Abstract
Several analytical methods based on adiabatic reaction calorimetry have been developed in recent years. Authoritative reviews of thermometric enthalpy titrations (including kinetic titrimetry), direct injection enthalpimetry and thermokinetic analysis are available.1–8 Applications to biochemical and clinical analysis8–20 have thus far been sporadic notwithstanding the fact that these fields are in dire need of instrumental methods. The relevant fundamental phenomenon (enthalpy change) is universal for all chemical reactions including biochemically and clinically important processes. Successful studies of biologically significant oxidation-reductions by titration calorimetry are reported in this paper. A new method, called “peak enthalpimetry,” is described and assessed in the context of contemporary requirements for instrumental approaches to clinical analysis. The use of novel Curie point temperature sensors for immunological determinations is discussed.
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References Cited
L.S. Bark, S.M. Bark, Thermometric Titrimetry, Pergamon Press, Oxford, 1969.
L.S. Bark, P. Bate, J.K. Grime, “Thermometric and Enthalpimetric Titrimetry” in Selected Annual Reviews of the Analytical Society, Vol. II (L.S. Bark, Ed.) Society for Analytical Chemistry, London, 1972, pp. 121–149.
P.W. Carr, Crit. Rev. of Anal. Chem., 3, 491 (1972).
R. M. Izatt, J.J. Christensen, “Thermochemistry in Inorganic Solution Chemistry,” in Physical Methods in Advanced Inorganic Chemistry, H.A.O. Hill, P. Day, Eds., Interscience, New York, 1968, Chap. 11, pp. 538–598.
J. Jordan, “Thermometric Enthalpy Titrations” in Treatise in Analytical Chemistry, I.M. Kolthoff, P.J. Elving, Eds., Part I, Vol. 8, Interscience, New York, 1968, pp. 5175–5242.
J. Jordan, in Topics in Chemical Instrumentation, G. W. Ewing, Ed., Chemical Education Publ. Co., Easton, Pa., 1971, pp. 193–199.
H. J. V. Tyrell, A. E. Beezer, Thermometric Titrimetry, Chapman and Hall, London, 1968.
J. Jordan, N.D. Jespersen, Coll. Int. Cent. Nat. Rech. Sci., 201, 59 (1972).
E. B. Smith, P. W. Carr, Anal. Chem., In Press (1974).
J.J. Christensen, R.M. Izatt, D.P. Wrathall, L. Hansen, J. Chem. Soc. A., 1212 (1969).
J.J. Christensen, J.L. Oscarson, R.M. Izatt, J. Am. Chem. Soc, 90, 5949 (1968).
J.J. Christensen, J.H. Rytting, R.M. Izatt, Biochemistry, 9 , 4907 (1970).
J.J. Christensen, J.H. Rytting, R.M. Izatt, J. Chem. Soc. B., 1643 (1970).
J.J. Christensen, J.H. Rytting, R.M. Izatt, J. Chem. Soc. B., 1646 (1970).
J.J. Christensen, M.D. Slade, D.M. Smith, R.M. Izatt, J. Tsang, J. Am. Chem. Soc, 92, 4164 (1970).
R.M. Izatt, J.J. Christensen, J.H. Rytting, Chem. Rev., 71, 439 (1971).
R.M. Izatt, J.J. Christensen, Handbook of Biochemistry, H.A. Sober, Ed., Chemical Rubber Co., Cleveland, 1968, np.J-49.
N.D. Jespersen, J. Jordan, Anal. Letters, 3, 323 (1970).
M.A. Marini, R.L. Berger, D.P. Lan, C.J. Martin, Anal. Biochem., 43, 188 (1971).
B. Sen, W.C. Wu, Anal. Chim. Acta, 2, 457 (1971).
R.J. Thompson, Thesis in Progress, Pennsylvania State University.
D.H. Waugh, Thesis in Progress, Pennsylvania State University.
P. Priestley, W. Sebborn, R. Selman, Analyst, 90, 598 (1965).
W. McLean, G. Penketh, Talanta, 15, 1185 (1968).
T. Crompton, B. Cope, Anal. Chem., 40 , 274 (1968).
H. Yoshida, M. Taga, S. Hikime, Japan Analyst, 20 , 361 (1971).
J.G. Montalvo, D.G. Davis, J. Electroanal. Chem., 23, 164 (1969).
A.C. Censullo, Thesis in Progress, Pennsylvania State University
M.L. McGlashan, Pure and Appl. Chem., 21, 3 (1970).
W. Mansfield Clark, Oxidation-Reduction Potentials of Organic Systems, Williams and Wilkins Co., Baltimore, 1960, p. 318.
Lowell J. Reed, J. Berkson, J. Phys. Chem., 33, 760 (1929).
S.J. Ashcroft, CT. Mortimer, Thermochemistry of Transition Metal Complexes, Academic Press, New York, 1970, p. 276.
O. Schales, S. Schales, J. Biol. Chem., 140, 879 (1941).
R.J.P. Williams, J. Phys. Chem., 58, 121 (1954).
T.M. Bednarski, J. Jordan, J. Am. Chem. Soc, 89, 1552 (1967).
C. K. Chang, T.G. Traylor, J. Am. Chem. Soc, 95, 5810 (1973).
CK. Chang, T.G. Traylor, Proc. Nat. Acad. Sci. U.S.A., 70, 2647 (1973).
J.E. Baldwin, Joel Huff, J. Am. Chem. Soc, 95, 5757 (1973).
N.D. Jespersen, Thesis, Pennsylvania State University, 1971.
J.A. Lynch, Thesis in Progress, Pennsylvania State University.
J.A. Lynch, J. Jordan, Abstracts, 25th Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Cleveland, 1974, Paper #54.
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Censullo, A.C., Lynch, J.A., Waugh, D.H., Jordan, J. (1974). Biochemical and Clinical Applications of Titration Calorimetry and Enthalpimetric Analysis. In: Porter, R.S., Johnson, J.F. (eds) Analytical Calorimetry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4509-2_18
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DOI: https://doi.org/10.1007/978-1-4757-4509-2_18
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