Macrophages and Related Cells

1. Front Matter

   Pages i-xix

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2. An Overview of Receptors of MPS Cells

   • Iain Fraser, Siamon Gordon

   Pages 1-27

3. Heterogeneity of Mononuclear Phagocytes

   • Pieter J. M. Leenen, Priscilla A. Campbell

   Pages 29-85

4. Origin of Macrophages

   • L. A. Ginsel

   Pages 87-113

5. Complement and the Mononuclear Phagocyte System

   • D. Lappin, K. Whaley

   Pages 115-148

6. Macrophages and Prostaglandins

   • John A. Hamilton

   Pages 149-159

7. Antigen Processing

   • Benjamin M. Chain, Timothy P. Levine

   Pages 161-182

8. Antigens of Osteoclasts Phenotypic Definition of a Specialized Hemopoietic Cell Lineage

   • M. H. Helfrich, M. A. Horton

   Pages 183-202

9. Electrophysiology of Osteoclasts and Macrophages

   • S. Jeffrey Dixon, Stuart A. Arkett, Stephen M. Sims

   Pages 203-222

10. Complement Receptors

    • S. K. Alex Law

    Pages 223-259

11. Fcγ Receptors of Myeloid Cells

    • M. de Haas, T. W. J. Huizinga, J. G. J. van de Winkel, D. Roos, A. E. G. Kr. von dem Borne

    Pages 261-277

12. Matrix Receptors of Myeloid Cells

    • Eric J. Brown, Frederik P. Lindberg

    Pages 279-306

13. Leukocyte Integrins

    • Ian Dransfield

    Pages 307-333

14. Molecular Basis for Leukocyte Adhesion Molecule Deficiency

    • M. Amin Arnaout

    Pages 335-346

15. Carbohydrate-Recognition Proteins of Macrophages and Related Cells

    • Maureen E. Taylor

    Pages 347-370

16. Leukocyte Adhesion to Endothelium

    • Martin H. Thornhill, Dorian O. Haskard

    Pages 371-392

17. Cell Recognition of Apoptotic Cells

    • Christopher A. Smith, Nicola J. McCarthy, Gwyn T. Williams

    Pages 393-421

18. Back Matter

    Pages 423-434

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To produce a comprehensive overview of macrophages and related cell types in a short review volume is an impossible task. When I selected the topics to be included, some equally important areas were omitted by necessity, and for this I apologize. My choices have been somewhat eclectic, touching subjects of personal interest (such as osteoclast biology and macrophage electrophysiology) or of current fashion (apopto­ sis, antigen processing, cell adhesion molecules). The book has also had to encompass areas of a more general flavor to provide balance for the general reader (such as reviews of macrophage development, heterogeneity, and function, and of the surface molecules expressed by macrophages). I thank all the authors for their prompt sub­ missions; all have been of high quality, and my editorial tasks, thankfully, have been minimal. Michael A. Horton London, United Kingdom ix Contents Chapter J An Overview of Receptors of MPS Cells lain Fraser and Siam on Gordon 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. The Mononuclear Phagocyte System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3. Diversity of Macrophage Plasma Membrane Receptors. . . . . . . . . . . . . . . . 6 3. 1 A Structural Approach to Classification . . . . . . . . . . . . . . . . . . . . . . . . . . 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 2 Multisubunit Receptors 3. 3 Soluble Receptors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 4 Lectins and Lectin-Like Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. Functions and Selected Examples. . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . 14 4. 1 Growth, Differentiation, and Modulation . . . . . . . . . . . . . . . . . . . . . . . . 14 4. 2 Cell-Cell and Cell-Matrix Interactions. . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 3 Endocytosis and Scavenger Receptors. . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 4. 4 Secretory Responses and Biosynthesis of Effector Molecules . . . . . . 17 5. Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 6. References. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 . . . . . . . . . . . . . . . . . . . .

• Antigen
• apoptosis
• biology
• cell
• macrophages
• physiology
• protein
• proteins
• receptor

• Imperial Cancer Research Fund Haemopoiesis Research Group, Department of Haematology, St. Bartholomew’s Hospital Medical College, London, UK

  Michael A. Horton

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