Fcγ Receptors of Myeloid Cells

  • M. de Haas
  • T. W. J. Huizinga
  • J. G. J. van de Winkel
  • D. Roos
  • A. E. G. Kr. von dem Borne
Part of the Blood Cell Biochemistry book series (BLBI, volume 5)


Fc receptors (FcRs) are cell surface molecules that mediate interactions between cells and immunoglobulins. Phagocytic cells, such as monocytes/macrophages, neutrophils, and eosinophils, need FcRs for the binding, ingestion, and destruction of particles opsonized by antibodies. The FcRs bind the Fc regions of immunoglobulins, thus establishing contact between the cell that carries FcRs on its surface and the antigen bound to the Fab region of the immunoglobulin.


Myeloid Cell Human Monocyte Human Neutrophil Toxoplasma Gondii Human Natural Killer Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Allen, J. M., and Seed, B., 1989, Isolation and expression of functional high-affinity Fc receptor complementary DNAs, Science 243: 378–380.PubMedCrossRefGoogle Scholar
  2. Anderson, P., Caliguiri, M., O’Brien, C., Manley, T., Ritz, J., and Schlossman, S. F., 1990a, Fey receptor type III (CD 16) is included in the NK receptor complex expressed by human natural killer cells, Proc. Natl. Acad. Sci. USA 87: 2274–2278.PubMedCrossRefGoogle Scholar
  3. Anderson, C. L., Shen, L., Eicher, D. M., Wevers, M. D., and Gill, J. K., I990b, Phagocytosis mediated by three distinct Fey receptor classes on human leukocytes, J. Exp. Med. 171: 1333–1343.Google Scholar
  4. Ashwell, J. D., and Klausner, R., 1990, Genetic and mutational analysis of the T cell antigen receptor, Annu. Rev. Immunol. 8: 139–142.PubMedCrossRefGoogle Scholar
  5. Bich-Tuy, L. T., Samarat, C., Brochier, J., and Revillard, J. P., 1981, Suppression of the late stages of mitogen-induced human B-cell differentiation by Fey receptors released from polynuclear neutrophils, J. Immunol. 127: 1299–1303.Google Scholar
  6. Bierling, P., Poulet, E., Fromont, P., Sereo, T., Bracq, C., and Duedari, N., 1990, Neutrophil-specific antigen and gene frequencies in the French population, Transfusion 30: 848–849.PubMedCrossRefGoogle Scholar
  7. Bonaficino, J. S., Suzuki, C. K., and Klausner, R. D., 1990a, A peptide sequence confers retention and rapid degradation in the endoplasmic reticulum, Science 247: 79–82.CrossRefGoogle Scholar
  8. Bonaficino, J. S., Cosson, P., and Klausner, R. D., 1990b, Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains, Cell 63: 503–513.CrossRefGoogle Scholar
  9. Boros, P., Odin, J. A., Muryoi, T., Masur, S. K., Bona, C., and Unkeless, J. C., 1991, IgM anti-FcyR autoantibodies trigger neutrophil degranulation, J. Exp. Med. 173: 1473–1482.PubMedCrossRefGoogle Scholar
  10. Brooks, D. G., Qiu, W. Q., Luster, A. D., and Ravetch, J. V., 1989, Structure and expression of human IgG FcyRII (CD23). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes, J. Exp. Med. 170: 1369–1385.PubMedCrossRefGoogle Scholar
  11. Burton, D. R., Jefferis, R., Partridge, L. J., and Woof, J. M., 1988, Molecular recognition of antibody (IgG) by cellular Fc receptor (FcRI), Mol. Immunol. 25: 1175–1181.PubMedCrossRefGoogle Scholar
  12. Cassatella, M. A., Anegon, I., Cuturi, M. C., Griskey, P., Trinchieri, G., and Perussia, B., 1989, FcyR (CD16) interaction with ligand induces CA mobilization and phosphoinositide turnover in human natural killer cells, J. Exp. Med. 169: 549–567.PubMedCrossRefGoogle Scholar
