Biochemistry of Collagen

1. Front Matter

   Pages i-xv

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2. Primary Structure

   • Karl. A. Piez

   Pages 1-44

3. Molecular Structure

   • G. N. Ramachandran, C. Ramakrishnan

   Pages 45-84

4. Molecular Packing in Collagen Fibrils

   • A. Miller

   Pages 85-136

5. Cross-Linking

   • Marvin Lawrence Tanzer

   Pages 137-162

6. Intracellular Steps in the Biosynthesis of Collagen

   • Darwin J. Prockop, Richard A. Berg, Kari I. Kivirikko, Jouni Uitto

   Pages 163-273

7. Aspects of the Animal Collagenases

   • Jerome Gross

   Pages 275-317

8. Immunological Studies on Collagen

   • Rupert Timpl

   Pages 319-375

9. Collagen Pathology at the Molecular Level

   • Charles M. Lapière, Betty Nusgens

   Pages 377-447

10. Collagen and Cell Differentiation

    • A. H. Reddi

    Pages 449-478

11. Synthetic Polypeptide Models of Collagen: Synthesis and Applications

    • Rajendra S. Bhatnagar, Rao S. Rapaka

    Pages 479-523

12. Back Matter

    Pages 525-536

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Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi­ cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo­ gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama­ krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow­ ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.

• biochemistry
• chemistry
• primary structure
• protein
• synthesis

• Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

  G. N. Ramachandran

• The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, USA

  A. H. Reddi

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