Nephrotoxicity pp 423-432 | Cite as

Cannulation of the Bile Duct Protects Against Para-Aminophenol-Induced Nephrotoxicity in the Fischer 344 Rat

  • K. P. R. Gartland
  • C. T. Eason
  • F. W. Bonner
  • J. K. Nicholson


Para-aminophenol (PAP) produces necrosis of proximal convoluted tubules acutely in the rat after a single injection (1), and has been demonstrated to be a minor metabolite of paracetamol in the Fischer 344 (F344) rat and Fischer-derived isolated perfused kidney (2). Examination of urine from PAP-treated rats by high resolution proton nuclear magnetic resonance (NMR) spectroscopy revealed dose-related elevations in the urinary excretion of glucose, amino acids, and lactic acid (3, 4) while conventional methods showed enzymuria (4).


Toxicity Glutathione Adduct Luminal Thiol 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • K. P. R. Gartland
    • 1
  • C. T. Eason
    • 2
  • F. W. Bonner
    • 2
  • J. K. Nicholson
    • 1
  1. 1.Department of Chemistry, Birkbeck CollegeUniversity of LondonLondonUK
  2. 2.Department of ToxicologySterling-Winthrop Research CentreAlnwick, NorthumberlandUK

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