Abstract
N-(3,5-dichlorophenyl) succimide (NDPS) was developed as an agricultural fungicide during the early 1970s (Fujinami et al, 1972). Although preliminary field testing of NDPS was promising, the usefulness of NDPS as an agricultural fungicide has been limited because of potential toxicity. NDPS has been shown to produce tubular necrosis following acute exposure which is characterized by diuresis, proteinuria, glucosuria, haematuria, increased blood urea nitrogen (BUN) concentration and kidney weight, and decreased organic ion accumulation by renal cortical slices (Rankin, 1982; Rankin et al. , 1985). Chronic exposure to NDPS produces interstitial nephritis (Sugihara et al. , 1975). In addition, NDPS has been shown to promote the activity of several renal carcinogens including the nitrosamines (Ito et al, 197 4) and citrinin (Shinohara et al. , 1976).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fujinami, A., Ozaki, T., Nodera, K., and Tanaka, K., 1972, Studies on biological activity of cyclic imide compounds. Part II. Antimicrobial activity of 1-phenylpyrrolidine-2,5- diones and relates compounds, Agric. Biol. Chem., 36: 318.
Ito, N. , Sugihara, S. , Makiura, S. , Arai, M. , Hirao, K. , Denda, S. , and Nishio, O., 1974, Effect of N-(3,5-dichlorophenyl) succinimide on the histological pattern and incidence of kidney tumors in rats induced by dimenthylnitrosamine, Gann, 65:131.
Ohkawa, H. , Hisada, Y. , Fujiwara, N. , and Miyamoto, J., 1974, Metabolism of N-(3,5-dichlorophenyl) succinimide in rats and dogs, Aggric. Biol. Chem., 7:1359.
Rankin, G.O., 1982, Nephrotoxicity following acute administration of N(3, 5-dichlorophenyl) succinimide in Sprague-Dawley rats, Toxicology, 23: 21.
Rankin, G.O. , Yang, D.J. , Cressey-Veneziano, K. , and Brown, P.I., 1985, N-(3,5-Dichlorophenyl) succinimide nephrotoxicity in the Fischer 344 rat, Toxicol. Lett., 24:99
Rankin, G.O. , Yang, D.J. , Richmond, C.D. , Teets, V.J. , Wang, R. I. and Brown, P. I., 1987a, Effect of microsomal enzyme activity modulation on N(3,5-dichlorophenyl) succinimide-induced nephrotoxicity, Toxicology (in press).
Rankin, G.O. , Yang, D.J. , Teets, V.J. , and Brown, P. I., 1986, Deuterium isotope effect in acute N-(3,5-dichlorophenyl) succinimide — induced nephrotoxicity, Life Sci. , 39: 1291.
Rankin, G.O. , Yang, D.J. , Teets, V.J. , Lo, H.H. , and Brown, P. I., 1987b, The effect of probenecid on acute N-(3,5-dichlorophenyl) succinimideinduced nephrotoxicity in the Fischer 344 rat, Toxicology, 44: 181.
Shinohara, Y. , Arai, M. , Hira, K. , Sugihara, S. , Nakanishi, K. , Tsunoda, H. , and Ito, N., 1976, Combination effect of citrinin and other chemicals on rat kidney tumorigenesis, Gann, 67:147.
Sugihara, S. , Shinohara, Y. , Miyata, Y. , Inoue, K. , and Ito, N., 1975, Pathology analysis of chemical nephritis in rats induced by N-(3,5-dichlorophenyl) succinimide. Lab. Invest., 33: 219.
Yang, D.J. , Richmond, C.D. , Teets, V.J. , Brown, P.I. , and Rankin, G.O., 1985, Effect of succinimide ring modification on N-(3,5-dichlorophenyl) — succinimide-induced nephrotoxicity in Sprague-Dawley and Fischer 344 rats, Toxicology, 37: 65.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Rankin, G.O., Yang, D.J., Teets, V.J., Shih, H.C., Brown, P.I. (1989). Role of Biotransformation in Acute N-(3,5-Dichlorophenyl)Succinimide-Induced Nephrotoxicity. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_92
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_92
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive