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Guanidines

Historical, Biological, Biochemical, and Clinical Aspects of the Naturally Occurring Guanidino Compounds

  • Akitane Mori
  • B. D. Cohen
  • A. Lowenthal

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Analytical Method for Guanidino Compounds

    1. Front Matter
      Pages 1-1
    2. Sakae Higashidate, Tetsuya Maekubo, Muneo Saito, Masaaki Senda, Tadao Hoshino
      Pages 3-13
    3. Yiau-Lin Huang, Masaaki Kai, Yosuke Ohkura
      Pages 15-31
    4. Motoo Nakajima, Kazuo Nakamura, Yoshio Shirokane
      Pages 39-46
  3. Metabolism of Guanidino Compound in Normal and Abnormal Organs, and in Metabolic Diseases

    1. Front Matter
      Pages 47-47
    2. Yoko Watanabe, Shoichiro Shindo, Akitane Mori
      Pages 49-58
    3. Yoko Watanabe, Takashi Kadoya, Masayoshi Fukui, Rei Edamatsu, Akitane Mori, Sonoko Seki
      Pages 59-69
    4. Shoichiro Shindo, Akitane Mori
      Pages 71-81
    5. Kazumasa Aoyagi, Shoji Ohba, Mitsuhiro Miyazaki, Sohji Nagase, Satomi Iida, Mitsuharu Narita et al.
      Pages 83-92
    6. Kazumasa Aoyagi, Shoji Ohba, Mitsuhiro Miyazaki, Sohji Nagase, Satomi Iida, Mitsuharu Narita et al.
      Pages 93-103
    7. Hiroaki Muramoto, Yohei Tofuku, Mitsuhiko Kuroda, Ryoyu Takeda
      Pages 105-112
    8. K. C. Chitra, K. S. Swami, K. S. Jagannatha Rao
      Pages 113-118
    9. V. Mohanachari, K. Satyavelu Reddy, K. Indira, K. S. Swami
      Pages 119-124
    10. Harini Patel, Burton D. Cohen
      Pages 135-144
    11. Takeyori Saheki, Mariko Sase, Kyoko Nakano, Yukio Yagi
      Pages 149-158
    12. B. Marescau, I. A. Qureshi, P. De Deyn, J. Letarte, M. Yoshino, A. Lowenthal
      Pages 171-180
    13. Naoki Mizutani, Mitsuo Maehara, Chiemi Hayakawa, Tomoaki Kato, Kazuyoshi Watanabe, Sakae Suzuki
      Pages 181-193
  4. Physiological, Pharmacological and Toxicological Aspects of Guanidino Compound

    1. Front Matter
      Pages 195-195
    2. Masamitsu Fujii, Akio Ando, Hiroshi Mikami, Akira Okada, Enyu Imai, Yukifumi Kokuba et al.
      Pages 197-204
    3. Hiroshi Mikami, Akio Ando, Masamitsu Fujii, Akira Okada, Enyu Imai, Yukifumi Kokuba et al.
      Pages 205-212
    4. R. J. Huxtable, D. Bonhaus, K. Nakagawa, H. E. Laird, H. Pasantes-Morales
      Pages 213-225
    5. Kanji Izumi, Chikara Kishita, Takeshi Koja, Takao Shimizu, Takeo Fukuda, Ryan J. Huxtable
      Pages 227-234
  5. Involvement of Guanidino Compound in Acute and Chronic Renal Failure

    1. Front Matter
      Pages 263-263
    2. Burton D. Cohen
      Pages 265-275
    3. S. Owada, S. Ozawa, M. Inouchi, Y. Kimura, M. Ishida
      Pages 277-285
    4. Yoshinori Kōsogabe, Yōji Ochiai, Rikiya Matsuda, Kyoko Nishitani, Shinya Abe, Yoshitarō Itano et al.
      Pages 287-294
    5. Fumitake Gejyo, Sadao Baba, Yoko Watanabe, Bellamkonda K. Kishore, Yasushi Suzuki, Masaaki Arakawa
      Pages 295-308
    6. Y. Tsubakihara, N. Iida, S. Yuasa, T. Kawashima, I. Nakanishi, M. Tomobuchi et al.
      Pages 309-316
    7. Yōji Ochiai, Rikiya Matsuda, Kyōko Nishitani, Yoshinori Kōsogabe, Shinya Abe, Yoshitarō Itano et al.
      Pages 317-325
    8. Hideo Itabashi, Hisaki Rinno, Hikaru Koide
      Pages 327-334
    9. Mitsuhiro Miyazaki, Kazumasa Aoyagi, Shoji Ohba, Sohji Nagase, Mitsuharu Narita, Shizuo Tojo
      Pages 343-351
    10. Makoto Ishizaki, Hiroshi Kitamura, Hisashi Takahashi, Hisako Asano, Kazuaki Miura, Hajime Okazaki
      Pages 353-363
    11. Y. Tsubakihara, N. Iida, S. Yuasa, T. Kawashima, I. Nakanishi, M. Tomobuchi et al.
      Pages 373-379
  6. Natural Guanidino Compounds: A Review

    1. Front Matter
      Pages 381-381
    2. Y. Robin, B. Marescau
      Pages 383-438
  7. Back Matter
    Pages 439-479

About this book

Introduction

In 1978, we had the first research meeting of guanidine compound analysis in Okayama, Japan. The purpose of the meeting was to standardize the methods of analyzing guanidino compounds, because the analytic methods, even, for example, that of normal plasma, were quite different from laboratory to laboratory at that time. More than ten laboratories joined in this research project. Thereafter, the purpose of the annual meetings was extended to cover general biochemistry of guanidino compounds, and every meeting has served to promote our mutual growth and progress. The last meeting of the Japan Guanidino Compounds Research Association in 1982 brought together more than 80 members, and about 30 papers were presented there. This, the 6th annual meeting, brings the International Symposium on Guani­ dino Compounds here to Tokyo. Recently, many scientists are engaged in the research of guanidine compounds, especially in the field of clinical bio­ chemistry. I am sure that the observation of guanidinosuccinic acid in the urine of uremic patients by Dr. Cohen's research group in 1963 ignited the recent exploration of the role of guanidino compounds in renal diseases. The study of guanidino compounds does, however, have a long history. The first knowledge of guanidine was obtained by Strecker in 1861 (Annalen der Chemie und Pharmacie, 118, 151- 177, 1981).

Keywords

Plasma alcohol biochemistry chemistry growth kidney metabolism paper pharmacology protein protein synthesis quantitative analysis synthesis

Editors and affiliations

  • Akitane Mori
    • 1
  • B. D. Cohen
    • 2
  • A. Lowenthal
    • 3
  1. 1.Inst. for NeurobiologyOkayama University Medical SchoolOkayama 700Japan
  2. 2.The Bronx Lebanon Hospital CenterBronxUSA
  3. 3.Laboratory of Neurochemistry, Born-Bunge FoundationUniversitaire Instelling AntwerpenWilrijkBelgium

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