Guanidines pp 71-81 | Cite as

Metabolism of L-[Amidino-15N]-Arginine to Guanidino Compounds

  • Shoichiro Shindo
  • Akitane Mori


Since analytical methods for guanidino compounds have recently been developed, it has become possible to get much information about the metabolism of guanidino compounds, especially in uremia1. In the past, stable isotopes were not used for analyses of such compounds as much as radio isotopes were, because the sensitivity was not very high. Recently, however, a new method for nitrogen-15 (15N) analysis was developed, optical emission spectroscopy2, which is several hundred times more sensitive than mass-spectrometry which was used to analyze 15N until now. To examine the metabolism of guanidino compounds in the mouse, the incorporation of a 15N into some guanidino compounds was observed after the administration of L-[amidino-15N]-arginine.


Discharge Tube Arginine Metabolism Arginine Level Guanidino Compound Radio Isotope 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Shoichiro Shindo
    • 1
  • Akitane Mori
    • 1
  1. 1.Inst. for Neurobiol.Okayama Univ. Med. Sch.Japan

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