the type VIII collagen is a short chain collagen and contains triple helical and carboxyl-terminal non-triple-helical domains similar to those of type X collagen, J. Biol. Chem. 264: 16022–16029.

    PubMed  CAS  Google Scholar 

  • Yamamoto, K., and Johnston, R. B., Jr., 1984, Dissociation of phagocytosis from stimulation of the oxidative metabolic burst in macrophages, J. Exp. Med. 159: 405–416.

    PubMed  CAS  CrossRef  Google Scholar 

  • Ziccardi, R. J., and Cooper, N. R., 1979, Active disassembly of the first complement component, Cl, by Cl inactivator, J. Immunol. 123: 788–792.

    PubMed  CAS  Google Scholar 

  • Zohair, A., Chesne, S., Wade, R. H., and Colomb, M. G., 1989, Interaction between complement subcomponent Clq and bacterial lipopolysaccharides, Biochem. J. 257: 865–873.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK

    S. K. Alex Law

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  1. S. K. Alex Law
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  1. Imperial Cancer Research Fund Haemopoiesis Research Group, Department of Haematology, St. Bartholomew’s Hospital Medical College, EC1A 7BE, London, UK

    Michael A. Horton

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© 1993 Springer Science+Business Media New York

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Law, S.K.A. (1993). Complement Receptors. In: Horton, M.A. (eds) Macrophages and Related Cells. Blood Cell Biochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9534-9_9

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  • DOI: https://doi.org/10.1007/978-1-4757-9534-9_9

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