  13. Ceuppens, J. L., Baroja, M. L., van Vaeck, F., and Anderson, C. L., 1988, A defect in the membrane expression of high affinity 72 kD Fc receptors on phagocytic cells in four healthy subjects, J. Clin. Invest. 82: 571–575.PubMedCrossRefGoogle Scholar
  14. Clark, M. R., Liu, L., Clarkson, S. B., Ory, P. A., and Goldstein, I. M., 1990, An abnormality of the gene that encodes neutrophil Fc receptor III in a patient with systemic lupus erythematosus, J. Clin. Invest. 86: 341–346.PubMedCrossRefGoogle Scholar
  15. Clarkson, S. B., Bussel, J. B., Kimberly, R. P., Valinsky, J. E., Nachman, R. L., and Unkeless, J. C., 1986, Treatment of refractory immune thrombocytopenic purpura with an anti-Fey-receptor antibody, N. Engl. J. Med. 314: 1236–1239.PubMedCrossRefGoogle Scholar
  16. Clayton, L. K., D’Adamio, L., Howard, F. D., Sieh, M., Hussey, R. E., Koyasu, S., and Reinherz, E., 1991, CD3r1 and CD3– are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development, Proc. Natl. Acad. Sci. USA 88: 5202–5206.PubMedCrossRefGoogle Scholar
  17. Debets, J. M. H., van de Winkel, J. G. J., Ceuppens, J. L., Dieteren, I. E. M., and Buurman, W. A., 1990, Crosslinking of both FcyRI and FcyRII induces secretion of tumor necrosis factor by human monocytes, requiring high affinity Fc-FcyR interactions, J. Immunol. 144: 1304–1309.Google Scholar
  18. Duncan, A. R., Woof, J. M., Partridge, L. J., Burton, D. R., and Winter, G., 1988, Localization of the binding site for the human high affinity Fc receptor of IgG, Nature (London) 332: 563–565.Google Scholar
  19. Erbe, D. V., Collins, J. E., Shen, L., Graziano, R. F., and Fanger, M. W., 1990, The effect of cytokines on the expression of Fc receptors for IgG on human myeloid cells, Mol. Immunol. 27: 57–67.PubMedCrossRefGoogle Scholar
  20. Ernst, L. K., van de Winkel, J. G. J., Chiu, I. M., and Anderson, C. L., 1992, Three genes for the human high affinity Fc receptor for IgG (hFcyRI) encode four distinct transcription products, J. Biol. Chem. 267: 15692–15696.PubMedGoogle Scholar
  21. Fanger, M. W., Shen, L., Graziano, R. F., and Guyre, P. M., 1989, Cytotoxity mediated by human Fc receptors for lgG, Immunol. Today 10: 92–99.PubMedCrossRefGoogle Scholar
  22. Farber, D. L., and Sears, D. W., 1991, Rat CD16 is defined by a family of class III Fey receptors requiring co-expression of heteroprotein subunits, J. Immunol. 146: 4352–4361.PubMedGoogle Scholar
  23. Fitzharris, P., Cromwell, O., Moqbel, R., Hartnell, A., Walsh, G. M., Harvey, C., and Kay, A. B., 1987, Leukotriene B4 generation by human neutrophils following IgG-dependent stimulation, Immunology 61: 449–455.PubMedGoogle Scholar
  24. Frank, S. J., Niklinska, B. B., Orloff, D. G., Mercep, M., Ashwell, J. D., and Klausner, R. D., 1990, Structural mutations of the T cell receptor i“ chain and its role in T cell activation, Science 249: 174–177.PubMedCrossRefGoogle Scholar
  25. Fridman, W. H., Daeron, M., Amigorena, S., Rabourdin-Combe, C., and Néauport-Sautès, C., 1986, Basis for an isotypic network, Mol. Immunol. 23: 1141–1148.PubMedCrossRefGoogle Scholar
