Risk Evaluation of Muzolimine and Furosemide in Experimental Models of Nephrotoxicity
Loop diuretics are assumed to be contraindicated in toxic renal failure, but there are little experimental and clinical data available to support or justify this assumption. Furosemide enhances the nephrotoxic response to both aminoglycoside and cephalosporine antibiotic in mice (James et al., 1975) and in dogs (Adelman et al., 1979), but this was not confirmed in patients (Smith and Lietman, 1983).
KeywordsCarbon Tetrachloride Loop Diuretic Urea Concentration Mercuric Chloride Plasma Creatinine
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