Nephrotoxicity pp 663-671 | Cite as

Endotoxin-Haemoglobin Induced Nephropathy and Haptoglobin Administration

  • Takeshi Ohshiro
  • Kiyoshi Mukai
  • Takesada Mori

Abstract

Haemolytic renal failure means the renal insufficiency caused by severe haemolysis. This disease had been reported by Yorke (1) and Degowin (2) and recently attracted considerable attention because of the increase of cardiac surgery under extra-corporeal circulation. The pathogenesis is regarded as the nephrotoxic function of free haemoglobin (unbound haemoglobin). In 1975, we demonstrated that the administration of haptoglobin could prevent the morphological abnormalities in rabbits with haemoglobin induced nephropathy and proposed that the haptoglobin therapy could become the effective procedure to prevent haemolytic renal failure (3). Haptoglobin is a component of alpha-2-globulin, related to the metabolism of free haemoglobin by the formation of haptoglobin-haemoglobin complex.

Keywords

Urinary Volume Iron Deposit Urinary Sodium Signifieant Differenee Renal Plasma Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. Yorke, and R. W. Nauss, The mechanism of the production of suppression of urine in blackwater fever, Ann. Trop. Med. Parasitol. 5:287 (1911).Google Scholar
  2. 2.
    E. L. Degowin, H. F. Osterhagen, and M. Andersch, Renal insufficiency from blood transfusion, Arch. Int. Med. 59:432 (1937).CrossRefGoogle Scholar
  3. 3.
    T. Ohshiro, K. Mukai, S. D. Hong, A. Sugitachi, F. Murakami, D. Jinnai, S. Funakoshi, and T. Oomura, The prevention of hemolytic renal failure by haptoglobin-administration (No 1), Saishin Igaku (Japan) 30:656 (1975).Google Scholar
  4. 4.
    T. Ohshiro, and Y. Motoi, The prevention of hemolytic renal failure by haptoglobin-administration (No 2). Saishin Igaku (Japan) 30: 879 (1975).Google Scholar
  5. 5.
    J. Pintera, The protective influence of haptoglobin on hemoglobinuric kidney. I. Biochemical and macroscopic observations, Folia Haematol. 90:80 (1968).Google Scholar
  6. 6.
    J. Pintera, and V. Tomhsek, The protective influence of haptoglobin on hemoglobinuric kidney. II. Microscopic observations and clinical aspect, Inz. Z. Klin. Pharmakol. Ther. Toxikol. 34:371 (1970).Google Scholar
  7. 7.
    T. Ohshiro, K. Mukai, and G. Kosaki, Prevention of hemoglobinuria by administration of haptoglobin, Res. Exp. Med. 177:1 (1980).CrossRefGoogle Scholar
  8. 8.
    N. I. Birrdorf, and H. Loapas, Effects of red cell stroma free hemoglobin solution on renal functions, J. Anpl. Physiol. 29:573 (1970).Google Scholar
  9. 9.
    H. Nakajima, T. Takemura, O. Nakajima, and K. Yamaoka, Studies on heme alpha-methenyl oxygenase. I. The enzymatic conversion of pyridinehemichromogen and hemoglobin-haptoglobin into a possible precursor of biliverdin, J. Biol. Chem. 238:3784 (1963).PubMedGoogle Scholar
  10. 10.
    K. Kino, H. Tsunoo, Y. Higa, M. Takami, H. Hamaguchi, and H. Nakajima, Hemoglobin-haptoglobin receptor in rat liver plasma membrane, J. Biol. Chem. 255:9616 (1980).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Takeshi Ohshiro
    • 1
  • Kiyoshi Mukai
    • 1
  • Takesada Mori
    • 1
  1. 1.Department of Surgery IIOsaka University Medical SchoolFukushima-ku, Osaka 553Japan

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