  26. Geisler, C., Kuhlman, J., and Rubin, B., 1989, Assembly, intracellular processing and expression at the cell surface of the human alfa beta T-cell receptor/CD3 complex, J. Immunol. 143: 4069–4077.PubMedGoogle Scholar
  27. Gregory, S. H., Magee, D. M., and Wing, E. J., 1991, The role of colony-stimulating factors in host defenses, Soc. Exp. Biol. Med. 1991: 349–357.Google Scholar
  28. Gresham, H. D., Clement, L. T., Volanakis, J. E., and Brown, E. J., 1987, Cholera toxin and pertussin toxin regulate Fc receptor mediated phagocytosic response of human neutrophils in a manner analogous to regulation by monoclonal AB 1C2, J. Immunol. 139: 4159–4166.PubMedGoogle Scholar
  29. Guyre, P. M., Morganelli, P. M., and Miller, R., 1983, Recombinant immune interferon increases immunoglobulin G Fc receptors on cultured human mononuclear phagocytes, J. Clin. Invest. 72: 393–397.PubMedCrossRefGoogle Scholar
  30. Guyre, P. M., Campbell, A. S., Kniffin, W. D., and Fanger, M. W., 1990, Monocytes and polymorphonuclear neutrophils of patients with streptococcal pharyngitis express increased numbers of type 1 IgG Fc receptors, J. Clin. Invest. 86: 1892–1896.PubMedCrossRefGoogle Scholar
  31. Harrison, D., Phillips, J. H., and Lanier, L. L., 1991, Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated FcyRIII (CD16–II), J. Immunol. 147: 3459–3465.PubMedGoogle Scholar
  32. Hibbs, M. L., Selveraj, P., Carpen, O., Springer, T. A., Kuster, H., Jouvin, M., and Kinet, J. P., 1989, Mechanisms for regulating expression of membrane isoforms of FcyRIII (CD16), Science 246: 1608–1611.PubMedCrossRefGoogle Scholar
  33. Huizinga, T. W. J., van der Schoot, C. E., Jost, C., Klaassen, R., Kleijer, M., von dem Borne, A. E. G., Roos, D., and Tetteroo P. A. T., 1988, The PI-linked receptor FcyRIII is released on stimulation of neutrophils, Nature (London) 333: 667–669.Google Scholar
  34. Huizinga, T. W. J., van Kemenade, F., Koenderman, L., Dolman, K. M., von dem Borne, A. E. G. Kr., Tetteroo, P. A. T., and Roos, D., 1989a, The 40–kD Fcy receptor (FcyRII) on human neutrophils is essential for the IgG-induced respiratory burst and IgG-induced phagocytosis, J. Immunol. 142: 2365–2369.PubMedGoogle Scholar
  35. Huizinga, T. W. J., Kerst, M., Nuijens, J. H., Vlug, A., and von dem Borne, A. E. G. Kr., 1989b, Binding characteristics of dimeric IgG subclass complexes to human neutrophils, J. Immunol. 142: 2359–2364.Google Scholar
  36. Huizinga, T. W. J., Kleijer, M., Tetteroo, P. A. T., Roos, D., and von dem Borne, A. E. G. Kr., 1990a, Biallelic neutrophil Na-antigen system is associated with a polymorphism on the phosphoinositollinked Fcy receptor III (CD 16), Blood 75: 213–217.Google Scholar
  37. Huizinga, T. W. J., Dolman, K. M., van der Linden, N. J. M., Kleijer, M., Nuijens, J. H., von dem Borne, A. E. G. Kr., and Roos, D., 1990b, Phosphatidyl inositol-linked FcRIII mediates exocytosis of neutrophil granule proteins, but does not mediate initiation of the respiratory burst, J. Immunol. 144: 1432–1436.Google Scholar
  38. Huizinga, T. W. J., Kuijpers, R. W. A. M., Kleijer, M., Schulpen, H. T., Roos, D., and von dem Borne, A. E. G., 1990c, Maternal neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia, Blood 76: 1927–1932.PubMedGoogle Scholar
