Nephrotoxicity pp 663-671 | Cite as

Endotoxin-Haemoglobin Induced Nephropathy and Haptoglobin Administration

  • Takeshi Ohshiro
  • Kiyoshi Mukai
  • Takesada Mori


Haemolytic renal failure means the renal insufficiency caused by severe haemolysis. This disease had been reported by Yorke (1) and Degowin (2) and recently attracted considerable attention because of the increase of cardiac surgery under extra-corporeal circulation. The pathogenesis is regarded as the nephrotoxic function of free haemoglobin (unbound haemoglobin). In 1975, we demonstrated that the administration of haptoglobin could prevent the morphological abnormalities in rabbits with haemoglobin induced nephropathy and proposed that the haptoglobin therapy could become the effective procedure to prevent haemolytic renal failure (3). Haptoglobin is a component of alpha-2-globulin, related to the metabolism of free haemoglobin by the formation of haptoglobin-haemoglobin complex.


Catheter Filtration Creatinine Pyridine Bilirubin 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Takeshi Ohshiro
    • 1
  • Kiyoshi Mukai
    • 1
  • Takesada Mori
    • 1
  1. 1.Department of Surgery IIOsaka University Medical SchoolFukushima-ku, Osaka 553Japan

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