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Primary Structure

  • Chapter
Biochemistry of Collagen

Abstract

The primary structure of a protein is defined as the sequence of the amino acid residues in its polypeptide chain(s). This definition will be expanded here to include all covalent structures such as cross-links, attached carbohydrates, and modifications to amino acid side chains. However, it should be remembered that the sequence of amino acids in α-amino peptide linkage is the product of a structural gene, while all other aspects of covalent structure result from posttranslational events. Thse two aspects of covalent structure require that two quite different concepts be invoked in understanding the biological regulation of structure—function relationships.

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Authors and Affiliations

  1. Laboratory of Biochemistry, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, 20014, USA

    Karl. A. Piez

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  1. Karl. A. Piez
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Editors and Affiliations

  1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

    G. N. Ramachandran

  2. The Ben May Laboratory for Cancer Research, University of Chicago, Chicago, Illinois, USA

    A. H. Reddi

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Piez, K.A. (1976). Primary Structure. In: Ramachandran, G.N., Reddi, A.H. (eds) Biochemistry of Collagen. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4602-0_1

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  • DOI: https://doi.org/10.1007/978-1-4757-4602-0_1

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