  39. Huizinga, T. W. J., de Haas, M., Kleijer, M., Nuijens, J. H., Roos, D., and von dem Borne, A. E. G., 1990d, Soluble Fcy receptor III in human plasma originates from release by neutrophils, J. Clin. Invest. 86: 416–423.PubMedCrossRefGoogle Scholar
  40. Huizinga, T. W. J., van der Schoot, C. E., Roos, D., and Weening, R. S., 1991, Induction of neutrophil Fcy receptor I expression can be used as a marker for biological activity of recombinant interferon-y in vivo, Blood 77: 2088–2091.PubMedGoogle Scholar
  41. Jefferis, R., Lund, J., and Pound, J., 1990, Molecular definition of interaction sites on human IgG for Fc receptors (huFcyR), Mol. Immunol. 27: 1237–1240.PubMedCrossRefGoogle Scholar
  42. Jin, Y. J., Clayton, L. K., and Howard, F. D., 1990, Molecular cloning of the CD3 nu subunit identifies a CD3 zeta related produced in thymus derived cells, Proc. Natl. Acad. Sci. USA 87: 3319–3323.PubMedCrossRefGoogle Scholar
  43. Joiner, K. A., Fuhrman, S. A., Miettinen, H. M., Kasper, C. H., and Mellman, I., 1990, Toxoplasma gondii: Fusion competence of parasitophorous vacuoles in Fc receptor-transfected fibroblasts, Science 249: 641–646.Google Scholar
  44. Jost, C. R., Huizinga, T. W. J., de Goede, R., Fransen, J. A. M., Tetteroo, P. A. T., Daha, M. R., and Ginsel, L. A., 1990, Intercellular localisation and de novo synthesis of FcRIII in human neutrophil granulocytes, Blood 75: 144–151.PubMedGoogle Scholar
  45. Khayat, D., Geffrier, C., Yoon, S., Scigliano, E., Soubrane, C., Weil, M., Unkeless, J. C., and Jacquillat, C., 1987, Soluble circulating Fcy receptors in human serum. A new ELISA assay for specific and quantitative detection, J. Immunol. Methods 100: 235–241.PubMedCrossRefGoogle Scholar
  46. Klaassen, R. J. L., Ouwehand, W. H., Huizinga, T. W. J., Engelfriet, C. P., and von dem Borne, A. E. G. Kr., 1990, FcRIII on cultured human monocytes. Structural similarity with FcRIII on NK cells and role in the extracellular lysis of sensitized erythrocytes, I Immunol. 144: 599–606.Google Scholar
  47. Klausner, R. D., O’Shea, J. J., Luong, H., Ross, P., Bluestone, J. A., and Samelson, L. E., 1987, T cell receptor tyrosine phosphorylation, J. Biol. Chem. 262: 12654–12659.PubMedGoogle Scholar
  48. Koolwijk, P., van de Winkel, J. G. J., Pfefferkorn, L. C., Jacobs, C. W. M., Otten, I., Spierenburg, G. T., Bast, B. J. E. G., 1991, Induction of intracellular Cat+ mobilization and cytotoxicity by hybrid mouse monoclonal antibodies, J. Immunol. 147: 595–602.PubMedGoogle Scholar
  49. Kurosaki, T. S., and Ravetch, J. V., 1989, A single amino acid in the glycosyl phosphatidylinositol attachment domain determines the membrane topology of FcyRIII, Nature (London) 342: 805–807.Google Scholar
  50. Kurosaki, T., Gander, I., and Ravetch, J. V., 1991, A subunit common to an IgG Fc receptor and the T-cell receptor mediates assembly through different interactions, Proc. Natl. Acad. Sci. USA 88: 3837–3841.PubMedCrossRefGoogle Scholar
  51. Küster, H., Thompson, H., and Kinet, J. P., 1990, Characterization and expression of the gene for human Fc receptor gamma subunit. Definition of a new gene family, J. Biol. Chem. 265: 6448–6452.PubMedGoogle Scholar
  52. Lalezari, P., Khorshidi, M., and Petrosova, M., 1986, Autoimmune neutropenia of infancy, J. Pediatr. 109: 164–169.Google Scholar
  53. Lanier, L. L., Yu, G., and Phillips, J. H., 1989a, Co-association of CD3 with a receptor (CD16) for IgG Fc on human NK cells, Nature (London) 341: 159–162.Google Scholar
  54. Lanier, L. L., Cwirla, S., Yu, G., Testi, R., and Phillips, J. H., 1989b, Membrane anchoring ofa human IgG Fc receptor (CD16) determined by a single amino acid, Science 246: 1611–1613.PubMedCrossRefGoogle Scholar
  55. Lanier, L. L., Yu, G., and Phillips, J. H., 1991, Analysis of FcyRIII (CD16) membrane expression and association with CD3i-and FceRI-y by site-directed mutation, J. Immunol. 146: 1571–1576.PubMedGoogle Scholar
  56. Le Coniat, M., Kinet, J. P., and Berger, R., 1990, The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulins are located on human chromosome band Ig23, Immunogenetics 32: 183–186.PubMedCrossRefGoogle Scholar
  57. Letourneur, O., Kennedy, I. C. S., Brini, A. T., Ortaldo, J. R., O’Shea, J. J., and Kinet, J. P., 1991, Characterization of the family of dimers associated with Fc receptors (FceRI and FcyRIII), J. Immunol. 147: 2652–2656.PubMedGoogle Scholar
  58. Levy, P. C., Looney, R. J., Shen, L., Graziano, R. F., Fanger, M. W., Roberts, N. J., Ryan, D. H., and Utell, M. J., 1990, Human alveolar macrophage FcR-mediated cytotoxity: Heteroantibody versus conventional antibody-mediated target cell lysis, J. Immunol. 144: 3693–3700.PubMedGoogle Scholar
  59. Lund, J., Tanaka, T., Takahashi, N., Sarmay, G., Arata, Y., and Jefferis, R., 1990, A protein structural change in aglycosylated IgG3 correlates with loss of huFcyRI and huFcyRIII binding and/or activation, Mol. Immunol. 27: 1145–1153.PubMedCrossRefGoogle Scholar
  60. Lund, J., Winter, G., Jones, P. T., Pound, J. D., Tanaka, T., Walker, M. R., Artymiuk, P. J., Arata, Y., Burton, D. R., Jefferis, R., and Woof, J. M., 1991, Human FcyRI and FcyRII interact with distinct but overlapping sites on human IgG, J. Immunol. 147: 2657–2662.PubMedGoogle Scholar
  61. Lynch, R. G., Sandor, M., Waldschmidt, T. J., Mathur, A., Schaiff, W. T., Berg, D. J., Snapp, K., Mueller, A., Robinson, M. G., and Noben, N., 1990, Lymphocyte Fc receptors: Expression, regulation and function, Mol. Immunol. 27: 1167–1179.PubMedCrossRefGoogle Scholar
  62. Maurer, D., Fischer, G. F., Felzman, T., Majdic, O., Gaschwantler, E., Hinterberger, W., Wagner, A., and Knapp, W., 1991, Ratio of complement receptor over Fc-receptor III expression: A sensitive parameter to monitor granulocyte-macrophage colony-stimulating factor effects on neutrophils, Ann. Hematol. 62: 135–140.PubMedCrossRefGoogle Scholar
  63. Mendel, D. B., Shen, L., Guyre, P. M., 1988, The effect of tumor necrosis factor on three IgG Fc receptors of human neutrophils, Clin. Res. 35: 460–465.Google Scholar
  64. Mercep, M., Weissman, A. M., Frank, S. J., Klausner, R. D., and Ashwell, J. D., 1989, Activation driven programmed cell death and T cell receptor 07 expression, Science 246: 1162–1165.PubMedCrossRefGoogle Scholar
  65. Micklem, K. J., Stross, W. P., Willis, A. C., Cordell, J. L., Jones, M., and Mason, D. Y., 1990, Different isoforms of human FcRII distinguished by CDw23 antibodies, J. Immunol. 144: 2295–2303.PubMedGoogle Scholar
