Species Differences in Renal Structure and Function — Applications to Nephrotoxicity in Man

  • Bodil Schmidt-Nielsen


A classical example of how physiologists can take advantage of a specific renal adaptation is that of E.K. Marshall Jr. and the aglomerular goose fish (26). Marshall had shown that dog renal tubules accumulate the dye phenol red even when glomerular filtration was stopped by lowering the blood pressure. However, due to the belief held by most physiologists in the theory proposed by Cuhsny (that tubular secretion did not exist), the proofs presented by Marshall were not accepted. Then Marshall found from the literature that some fishes have renal tubules without glomeruli and therefore must form urine entirely by secretion. He came to Mount Desert Island Biological Laboratory in the summer of 1926 to work with the goose fish Lophius piscatorius. The work proved that not only is phenol red secreted by the renal tubules of the goose fish, but also a number of organic acids and bases as well as fluid and electrolytes (27). Wher these results were presented by Marshall his staunch opponent A.N. Richards was overheard saying: “at last Marshall has found one animal that fits his theories” (26).


Permeability Filtration Phenol Urea Epinephrin 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Bodil Schmidt-Nielsen
    • 1
  1. 1.Mount Desert Island Biological LaboratorySalisbury CoveUSA

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