Purine Metabolism in Man

Biochemistry and Pharmacology of Uric Acid Metabolism

  • Oded Sperling
  • Andre De Vries
  • James B. Wyngaarden

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 41 B)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Gout

    1. Front Matter
      Pages xxiii-xxiii
    2. Etiology of Purine Overproduction in Gout

    3. Effects of Diet, Weight, and Stress on Purine Metabolism

      1. J. A. Dosman, J. C. Crawhall, G. A. Klassen
        Pages 423-427
      2. N. Zöllner, A. Griebsch
        Pages 435-442
    4. Relationship Between Carbohydrate, Lipid, and Purine Metabolism

About this book

Introduction

Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari­ fication.

Keywords

biochemistry DNA enzymes Fructose Glutamin metabolism mutation Nucleotide pharmacology protein Purine Pyrimidine RNA synthesis Xanthin

Editors and affiliations

  • Oded Sperling
    • 1
  • Andre De Vries
    • 1
  • James B. Wyngaarden
    • 2
  1. 1.Division of Metabolic Disease, Rogoff-Wellcome Medical Research InstituteBeilinson HospitalPetah-TikvaIsrael
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4757-1433-3
  • Copyright Information Springer Science+Business Media New York 1974
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-1435-7
  • Online ISBN 978-1-4757-1433-3
  • Series Print ISSN 0065-2598
  • About this book
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