  66. Miettinen, H. M., Rose, J. K., and Mellman, I., 1989, Fc receptor isoforms exhibit distinct abilities for coated pit localisation as a result of cytoplasmic domain heterogenity, Cell 58: 317–327.PubMedCrossRefGoogle Scholar
  67. Newman, S. L., and Tucci, M. A., 1990, Regulation of human monocyte/macrophage functions by extra-cellular matrix. Adherence of monocytes to collagen matrices enhances phagocytosis of opsonized bacteris by activation of complement receptors and enhancement of Fc receptor function, J. Clin. Invest. 86: 703–714.PubMedCrossRefGoogle Scholar
  68. Nose, M., Takano, R., Nakamura, S., Arata, Y., and Kyogoku, M., 1990, Recombinant Fc of human IgG 1 prepared in an Escherichia coli system escapes recognition by macrophages, Int. Immunol. 2: 1109–1112.PubMedCrossRefGoogle Scholar
  69. Ohno, H., Saito, T., 1990, CD3 zeta and eta chains are produced by alternative splicing from a common gene, Int. Immunol. 2: 1117–1119.PubMedCrossRefGoogle Scholar
  70. Ohto, H., and Matso, Y., 1989, Neutrophil specific antigens and gene frequencies in Japanese population, Transfusion 29: 654–655.PubMedCrossRefGoogle Scholar
  71. Orloff, D. G., Ra, C., Frank, S. J., Klausner, R. D., and Kinet, J. P., 1990, Family of disulphide-linked dimers containing the 3’ and n chains of T-cell receptor and the chain of Fc receptors, Nature (London) 347: 189–191.Google Scholar
  72. O’Shea, J. J., Weissman, A. M., Kennedy, I. C., and Ortaldo, J. R., 1991, Engagement of the natural killer cell IgG Fc receptor results in tyrosine phosphorylation of the chain, Proc. Natl. Acad. Sci. USA 88: 350–354.PubMedCrossRefGoogle Scholar
  73. Parren, P. W. H. I., Warmerdam, P. A. M., Boeije, L. C. M., Arts, J., Westerwaal, N. A. C., Vlug, A., Capel, P. J. A., Aarden, L. A., and van de Winkel, J. G. J., 1992, On the interaction of IgG subclasses with the low-affinity FcyRIIa (CD32) on human monocytes, neutrophils and platelets: Analysis of a functional polymorphism to human IgG2, J. Clin. Invest. 90: 1537–1546.PubMedCrossRefGoogle Scholar
  74. Peitz, G., Frederick, K., Anderson, C. L., Peterlin, B. M., 1988, Characterization of the human monocyte high affinity Fc receptor (huFcRI), Mol. Immunol. 25: 243–250.CrossRefGoogle Scholar
  75. Perussia, B. E., Dayton, T., Lazarus, R., Fanig, V., and Trinchier, G., 1983, Immune interferon induces the receptor for monomeric IgGI on human monocytic and myeloid cells, J. Exp. Med. 158: 1092–1113.PubMedCrossRefGoogle Scholar
  76. Phillips, J. H., Chang, C., and Lanier, L. L., 1991, Platelet-induced expression of FcyRIII (CD16) on human monocytes, Eur. J. Immunol. 21: 895–899.PubMedCrossRefGoogle Scholar
  77. Qiu, W. Q., de Bruin, D., Brownstein, B. H., Pearse, R., and Ravetch, J. V., 1990, Organization of the human and mouse low affinity FcyR genes: Duplication and recombination, Science 248: 732–735.PubMedCrossRefGoogle Scholar
  78. Ravetch, J. V., and Anderson, C. L., 1990, FcyR-family: Proteins, transcripts and genes, in Fc-Receptors and Actions of Antibodies ( H. Metzger, ed.), pp. 211–235, ASM, Washington, D.C.Google Scholar
  79. Ravetch, J. V., and Perussia, B. V., 1989, Alternative membrane forms of FcRIII (CD16) on human natural killer cells and neutrophils, J. Exp. Med. 170: 481–489.PubMedCrossRefGoogle Scholar
