Nephrotoxicity pp 451-456 | Cite as

Risk Evaluation of Muzolimine and Furosemide in Experimental Models of Nephrotoxicity

  • Claus-Peter Siegers
  • Britta Steffen


Loop diuretics are assumed to be contraindicated in toxic renal failure, but there are little experimental and clinical data available to support or justify this assumption. Furosemide enhances the nephrotoxic response to both aminoglycoside and cephalosporine antibiotic in mice (James et al., 1975) and in dogs (Adelman et al., 1979), but this was not confirmed in patients (Smith and Lietman, 1983).


Toxicity Urea Cage Creatinine Gentamicin 
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  1. Adelman, R.D., Spangler, W.L., Beason, F., Ishizaki, G. and Conzelman, G.M. (1979). Furosemide enhancement of experimental gentamycin nephrotoxicity. Comparison of functional and morphological changes with activities of urinary enzymes. J. Infect. Dis. 140, 342–352.PubMedCrossRefGoogle Scholar
  2. Davis, J.M., Takabatake, T., Thurau, K. and Haberle, D.A. (1985). The effect of muzolimine on the tubuloglomerular feedback mechanism in the rat kidney. Z. Kardiol. 72, Suppl.2, 161–165.Google Scholar
  3. James, G., Smith, W., Bryant, H. and Balazs, T. (1975). Enhancement of antibiotic nephrotoxicity by furosemide: studies in mice. Toxicol. Appl. Pharmacol. 33, 199.Google Scholar
  4. Smith, C.R. and Lietman, P.S. (1983). Effect of furosemide on aminoglycoside-induced nephrotoxicity and auditory toxicity in humans. Antimicrob. Agent Chemother. 23, 133–137.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Claus-Peter Siegers
    • 1
  • Britta Steffen
    • 1
  1. 1.Department of ToxicologyMedical University of LubeckLubeckGermany

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