Nephrotoxicity pp 645-649 | Cite as

Effects of Glycerol-Induced Acute Renal Failure on Renal Phosphorus Handling

  • Christos P. Carvounis
  • Peter Cushley


Previous studies have shown that fractional excretion of phosphorus (FE pi) is increased in rats that developed non-oliguric acute renal failure (ARF) close to 100% indicating that the bulk of filtered phosphorus was excreted in the urine. This finding differs significantly from the finding in rats with mercury chloride-induced oliguric ARF. In the latter, only about 1/4 of the filtered phosphorus reaches the urine, for an FEpi of about 25% (1). A similar finding has been seen also in humans with variable types of ARF (Carvounis, unpublished data).


Phosphorus Glycerol Filtration Mercury Urea 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Popovtzer, M.M. , Massry, S.G. , Villamie, M. , and Kleeman, C.R.: Renal handling of phosphorus in oliguric and non-oliguric mercury-induced acute renal failure in rats. J. Clin. Invest. 50:2347–2354, 1971.PubMedCrossRefGoogle Scholar
  2. 2.
    Wilkes, B.M. and Hollenberg, N.K.: Saline- and glycerol-induced acute renal failure: “protection” occurs after insult. Nephron. 30:352–356, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Hewitt, S.: Method for the microassay of endogenous creatinine in blood and urine of small murid rodents. Lab. Anim. 16:201–203, 1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Scheinman, S.J. and Coulson, R.: Effect of perfusate phosphate concentration on responses to PTH in isolated rat kidney. Am. J. Physiol. 246:F907-F915, 1984.Google Scholar
  5. 5.
    Flamenbaum, W. , Gehr, M. , Gross, M. , Kaufman, J. , and Hamburger, R. In: Acute renal failure associated with myoglobinuria and hemoglobinuria; W.B. Saunders Co. , Phila. , 1983, pp 269–282.Google Scholar
  6. 6.
    Agus, Z.S. , Puschett, J. B. , Senesky, D. , and Goldberg, M.: Mode of action of parathyroid hormone and cyclic adenosine 32 , 52-monophosphate on renal tubular phosphate reabsorption in the dog. J. Clin. Invest. 50: 617–626, 1971.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Christos P. Carvounis
    • 1
  • Peter Cushley
    • 1
  1. 1.Department of Medicine, Section of NephrologyVeterans Administration Medical Center and State University of New YorkSyracuseUSA

Personalised recommendations