Abstract
Male rats chronically exposed to inhaled unleaded gasoline (UG) or other petroleum hydrocarbon fuels developed a low but dose-related increase in the incidence of renal adenomas and carcinomas (3,10). Elucidation of the mechanism of this sex and species-specific carcinogenic response to UG is essential for determining the potential human health risk from exposure to UG. Genotoxic assays of UG, including a recently developed in vivo/in vitro unscheduled DNA synthesis assay for the kidney, have been predominately negative (5,13,14,18).
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Short, B.G., Burnett, V.L., Swenberg, J.A. (1989). Pathogenesis of Protein Droplet Nephropathy and Its Relationship to Renal Carcinogenesis in the Male Rat. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_80
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_80
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