  80. Repp, R., Valerius, T., Sendler, A., Gramatzki, M, Iro, H., Kalden, J. R., and Platzer, E., 1991, Neutrophils express the high affinity receptor for IgG (FcRRI, CD64) after in vivo application of recombinant human granulocyte colony stimulating factor, Blood 78: 885–889.PubMedGoogle Scholar
  81. Salmon, J. E., Edberg, J. C., Kimberley, R. P., Mensa, E., and Ryan, R., 1990, Fcy receptor III on human neutrophils. Allelic variants have functionally distinct capacities, J. Clin. Invest. 85: 1287–1295.PubMedCrossRefGoogle Scholar
  82. Sarmay, G., Jefferis, R., Klein, E., Benzcur, M., and Gergely, J., 1985, Mapping the functional topography of Fe gamma with monoclonal antibodies: Localization of epitopes interacting with the binding sites of Fc receptor on human K cells, Eur. J. Immunol. 15: 1037–1042.PubMedCrossRefGoogle Scholar
  83. Sautes, C., Varin, N., Teilland, C., Dâeron, M., Even, J., Hogarth, P. M., Fridman, W. H., 1991, Soluble Fey receptors II (FcyRII) are generated by cleavage of membrane FcyRII, Eur. J. Immunol. 21: 231–234.PubMedCrossRefGoogle Scholar
  84. Scallon, B. J., Scigliano, E., Fridman, V. H., Miedel, M. C., Pan, Y., and Unkeless, C. E., 1989, A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms, Proc. Natl. Acad. Sci USA 86: 5079–5083.PubMedCrossRefGoogle Scholar
  85. Selveraj, P., Rosse, W. F., Silber, R., and Springer, T. A., 1988, The major Fc receptor in blood has a phosphatidylinositol anchor and is deficient in paroxysmal nocturnal haemoglobinuria, Nature 333: 565–567.CrossRefGoogle Scholar
  86. Shen, L., Guyre, P. M., and Fanger, M., 1987, Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG, J. Immunol. 139: 534–538.PubMedGoogle Scholar
  87. Stroncek, D. F., Skubitz, K. M., Plachta, L. B., Shankar, R. A., Clay, M. E., Herman, J., Fleit, H. B., and McCullough, J., 1991, Alloimmune neonatal neutropenia due to an antibody to the neutrophil Fc-y receptor III with maternal deficiency of CD16 antigen, Blood 77: 1572–1580.PubMedGoogle Scholar
  88. Sussman, J. J., Bonifacino, J. S., Lippincott-Schwarz, J., Weissman, A. M., Saito, T., Klausner, R. D., and Ashwell, Y. D., 1988, Failure to synthesize the T cell CD3–chain: Structure and function of a partial T-cell receptor complex, Cell 52: 85–95.PubMedCrossRefGoogle Scholar
  89. to Velde, A. A., Huijbens, R. J. F., De Vries, J. E., and Figdor, C. G., 1990, I1–4 decreases FcyR membrane expression and Fe-yR mediated cytotoxive activation of human monocytes, J. Immunol. 144: 3046–3050.Google Scholar
  90. Ting, A. T., Einspahr, K. J., Abraham, R. T., and Leibson, P. J., 1991, Fcy receptor signal transduction in natural killer cells. Coupling to phospholipase C via a G-protein-independent, but tyrosine kinase-dependent pathway, J. Immunol. 147: 3122–3127.PubMedGoogle Scholar
  91. Trezzini, C., Jungi, T. W., Spycher, M. O., Maly, F. E., Raos, P., 1990, Human monocytes CD36 and CDI6 are signaling molecules. Evidence from studies using antibody-induced chemiluminescence as a tool to probe signal transduction, Immunology 71: 29–37.PubMedGoogle Scholar
  92. Trounstine, M. L., Feltz, G. A., Yssel, H., Huizinga, T. W. J., von dem Borne, A. E. G. Kr., Spits, H., and Moore, K. W., 1990, Reactivity of cloned expressed human FcRIII isoforms with monoclonal antibodies which distinguish cell-type specific and allelic forms of FcRIII, Int. Immunol. 2: 303–310.Google Scholar
