Molecular Packing in Collagen Fibrils

  • A. Miller


In this chapter I will discuss the three-dimensional arrangement of collagen molecules in the fibrils of connective tissue. This is a problem of quite general significance since the nature of the molecular packing in similar systems such as the fibrils of muscles and other biological fibers is still unknown. Once the sequence and symmetry of the individual collagen molecules are known, it is natural to proceed to inquire how these molecules aggregate to form the functional units of connective tissue. As Crick (1966) recognized, “the superlattice of collagen is a neglected problem and it is time somebody took it up again.”


Collagen Fibril Molecular Packing Collagen Molecule Heuristic Model Molecular Arrangement 
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© Springer Science+Business Media New York 1976

Authors and Affiliations

  • A. Miller
    • 1
  1. 1.Laboratory of Molecular Biophysics, Zoology DepartmentOxford UniversityOxfordEngland

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