Efficacy of Single Daily Dose Allopurinol in Gouty Hyperuricemia
During the past ten years, since its introduction by Rundles and his colleagues, allopurinol has gained widespread favor in the treatment of gout and other hyperuricemic states (1). Although it is conventional to prescribe allopurinol in multiple divided doses each day, the drug is metabolized in man in such a way as to suggest that a single daily dose may prove equally effective.
KeywordsControl Period Serum Urate Single Daily Dose Gouty Arthritis Serum Urate Level
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- 1.Rundles, R.W., Wyngaarden, J.B., Hitchings, G.H., Elion, G.B., and Silberraan, H.R. Trans. Assoc. Amer, Physicians, 76: 126–140 1963.Google Scholar