A Prospective Study of Proteinuria in Cadmium Workers

  • Harry Roels
  • Robert Lauwerys
  • Jean-Pierre Buchet
  • Alfred Bernard
  • Alfons Vos
  • Maurice Oversteyns

Abstract

In man, the kidney is the critical organ following chronic exposure to Cd. An increased urinary excretion of plasma proteins usually represents the earliest biological sign of Cd interference with kidney function. Cadmium can decrease the tubular reabsorption of low molecular weight proteins (< 40, 000 dalton), such as ß2-m and RBP, and it can also enhance the glomerular filtration of high molecular weight proteins (> 40, 000 dalton), such as albumin, representing also an early manifestation of excessive cadmium exposure (Lauwerys et al., 1974 and 1984). The health significance of an increased urinary excretion of specific plasma proteins (e.g. ß2-m, RBP, albumin) without clinical proteinuria which may be found in workers chronically exposed to Cd, remains a matter of controversy (Lauwerys and Bernard, 1986). We have followed up 23 male workers with such renal changes at the time of their removal from exposure to Cd in order to assess whether these early toxic effects of exposure to Cd were predictive of an accelerated decline in renal function.

Keywords

Urinary Excretion High Molecular Weight Protein Accelerate Decline Elevate Serum Creatinine Level Clinical Proteinuria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bernard, A., and Lauwerys, R., 1983, Continuous-flow system for the automation of latex immunoassay, Clin. Chem., 29:1007.PubMedGoogle Scholar
  2. Lauwerys, R., Buchet, J.P., Roels, H., Brouwers, J., and Stanescu, D., 1974, Epidemiologlcal survey of workers exposed to cadmium: effect on lung, kidney and several biological indices, Arch. Environ. Health, 28: 145.PubMedGoogle Scholar
  3. Lauwerys, R., Bernard, A., Roels, H.A., Buchet, J.P., and Viau, C., 1984, Characterization of cadmium proteinuria in man and rat, Environ. Health Perspect., 54: 147.PubMedCrossRefGoogle Scholar
  4. Lauwerys, R.R. , and Bernard, A.M., 1986, Cadmium and the kidney, Brit. J. Ind. Med., 43: 433.Google Scholar
  5. Lindeman, R.D., 1981, Kidney: Kidney and Body Fluids, In: “Handbook of Physiology in Aging”, E.J. Masoro, ed., CRC Press Inc., Boca Raton, Florida.Google Scholar
  6. Roels, H., Djubgang, J., Buchet, J.P., Bernard, A., and Lauwerys, R., 1982, Evolution of cadmium-induced renal dysfunction in workers removed from cadmium exposure, Scand. J. Work Environ. Health, 8: 191.PubMedCrossRefGoogle Scholar
  7. Wibell, L., Evrin, P. E. , and Berggard, I., 1973, Serum ß2-microglobulin in renal disease, Nephron, 10:320.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Harry Roels
    • 1
  • Robert Lauwerys
    • 1
  • Jean-Pierre Buchet
    • 1
  • Alfred Bernard
    • 1
  • Alfons Vos
    • 1
  • Maurice Oversteyns
    • 1
  1. 1.Unite de Toxicologie Industrielle et Medecine du TravailUniversite Catholique de LouvainBrusselsBelgium

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