Cadmium May Predispose Mice to Immune Complex-Mediated Renal Injury: Another Possible Mechanism for Cadmium-Induced Nephrotoxicity

  • Donna L. Vredevoe
  • Louis Levy
  • David W. Knutson

Abstract

There is strong evidence that chronic ingestion of cadmium results in tubulointerstitial nephritis with a Fanconi-type syndrome in both humans and animals (2,4). There are fewer reports of glomerulonephritis associated with cadmium exposure (1–4) . Those reports that mention glomerular damage usually attribute it to autoantibody production against tissue damaged by cadmium (1,2,4). Our laboratory has accumulated evidence that chronic cadmium ingestion can inhibit clearance of immune complexes by the mononuclear phagocytic system of mice. Such abnormalities may allow the persistence of soluble antigen antibody complexes in the circulation which in turn might lead to greater deposition of the complexes in the glomeruli of the kidney and possibly other sites potentially injurious to organ function.

Keywords

Human Serum Albumin Immune Complex Cadmium Chloride Blood Clearance Cadmium Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    P. Druet, A. Bernard, F. Hirsch, J.J. Weening, P. Gengoux, P. Mahieu and S. Birkeland, Immunologically mediated glomerulonephritis induced by heavy metals, Arch. Toxicol. 50:187 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    H.C. Gonick and H.J. Kramer, Pathogenesis of the Fanconi Syndrome, In: “Renal Tubular Disorders. Pathophysiology, Diagnosis, and Management.” H. C. Gonick and V. M. Buckalew, Jr., eds., Marcel Dekker, New York (1985), pp. 545–607.Google Scholar
  3. 3.
    B.C. Joshi, C. Dwivedi, A. Powell and M. Holscher, Immune complex nephritis in rats induced by long-term oral exposure to cadmium, J. Comp. Pathol. 91:11 (1981).PubMedCrossRefGoogle Scholar
  4. 4.
    T. Kjellstrom, Renal effects, In: “Cadmium and Health: A Toxicological and Epidemiological Appraisal, Vol. II, Effects and Response.” L. Friberg, C.G. Elinder, T. Kjellstrom, and G.F. Nordberg, eds., CRC Press, Boca Raton, Florida (1986), pp. 21–109Google Scholar
  5. 5.
    D.W. Knutson, D.L. Vredevoe, K.R. Aoki, E.F. Hays and L. Levy, Cadmium and the reticuloendothelial system (RES) . A specific defect in blood clearance of soluble aggregates of IgG by the liver in mice given cadmium. Immunology 40:17 (1980).PubMedGoogle Scholar
  6. 6.
    L. Levy, D.L. Vredevoe and G. Cook, In vitro reversibility of cadmiuminduced inhibition of phagocytosis. Environ. Res. 41:361 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    D.L. Vredevoe and L. Levy, Organ-selective impairment of phagocytosis by cadmium, In: “Microenvironments in the Lymphoid System” G.G.B. Klaus, ed., Plenum Publ. Corp. (1985), pp. 749–755.CrossRefGoogle Scholar
  8. 8.
    D.L. Vredevoe, L. Levy, D. Knutson, G. Cook and P. Cohen, Recovery of the murine mononuclear phagocytic system following chronic exposure to cadmium, Environ. Res. 37:373 (1985).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Donna L. Vredevoe
    • 1
  • Louis Levy
    • 1
  • David W. Knutson
    • 1
  1. 1.Schools of Nursing and MedicineUniversity of CaliforniaLos AngelesUSA

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