Abstract
A variety of short-term test have been developed to predict the outcome of carcinogenicity bioassays. Unfortunately, the majority of these do not address the issue of tissue-specificity. Tests that focus on tissuespecific responses such as the in vivo — in vitro unscheduled DNA synthesis (UDS) and S-phase synthesis (SPS) assays (Mirsalis, et al., 1985; Mirsalis, 1987) have been reasonably successful in the prediction of hepatocarcinogenic potential. The most widely used system employs hepatocyte cultures derived from animals treated in vivo (Mirsalis and Butterworth, 1980); however, systems for the kidney (Tyson and Mirsalis, 1985; Loury et al., 1987), pancreas (Steinmetz and Mirsalis, 1984), trachea (Doolittle and Butterworth, 1984), stomach (Furihata et al., 1984), and spermatocytes (Working and Butterworth, 1984) have recently been developed.
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Steinmetz, K., Hamilton, C., Bakke, J., Ramsey, M., Mirsalis, J. (1989). Analysis of Unscheduled Dna Synthesis and S-Phase Synthesis in F344 Rat Kidney After in Vivo Treatment with Mercuric Chloride. In: Bach, P.H., Lock, E.A. (eds) Nephrotoxicity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-2040-2_14
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DOI: https://doi.org/10.1007/978-1-4757-2040-2_14
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