  93. Tuijnman, W. B., Capel, P. J. A., and van de Winkel, J. G. J., 1992, Human low affinity IgG receptor FcyRIIa (CD32) introduced into mouse fibroblasts mediates phagocytosis of sensitized erythrocytes, Blood 79: 1–3.Google Scholar
  94. Van de Winkel, J. G. J., and Anderson, C. L., 1991, Biology and human immunoglobulin G Fc receptors, J. Leukocyte Biol. 49: 511–524.PubMedGoogle Scholar
  95. Van de Winkel, J. G. J., van Ommen, R., Huizinga, T. W. J., de Raad, M. A. H. V. M., Tuijnman, W. B., Groenen, P. J. T. A., Capel, P. J. A., Koene, R. A. P., and Tax, W. J. M., 1989, Proteolysis induces increased binding affinity of the monocyte type II FcR for human IgG, J. Immunol. 143: 571–578.PubMedGoogle Scholar
  96. Van de Winkel, J. G. J., Ernst, L. K., Anderson, C. L., and Chiu, I. M., 1991, Gene organization of the human high-affinity receptor for IgG, FcyRI (CD64), J. Biol. Chem. 266: 13449–13455.PubMedGoogle Scholar
  97. Varin-Blank, N., and Metzger, H., 1990, Surface expression of mutated subunits of the high affinity mast cell receptor for IgE, J. Biol. Chem. 265: 15684–15694.Google Scholar
  98. Vivier, E., Morin, P., O’Brien, C., Druker, B., Schlossman, S. F., and Anderson, P., 1991, Tyrosine phosphorylation of the FcyRIII(CD16M- complex in human natural killer cells, J. Immunol. 146: 206–210.PubMedGoogle Scholar
  99. Walker, M. R., Lund, J., Thompson, K. M., and Jefferis, R., 1989, Aglycosylation of human IgG1 and IgG3 monoclonal antibodies can eliminate recognition by human cells expressing FcyRI and/or FcyRlI, Biochem. J. 259: 347–353.PubMedGoogle Scholar
  100. Warmerdam, P. A. M., van de Winkel, J. G. J., Gosselin, E. J., and Capel, P. J. A., 1990, Molecular basis for a polymorphism of human Fc-y receptor II (CD32), J. Exp. Med. 172: 19–25.PubMedCrossRefGoogle Scholar
  101. Weissman, A. M., Hou, D., Orloff, D. G., Modi, W. S., Secranez, H., O’Brien, S. J., and Klausner, R. D., 1988, Molecular cloning and chromosomal localization of the human T-cell receptor zeta chain: Distinction from the CD3 complex. Proc. Natl. Acad. Sci. USA 85: 9709–9713.PubMedCrossRefGoogle Scholar
  102. Welch, G. R., Wong, H. L., and Wahl, S. M., 1990, Selective induction of FcyRIII on human monocytes by transforming growth factor-ß, J. Immunol. 144: 3444–3448.PubMedGoogle Scholar
  103. Wong, H. L., Welch, G. R., Brandes, M. E., and Wahl, S. M., 1991, Il-4 antagonizes induction of FcyRIII (CD16) expression by transforming growth factor-0 on human monocytes, J. Immunol. 147: 1843–1848.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • M. de Haas
    • 1
  • T. W. J. Huizinga
    • 2
  • J. G. J. van de Winkel
    • 3
  • D. Roos
    • 1
  • A. E. G. Kr. von dem Borne
    • 4
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical ImmunologyUniversity of AmsterdamAmsterdamThe Netherlands
  2. 2.Department of Internal MedicineRegional Hospital HilversumHilversumThe Netherlands
  3. 3.Department of ImmunologyUniversity Hospital UtrechtUtrechtThe Netherlands
  4. 4.Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Department of Hematology of the Academic Medical CentreAmsterdamThe Netherlands

Personalised recommendations