The Pig as an Animal Model for Purine Metabolic Studies
Small laboratory rodents have many disadvantages for the study of purine metabolism in relation to human disease. They normally pass their purine metabolites in much smaller volumes of urine both in relation to bodyweight and filtration rate (1); in addition, the distribution of enzymes of purine catabolism in these species differs from man (2,3). The pig in contrast has a kidney which structurally and functionally resembles human kidneys closely (4,5), and the distribution of xanthine oxidase and guanase is similar to man (2,3). Because of these advantages, and the finding of “guanine gout” in pigs (6), we studied purine metabolism in this animal (7). The pig has proved a much better model.
KeywordsHuman Disease Small Volume Filtration Rate Therapeutic Dose Xanthine Oxidase
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