Abstract
Loop diuretics are assumed to be contraindicated in toxic renal failure, but there are little experimental and clinical data available to support or justify this assumption. Furosemide enhances the nephrotoxic response to both aminoglycoside and cephalosporine antibiotic in mice (James et al., 1975) and in dogs (Adelman et al., 1979), but this was not confirmed in patients (Smith and Lietman, 1983).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Adelman, R.D., Spangler, W.L., Beason, F., Ishizaki, G. and Conzelman, G.M. (1979). Furosemide enhancement of experimental gentamycin nephrotoxicity. Comparison of functional and morphological changes with activities of urinary enzymes. J. Infect. Dis. 140, 342–352.
Davis, J.M., Takabatake, T., Thurau, K. and Haberle, D.A. (1985). The effect of muzolimine on the tubuloglomerular feedback mechanism in the rat kidney. Z. Kardiol. 72, Suppl.2, 161–165.
James, G., Smith, W., Bryant, H. and Balazs, T. (1975). Enhancement of antibiotic nephrotoxicity by furosemide: studies in mice. Toxicol. Appl. Pharmacol. 33, 199.
Smith, C.R. and Lietman, P.S. (1983). Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans. Antimicrob. Agent Chemother. 23, 133–137.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer Science+Business Media New York
About this chapter
Cite this chapter
Siegers, CP., Steffen, B. (1989). Risk Evaluation of Muzolimine and Furosemide in Experimental Models of Nephrotoxicity. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_70
Download citation
DOI: https://doi.org/10.1007/978-1-4757-2040-2_70
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-2042-6
Online ISBN: 978-1-4757-2040-2
eBook Packages: Springer Book Archive